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Protein

Eukaryotic translation initiation factor 6

Gene

eif6

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif6
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-868348. eif6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Eukaryotic translation initiation factor 6PRO_0000402097Add
BLAST

PTM databases

iPTMnetiQ6GR45.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GR45.
SMRiQ6GR45. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG001300.
KOiK03264.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GR45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRASFENN NEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSETIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL MVPNNTTDQE LQHMRNSLPD SVRIQRVEER
110 120 130 140 150
LSALGNVIAC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TIAEQVLVGS
160 170 180 190 200
YCAFSNQGGL LHPKTSIEDQ DELSSLLQVP LVTGTVNRGS EVIAAGMVVN
210 220 230 240
DWCAFCGLDT TSTELSVIES VFKLSDAHPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,654
Last modified:July 19, 2004 - v1
Checksum:i22527055B5E0258A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381D → G in AAQ88443 (PubMed:16425228).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY383654 mRNA. Translation: AAQ88443.1.
BC071088 mRNA. Translation: AAH71088.1.
RefSeqiNP_001083080.1. NM_001089611.1.
UniGeneiXl.5851.

Genome annotation databases

GeneIDi398731.
KEGGixla:398731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY383654 mRNA. Translation: AAQ88443.1.
BC071088 mRNA. Translation: AAH71088.1.
RefSeqiNP_001083080.1. NM_001089611.1.
UniGeneiXl.5851.

3D structure databases

ProteinModelPortaliQ6GR45.
SMRiQ6GR45. Positions 1-224.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6GR45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398731.
KEGGixla:398731.

Organism-specific databases

CTDi3692.
XenbaseiXB-GENE-868348. eif6.

Phylogenomic databases

HOVERGENiHBG001300.
KOiK03264.

Family and domain databases

HAMAPiMF_00032. eIF_6.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of p27BBP/eIF6 is highly modulated during Xenopus laevis embryogenesis."
    Vaccaro M.C., Cuccaro M., De Marco N., Campanella C.
    Mol. Reprod. Dev. 73:482-490(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiIF6_XENLA
AccessioniPrimary (citable) accession number: Q6GR45
Secondary accession number(s): Q6TXJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: July 19, 2004
Last modified: January 20, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.