Q6GR25 (PPTC7_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein phosphatase PTC7 homolog
EC=3.1.3.16

Gene names

Name:

pptc7

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium or manganese Potential.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Protein phosphatase PTC7 homolog		PRO_0000328748
Regions
	Domain	40 – 290	251	PP2C-like
Sites
	Metal binding	71	1	Manganese 1 By similarity
	Metal binding	71	1	Manganese 2 By similarity
	Metal binding	72	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	216	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GR25 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: E4AEF12609A04725	FASTA	297	32,427
	10 20 30 40 50 60 MFSVLSCGRL VARAVFGGLS QTDSRDYSLV TASCGFGKDA RKGILKKGMC YGDDACFIAR 70 80 90 100 110 120 HRTADVLGVA DGVGGWRDYG VDPSQFSETL MRTCERLVKE GRFVPTNPVG ILTSSYRELL 130 140 150 160 170 180 QNKVPLLGSS TACLVVLDRT SHRLHTANLG DSGFLVVRAG EVVHRSDEQQ HYFNTPFQLS 190 200 210 220 230 240 IAPPEAEGAV LSDSPDAADS NSFDVQLGDI ILTATDGLFD NMPDYMILQE LKKLKNTNYE 250 260 270 280 290 SIQQTARSIA EQAHDLAYDP NYMSPFAQFA CDYGLNVRGG KPDDITVLLS IVAEYTD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC071109 mRNA. Translation: AAH71109.1.
RefSeq	NP_001085343.1. NM_001091874.1.
UniGene	Xl.53093.
3D structure databases
ProteinModelPortal	Q6GR25.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	443769.
KEGG	xla:443769.
Organism-specific databases
CTD	160760.
Xenbase	XB-GENE-1012927. pptc7.
Phylogenomic databases
HOVERGEN	HBG060636.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. [Graphical view]
Pfam	PF07228. SpoIIE. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPTC7_XENLA

Accession

Primary (citable) accession number: Q6GR25

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	July 19, 2004
Last modified:	March 6, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program