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Protein

Macrophage erythroblast attacher

Gene

maea

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a possible role in erythroblast and macrophages maturation. May associate with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Erythrocyte maturation

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage erythroblast attacher
Gene namesi
Name:maea
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-483836. maea.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Macrophage erythroblast attacherPRO_0000284943Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 15333LisHPROSITE-ProRule annotationAdd
BLAST
Domaini159 – 21658CTLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG053270.
KOiK18624.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GR10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQESAAQL SMALKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV
60 70 80 90 100
VAELEKTLSS CSAVDSVVSL LDGVVEKLSV LKRKAMESIQ AEDESAKLCK
110 120 130 140 150
RRIEHLKEHS SDQTAAINMW KKKRMDRMMV EHLLRCGYYN TAVKLARQSE
160 170 180 190 200
IEDLVNIEMF LTAKEVEESL ERQETMTCLA WCHDNKSRLR KMKSCLEFSL
210 220 230 240 250
RIQEFIELIR QNKRLDAVRH ARKHFSQAEG SQLDEVRQVM GMLAFPSDTH
260 270 280 290 300
ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNNSVFTITL QAGLSAIKTP
310 320 330 340 350
QCYKEDGTSK NPDCPVCSKS LNKLAQPLPL AHCANSRLVC KISGDVMNEN
360 370 380 390
NPPMMLPNGY VYGYNSLLSI RQDDKVVCPR TKEVFNFSQA EKVYIM
Length:396
Mass (Da):45,481
Last modified:May 1, 2007 - v2
Checksum:i496FC738ED10D94D
GO

Sequence cautioni

The sequence AAH71124.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071124 mRNA. Translation: AAH71124.1. Different initiation.
RefSeqiNP_001085357.2. NM_001091888.1.
UniGeneiXl.22576.

Genome annotation databases

GeneIDi443783.
KEGGixla:443783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC071124 mRNA. Translation: AAH71124.1. Different initiation.
RefSeqiNP_001085357.2. NM_001091888.1.
UniGeneiXl.22576.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443783.
KEGGixla:443783.

Organism-specific databases

CTDi10296.
XenbaseiXB-GENE-483836. maea.

Phylogenomic databases

HOVERGENiHBG053270.
KOiK18624.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiMAEA_XENLA
AccessioniPrimary (citable) accession number: Q6GR10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 1, 2015
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.