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Protein

Erythroid differentiation-related factor 1

Gene

Edrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythroid differentiation-related factor 1
Gene namesi
Name:Edrf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919831. Edrf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12391239Erythroid differentiation-related factor 1PRO_0000244261Add
BLAST

Proteomic databases

EPDiQ6GQV7.
MaxQBiQ6GQV7.
PaxDbiQ6GQV7.
PRIDEiQ6GQV7.

PTM databases

iPTMnetiQ6GQV7.
PhosphoSiteiQ6GQV7.

Expressioni

Gene expression databases

BgeeiQ6GQV7.
CleanExiMM_2700050L05RIK.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059166.

Structurei

3D structure databases

ProteinModelPortaliQ6GQV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati693 – 72634TPR 1Add
BLAST
Repeati914 – 95340TPR 2Add
BLAST

Sequence similaritiesi

Contains 2 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiENOG410IF2A. Eukaryota.
ENOG410XSWW. LUCA.
HOGENOMiHOG000006629.
HOVERGENiHBG081471.
InParanoidiQ6GQV7.
OMAiFAEFQMT.
PhylomeDBiQ6GQV7.

Sequencei

Sequence statusi: Complete.

Q6GQV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDPKEAGAE ASPSGAAARG GLSLLSQADS EEPSAQGSAL FLGGNEVKSR
60 70 80 90 100
AVVKYSSAPP RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK
110 120 130 140 150
SKPFSSFGMA YDFIDSVGND VDVVSDSENI KKLLKIPYSK SHVSMAVHRI
160 170 180 190 200
GRTLLLDELD IQELFMRSSQ TGDWTWLKEF YQRLIDQKWQ RKKKSKEHWY
210 220 230 240 250
QKAILSKFLY YSINGDGAAQ PVPSPAEQEE SSSSQQTHES EGAAWPAPFE
260 270 280 290 300
MPSSVSEDPS ASSQGREPLE PSCIVGHVAS APKEQNLTTL FNDGENSQGL
310 320 330 340 350
KNDFVRNILW TFEDIHMLVG SNMPIFGGGR YPAVSLRLRD NNKPINVLTG
360 370 380 390 400
IDYWLDNLIC NVPELVMCFH VNGIVQKYEM IKTEEIPNLE NSNFSTKVIK
410 420 430 440 450
DIAQNILSFL KSNCTKEGHT YWLFKASGSD IVKLYDLTTL CEETEDKYQN
460 470 480 490 500
PFTMPVAILL YKVACNMMMK KNQNKKHYGT IRTLLLNCVK LLDKSRHPQI
510 520 530 540 550
IASANYMLSE LFQLDEPKKE ESSDSPLNEN SDESYSEEEE EMADSDENGS
560 570 580 590 600
YSTSSDPADD NKAVAIIKSV GELSVPEKYK SIHQIRPSCA FPVCHDTEER
610 620 630 640 650
CRLVLSYVLE GLKSVDSSIK KESDLPAADP STPIPLKYED ESTRGGPEGL
660 670 680 690 700
EKQMALFLDK MGSIQKGSCS GQSGMTPGSW QHKMKLQLIL KSSKAYYILS
710 720 730 740 750
DAAMSLQKYG RALRYIKLAL QSHDTYCCLC TNMLSEVLLF LSQYLTLCGD
760 770 780 790 800
IQLMLAQNAN NRAAHLEEFN YQTKEDQEIL HSLHRESSCQ GFAWATDLST
810 820 830 840 850
DLESQLSVSC KCYEAANEIL QFSDLKSQNP EHYVQVLKRM GNIRNEIGVF
860 870 880 890 900
YMNQAAALQG ERVVSKSVSA AEQQLWKKSF SCFEKGIHNF ESIDDATNAA
910 920 930 940 950
LLLCNTGRLM RVCAQAHCGA EDEFKREFSP EEGLYYSKAV DYYLKALRSL
960 970 980 990 1000
GTRDMHPIVW DSVNWELSTT YFTMATLQQD YAPLSRKAQE QIEKEVSEAM
1010 1020 1030 1040 1050
MKSLKHCDVD SATARQPLCQ YRAATIHHRL ASMYHSCLRN QVGDEHLRKQ
1060 1070 1080 1090 1100
HRVLADLHYS KAAKLFQLLK DAPCELLRVQ LERVAFAEFQ MSSQNSNVGK
1110 1120 1130 1140 1150
LKTLSGALDI MVRTEHAFQL IRKELVEECD QPKNDEATPA ADSSPNLNRE
1160 1170 1180 1190 1200
EVIKLLSIFE SRLSFLLLQS IKLMSSSKRK MSSNAEEDIV LQTNKQIYSQ
1210 1220 1230
LLRATANRNS TLLERIEVVI CLLEQLASGS SRSSGSAVP
Length:1,239
Mass (Da):138,834
Last modified:July 19, 2004 - v1
Checksum:i53C896457CF75797
GO

Sequence cautioni

The sequence AAH24916.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH46235.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024916 mRNA. Translation: AAH24916.1. Different initiation.
BC046235 mRNA. Translation: AAH46235.1. Different initiation.
BC072596 mRNA. Translation: AAH72596.1.
RefSeqiNP_835216.3. NM_178115.4.
UniGeneiMm.174044.

Genome annotation databases

GeneIDi214764.
KEGGimmu:214764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC024916 mRNA. Translation: AAH24916.1. Different initiation.
BC046235 mRNA. Translation: AAH46235.1. Different initiation.
BC072596 mRNA. Translation: AAH72596.1.
RefSeqiNP_835216.3. NM_178115.4.
UniGeneiMm.174044.

3D structure databases

ProteinModelPortaliQ6GQV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059166.

PTM databases

iPTMnetiQ6GQV7.
PhosphoSiteiQ6GQV7.

Proteomic databases

EPDiQ6GQV7.
MaxQBiQ6GQV7.
PaxDbiQ6GQV7.
PRIDEiQ6GQV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi214764.
KEGGimmu:214764.

Organism-specific databases

CTDi26098.
MGIiMGI:1919831. Edrf1.

Phylogenomic databases

eggNOGiENOG410IF2A. Eukaryota.
ENOG410XSWW. LUCA.
HOGENOMiHOG000006629.
HOVERGENiHBG081471.
InParanoidiQ6GQV7.
OMAiFAEFQMT.
PhylomeDBiQ6GQV7.

Miscellaneous databases

NextBioi374458.
PROiQ6GQV7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6GQV7.
CleanExiMM_2700050L05RIK.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Fetal brain and Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiEDRF1_MOUSE
AccessioniPrimary (citable) accession number: Q6GQV7
Secondary accession number(s): Q80ZY3, Q8R3P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 19, 2004
Last modified: March 16, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.