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Protein

Kelch-like protein 23

Gene

Klhl23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 23
Gene namesi
Name:Klhl23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2683536. Klhl23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002421581 – 558Kelch-like protein 23Add BLAST558

Proteomic databases

PaxDbiQ6GQU2.
PRIDEiQ6GQU2.

PTM databases

PhosphoSitePlusiQ6GQU2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042155.
CleanExiMM_KLHL23.
GenevisibleiQ6GQU2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050219.

Structurei

3D structure databases

ProteinModelPortaliQ6GQU2.
SMRiQ6GQU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 104BTBPROSITE-ProRule annotationAdd BLAST69
Domaini139 – 240BACKAdd BLAST102
Repeati274 – 320Kelch 1Add BLAST47
Repeati321 – 369Kelch 2Add BLAST49
Repeati370 – 416Kelch 3Add BLAST47
Repeati418 – 466Kelch 4Add BLAST49
Repeati467 – 508Kelch 5Add BLAST42
Repeati510 – 557Kelch 6Add BLAST48

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000231807.
HOVERGENiHBG096077.
InParanoidiQ6GQU2.
KOiK10460.
OMAiKKACEQF.
OrthoDBiEOG091G03GU.
PhylomeDBiQ6GQU2.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GQU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKGQEDYI FHFKDSSHPV DFLDAFRTFY MDGLFTDITL QCPSGIIFHC
60 70 80 90 100
HRAVLAACSN YFKAMFTADM KEKFKSKIKL SGIHHDILEG LVNYAYTSQI
110 120 130 140 150
EITKRNVQSL LEAADLLQFL SVKKACEQFL VRHLDIDNCI GMHSFAEFHV
160 170 180 190 200
CSELEKESRR ILCSRFKEVW QQEEFLEISL EKFLFILSRK NLSVWKEEAI
210 220 230 240 250
LEPVIKWTAH DVENRIECIY NLLSYINIDI DPVYLKTALG LQRSCLLTEN
260 270 280 290 300
KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
310 320 330 340 350
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIDALDTVW IYNSEGDEWT
360 370 380 390 400
EGLPMLNARY YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWLPIA
410 420 430 440 450
NMIKGVGNAT ACVLHEVIYV IGGHCGYRGS CTYDKVQSYN SDINEWSLIT
460 470 480 490 500
ASPHPEYGLC SVPFENKLYL VGGQTTITEC YDPEQNEWRE TAPMMERRME
510 520 530 540 550
CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV GNLPSAMRSH

GCVCVYNV
Length:558
Mass (Da):63,840
Last modified:July 19, 2004 - v1
Checksum:iE338A317110DAAEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti359R → G in BAC33355 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048518 mRNA. Translation: BAC33355.1.
AL845261 Genomic DNA. Translation: CAM16376.1.
BC072626 mRNA. Translation: AAH72626.1.
CCDSiCCDS16100.1.
RefSeqiNP_808452.2. NM_177784.4.
XP_006499740.1. XM_006499677.1.
XP_006499741.1. XM_006499678.3.
UniGeneiMm.138073.

Genome annotation databases

EnsembliENSMUST00000053087; ENSMUSP00000050219; ENSMUSG00000042155.
GeneIDi277396.
KEGGimmu:277396.
UCSCiuc008jys.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048518 mRNA. Translation: BAC33355.1.
AL845261 Genomic DNA. Translation: CAM16376.1.
BC072626 mRNA. Translation: AAH72626.1.
CCDSiCCDS16100.1.
RefSeqiNP_808452.2. NM_177784.4.
XP_006499740.1. XM_006499677.1.
XP_006499741.1. XM_006499678.3.
UniGeneiMm.138073.

3D structure databases

ProteinModelPortaliQ6GQU2.
SMRiQ6GQU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050219.

PTM databases

PhosphoSitePlusiQ6GQU2.

Proteomic databases

PaxDbiQ6GQU2.
PRIDEiQ6GQU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053087; ENSMUSP00000050219; ENSMUSG00000042155.
GeneIDi277396.
KEGGimmu:277396.
UCSCiuc008jys.2. mouse.

Organism-specific databases

CTDi151230.
MGIiMGI:2683536. Klhl23.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00850000132244.
HOGENOMiHOG000231807.
HOVERGENiHBG096077.
InParanoidiQ6GQU2.
KOiK10460.
OMAiKKACEQF.
OrthoDBiEOG091G03GU.
PhylomeDBiQ6GQU2.
TreeFamiTF329218.

Miscellaneous databases

PROiQ6GQU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042155.
CleanExiMM_KLHL23.
GenevisibleiQ6GQU2. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH23_MOUSE
AccessioniPrimary (citable) accession number: Q6GQU2
Secondary accession number(s): A2AR06, Q8C840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.