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Q6GQT9

- NOMO1_MOUSE

UniProt

Q6GQT9 - NOMO1_MOUSE

Protein

Nodal modulator 1

Gene

Nomo1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    May antagonize Nodal signaling.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nodal modulator 1Imported
    Gene namesi
    Name:Nomo1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2385850. Nomo1.

    Subcellular locationi

    Membrane Sequence Analysis; Single-pass type I membrane protein Sequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 12141191Nodal modulator 1Sequence AnalysisPRO_0000396822Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1196 – 11961Phosphoserine1 Publication
    Modified residuei1197 – 11971Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ6GQT9.
    PaxDbiQ6GQT9.
    PRIDEiQ6GQT9.

    PTM databases

    PhosphoSiteiQ6GQT9.

    Expressioni

    Gene expression databases

    BgeeiQ6GQT9.
    GenevestigatoriQ6GQT9.

    Interactioni

    Protein-protein interaction databases

    BioGridi229243. 1 interaction.
    IntActiQ6GQT9. 2 interactions.
    MINTiMINT-4110969.
    STRINGi10090.ENSMUSP00000033121.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQT9.
    SMRiQ6GQT9. Positions 66-93, 123-179, 263-289, 322-390, 420-462, 507-555, 823-850, 869-944, 954-1042.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 11501127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1168 – 121447CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1151 – 116717HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili692 – 72029Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG237157.
    GeneTreeiENSGT00390000000089.
    HOVERGENiHBG071511.
    InParanoidiQ8R1I7.
    OMAiEFSYWAR.
    OrthoDBiEOG77M8NC.
    PhylomeDBiQ6GQT9.
    TreeFamiTF313696.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    2.60.40.1120. 2 hits.
    InterProiIPR013784. Carb-bd-like_fold.
    IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SUPFAMiSSF49452. SSF49452. 3 hits.
    SSF49464. SSF49464. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6GQT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAGRCAAAL LLLLLSGAGR AIGSEDIVVG CGGFVKSDVE INYSLIEIKL     50
    YTKHGTLKYQ TDCAPNNGYF MIPLYDKGDF ILKIEPPLGW SFEPTNVELR 100
    VDGVSDICTK GGDINFLFTG FSVNGKVLSK GQPLGPAGVQ VSLRSTGADS 150
    KIQSTVTQPG GKFAFFKVLP GDYEILATHP TWALKEASTT VRVTNSNANA 200
    AGPLIVAGYN VSGSVRSDGE PMKGVKFLLF SSLVNKEDVL GCNVSPVSGF 250
    QPPDESLVYL CYAVSKEDGS FSFYSLPSGG YTVVPFYRGE RITFDVAPSR 300
    LDFTVEHDSL RIEPVFHVMG FSVTGRVLNG PDGEGVPEAV VTLNNQIKVK 350
    TKADGSFRLE NITTGTYTIH AQKEHLYFEM VTIKIAPNTP QLADLIATGF 400
    SICGQIAIVR SPDTIKQMSK YRVVLSSQDK DKALLTVDSD AHGSFCFKAK 450
    PGAYKVQVVV PEAETRAGLM LKPQVFPLTV TNRPVMDVAF VQFLASVSGK 500
    VSCLDTCGDL LVTLQSLSRQ GEKRSLQLSG KVNSMTFTFD KVLPGRYKIS 550
    IMHEDWCWRN KSLEVEVLED DVSAVEFRQT GYMLRCALSH AITLEFHQDG 600
    NGPENVGIYN LSRGVNRFCL SKPGVYKVTP RSCHRFEQAF YTYDTSSPSI 650
    LTLTAIRHHV LGTIITDKMM DVTVTIKSSI DSEPALVLGP LKSAQELRRE 700
    QQLAEIETRR QEREKNGKEE GEEGRARPPG QEMVDELQGP FSYDFSYWAR 750
    SGEKITVTPS SKELLFYPPS MEATVSGESC PGKLIEIHGK AGLFLEGQIH 800
    PELEGVEIVI SEKGASSPLI TVFTDDKGAY SVGPLHSDLE YTVNSQKEGY 850
    VLTAVEGTVG DFKAYALAGV SFEIKAEDDQ PLPGVLLSLS GGVFRSNLLT 900
    QDNGILTFSN LSPGQYYFKP MMKEFRFEPS SQMIEVQEGQ NLRITITGFR 950
    TAYSCYGTVS SLNGEPEQGV AVEAVGQKDC SIYGEDTVTD EEGKFRLRGL 1000
    LPGCMYHVQL KAEGNDHIER ALPHHRVIEV GNNDVDDVNI IVFRQINQFD 1050
    LSGNVITSSE YLSTLWVKLY KSESLDNPIQ TVSLGQSLFF HFPPLLRDGE 1100
    NYVVLLDTTL PRSQYDYVLP QVSFTAVGYH KHITLVFSPT RKLPEQDIAQ 1150
    GSYIALPLTL LLLLAGYNHD KLIPLLLQLT SRLQGVRALG QAASDSSGPE 1200
    DMKRQTKKQK TRRT 1214
    Length:1,214
    Mass (Da):133,420
    Last modified:July 19, 2004 - v1
    Checksum:i0F71587617C444A7
    GO

    Sequence cautioni

    The sequence AAH24503.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH33923.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC38713.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61C → G in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti62 – 632DC → GW in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti75 – 751Y → V in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti95 – 973TNV → PHG in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti101 – 1011V → G in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti109 – 1091T → A in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti113 – 1131D → G in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti477 – 4771P → T in BAC38508. (PubMed:16141072)Curated
    Sequence conflicti875 – 8784KAED → GRVG in AAH24503. (PubMed:15489334)Curated
    Sequence conflicti1029 – 10291E → G in BAC31513. (PubMed:16141072)Curated
    Sequence conflicti1176 – 11761L → V in BAC31513. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043279 mRNA. Translation: BAC31513.1.
    AK082495 mRNA. Translation: BAC38508.1.
    AK082963 mRNA. Translation: BAC38713.1. Different initiation.
    AK166764 mRNA. Translation: BAE39002.1.
    BC024503 mRNA. Translation: AAH24503.1. Different initiation.
    BC033923 mRNA. Translation: AAH33923.1. Different initiation.
    BC072630 mRNA. Translation: AAH72630.1.
    CCDSiCCDS21273.1.
    RefSeqiNP_694697.3. NM_153057.4.
    UniGeneiMm.274811.

    Genome annotation databases

    EnsembliENSMUST00000033121; ENSMUSP00000033121; ENSMUSG00000030835.
    GeneIDi211548.
    KEGGimmu:211548.
    UCSCiuc009gyb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043279 mRNA. Translation: BAC31513.1 .
    AK082495 mRNA. Translation: BAC38508.1 .
    AK082963 mRNA. Translation: BAC38713.1 . Different initiation.
    AK166764 mRNA. Translation: BAE39002.1 .
    BC024503 mRNA. Translation: AAH24503.1 . Different initiation.
    BC033923 mRNA. Translation: AAH33923.1 . Different initiation.
    BC072630 mRNA. Translation: AAH72630.1 .
    CCDSi CCDS21273.1.
    RefSeqi NP_694697.3. NM_153057.4.
    UniGenei Mm.274811.

    3D structure databases

    ProteinModelPortali Q6GQT9.
    SMRi Q6GQT9. Positions 66-93, 123-179, 263-289, 322-390, 420-462, 507-555, 823-850, 869-944, 954-1042.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229243. 1 interaction.
    IntActi Q6GQT9. 2 interactions.
    MINTi MINT-4110969.
    STRINGi 10090.ENSMUSP00000033121.

    PTM databases

    PhosphoSitei Q6GQT9.

    Proteomic databases

    MaxQBi Q6GQT9.
    PaxDbi Q6GQT9.
    PRIDEi Q6GQT9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033121 ; ENSMUSP00000033121 ; ENSMUSG00000030835 .
    GeneIDi 211548.
    KEGGi mmu:211548.
    UCSCi uc009gyb.2. mouse.

    Organism-specific databases

    CTDi 23420.
    MGIi MGI:2385850. Nomo1.

    Phylogenomic databases

    eggNOGi NOG237157.
    GeneTreei ENSGT00390000000089.
    HOVERGENi HBG071511.
    InParanoidi Q8R1I7.
    OMAi EFSYWAR.
    OrthoDBi EOG77M8NC.
    PhylomeDBi Q6GQT9.
    TreeFami TF313696.

    Miscellaneous databases

    NextBioi 373278.
    PROi Q6GQT9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6GQT9.
    Genevestigatori Q6GQT9.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    2.60.40.1120. 2 hits.
    InterProi IPR013784. Carb-bd-like_fold.
    IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SUPFAMi SSF49452. SSF49452. 3 hits.
    SSF49464. SSF49464. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: BlastocystImported, CerebellumImported and Embryonic spinal cordImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported and FVB/NImported.
      Tissue: BrainImported, ColonImported and LiverImported.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1196 AND SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver1 Publication.

    Entry informationi

    Entry nameiNOMO1_MOUSE
    AccessioniPrimary (citable) accession number: Q6GQT9
    Secondary accession number(s): Q3TKZ1
    , Q8BJM1, Q8BJM8, Q8BLS9, Q8K074, Q8R1I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3