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Protein

Nodal modulator 1

Gene

Nomo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May antagonize Nodal signaling.By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 1Imported
Gene namesi
Name:Nomo1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2385850. Nomo1.

Subcellular locationi

  1. Membrane Sequence Analysis; Single-pass type I membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 11501127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1151 – 116717HelicalSequence AnalysisAdd
BLAST
Topological domaini1168 – 121447CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 12141191Nodal modulator 1Sequence AnalysisPRO_0000396822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence Analysis
Modified residuei1196 – 11961Phosphoserine1 Publication
Modified residuei1197 – 11971Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6GQT9.
PaxDbiQ6GQT9.
PRIDEiQ6GQT9.

PTM databases

PhosphoSiteiQ6GQT9.

Expressioni

Gene expression databases

BgeeiQ6GQT9.
GenevestigatoriQ6GQT9.

Interactioni

Protein-protein interaction databases

BioGridi229243. 2 interactions.
IntActiQ6GQT9. 2 interactions.
MINTiMINT-4110969.
STRINGi10090.ENSMUSP00000033121.

Structurei

3D structure databases

ProteinModelPortaliQ6GQT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili692 – 72029Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237157.
GeneTreeiENSGT00390000000089.
HOVERGENiHBG071511.
InParanoidiQ6GQT9.
OMAiEFSYWAR.
OrthoDBiEOG77M8NC.
PhylomeDBiQ6GQT9.
TreeFamiTF313696.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1120. 2 hits.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAGRCAAAL LLLLLSGAGR AIGSEDIVVG CGGFVKSDVE INYSLIEIKL
60 70 80 90 100
YTKHGTLKYQ TDCAPNNGYF MIPLYDKGDF ILKIEPPLGW SFEPTNVELR
110 120 130 140 150
VDGVSDICTK GGDINFLFTG FSVNGKVLSK GQPLGPAGVQ VSLRSTGADS
160 170 180 190 200
KIQSTVTQPG GKFAFFKVLP GDYEILATHP TWALKEASTT VRVTNSNANA
210 220 230 240 250
AGPLIVAGYN VSGSVRSDGE PMKGVKFLLF SSLVNKEDVL GCNVSPVSGF
260 270 280 290 300
QPPDESLVYL CYAVSKEDGS FSFYSLPSGG YTVVPFYRGE RITFDVAPSR
310 320 330 340 350
LDFTVEHDSL RIEPVFHVMG FSVTGRVLNG PDGEGVPEAV VTLNNQIKVK
360 370 380 390 400
TKADGSFRLE NITTGTYTIH AQKEHLYFEM VTIKIAPNTP QLADLIATGF
410 420 430 440 450
SICGQIAIVR SPDTIKQMSK YRVVLSSQDK DKALLTVDSD AHGSFCFKAK
460 470 480 490 500
PGAYKVQVVV PEAETRAGLM LKPQVFPLTV TNRPVMDVAF VQFLASVSGK
510 520 530 540 550
VSCLDTCGDL LVTLQSLSRQ GEKRSLQLSG KVNSMTFTFD KVLPGRYKIS
560 570 580 590 600
IMHEDWCWRN KSLEVEVLED DVSAVEFRQT GYMLRCALSH AITLEFHQDG
610 620 630 640 650
NGPENVGIYN LSRGVNRFCL SKPGVYKVTP RSCHRFEQAF YTYDTSSPSI
660 670 680 690 700
LTLTAIRHHV LGTIITDKMM DVTVTIKSSI DSEPALVLGP LKSAQELRRE
710 720 730 740 750
QQLAEIETRR QEREKNGKEE GEEGRARPPG QEMVDELQGP FSYDFSYWAR
760 770 780 790 800
SGEKITVTPS SKELLFYPPS MEATVSGESC PGKLIEIHGK AGLFLEGQIH
810 820 830 840 850
PELEGVEIVI SEKGASSPLI TVFTDDKGAY SVGPLHSDLE YTVNSQKEGY
860 870 880 890 900
VLTAVEGTVG DFKAYALAGV SFEIKAEDDQ PLPGVLLSLS GGVFRSNLLT
910 920 930 940 950
QDNGILTFSN LSPGQYYFKP MMKEFRFEPS SQMIEVQEGQ NLRITITGFR
960 970 980 990 1000
TAYSCYGTVS SLNGEPEQGV AVEAVGQKDC SIYGEDTVTD EEGKFRLRGL
1010 1020 1030 1040 1050
LPGCMYHVQL KAEGNDHIER ALPHHRVIEV GNNDVDDVNI IVFRQINQFD
1060 1070 1080 1090 1100
LSGNVITSSE YLSTLWVKLY KSESLDNPIQ TVSLGQSLFF HFPPLLRDGE
1110 1120 1130 1140 1150
NYVVLLDTTL PRSQYDYVLP QVSFTAVGYH KHITLVFSPT RKLPEQDIAQ
1160 1170 1180 1190 1200
GSYIALPLTL LLLLAGYNHD KLIPLLLQLT SRLQGVRALG QAASDSSGPE
1210
DMKRQTKKQK TRRT
Length:1,214
Mass (Da):133,420
Last modified:July 19, 2004 - v1
Checksum:i0F71587617C444A7
GO

Sequence cautioni

The sequence AAH24503.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH33923.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC38713.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61C → G in BAC38508 (PubMed:16141072).Curated
Sequence conflicti62 – 632DC → GW in BAC38508 (PubMed:16141072).Curated
Sequence conflicti75 – 751Y → V in BAC38508 (PubMed:16141072).Curated
Sequence conflicti95 – 973TNV → PHG in BAC38508 (PubMed:16141072).Curated
Sequence conflicti101 – 1011V → G in BAC38508 (PubMed:16141072).Curated
Sequence conflicti109 – 1091T → A in BAC38508 (PubMed:16141072).Curated
Sequence conflicti113 – 1131D → G in BAC38508 (PubMed:16141072).Curated
Sequence conflicti477 – 4771P → T in BAC38508 (PubMed:16141072).Curated
Sequence conflicti875 – 8784KAED → GRVG in AAH24503 (PubMed:15489334).Curated
Sequence conflicti1029 – 10291E → G in BAC31513 (PubMed:16141072).Curated
Sequence conflicti1176 – 11761L → V in BAC31513 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043279 mRNA. Translation: BAC31513.1.
AK082495 mRNA. Translation: BAC38508.1.
AK082963 mRNA. Translation: BAC38713.1. Different initiation.
AK166764 mRNA. Translation: BAE39002.1.
BC024503 mRNA. Translation: AAH24503.1. Different initiation.
BC033923 mRNA. Translation: AAH33923.1. Different initiation.
BC072630 mRNA. Translation: AAH72630.1.
CCDSiCCDS21273.1.
RefSeqiNP_694697.3. NM_153057.4.
UniGeneiMm.274811.

Genome annotation databases

EnsembliENSMUST00000033121; ENSMUSP00000033121; ENSMUSG00000030835.
GeneIDi211548.
KEGGimmu:211548.
UCSCiuc009gyb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043279 mRNA. Translation: BAC31513.1.
AK082495 mRNA. Translation: BAC38508.1.
AK082963 mRNA. Translation: BAC38713.1. Different initiation.
AK166764 mRNA. Translation: BAE39002.1.
BC024503 mRNA. Translation: AAH24503.1. Different initiation.
BC033923 mRNA. Translation: AAH33923.1. Different initiation.
BC072630 mRNA. Translation: AAH72630.1.
CCDSiCCDS21273.1.
RefSeqiNP_694697.3. NM_153057.4.
UniGeneiMm.274811.

3D structure databases

ProteinModelPortaliQ6GQT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229243. 2 interactions.
IntActiQ6GQT9. 2 interactions.
MINTiMINT-4110969.
STRINGi10090.ENSMUSP00000033121.

PTM databases

PhosphoSiteiQ6GQT9.

Proteomic databases

MaxQBiQ6GQT9.
PaxDbiQ6GQT9.
PRIDEiQ6GQT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033121; ENSMUSP00000033121; ENSMUSG00000030835.
GeneIDi211548.
KEGGimmu:211548.
UCSCiuc009gyb.2. mouse.

Organism-specific databases

CTDi23420.
MGIiMGI:2385850. Nomo1.

Phylogenomic databases

eggNOGiNOG237157.
GeneTreeiENSGT00390000000089.
HOVERGENiHBG071511.
InParanoidiQ6GQT9.
OMAiEFSYWAR.
OrthoDBiEOG77M8NC.
PhylomeDBiQ6GQT9.
TreeFamiTF313696.

Miscellaneous databases

NextBioi373278.
PROiQ6GQT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6GQT9.
GenevestigatoriQ6GQT9.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1120. 2 hits.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: BlastocystImported, CerebellumImported and Embryonic spinal cordImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported and FVB/NImported.
    Tissue: BrainImported, ColonImported and LiverImported.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1196 AND SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNOMO1_MOUSE
AccessioniPrimary (citable) accession number: Q6GQT9
Secondary accession number(s): Q3TKZ1
, Q8BJM1, Q8BJM8, Q8BLS9, Q8K074, Q8R1I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 19, 2004
Last modified: March 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.