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Q6GQT9

- NOMO1_MOUSE

UniProt

Q6GQT9 - NOMO1_MOUSE

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Protein
Nodal modulator 1
Gene
Nomo1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May antagonize Nodal signaling By similarity.By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 1
Gene namesi
Name:Nomo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2385850. Nomo1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 11501127Extracellular Reviewed prediction
Add
BLAST
Transmembranei1151 – 116717Helical; Reviewed prediction
Add
BLAST
Topological domaini1168 – 121447Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 12141191Nodal modulator 1
PRO_0000396822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi610 – 6101N-linked (GlcNAc...) Reviewed prediction
Modified residuei1196 – 11961Phosphoserine1 Publication
Modified residuei1197 – 11971Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6GQT9.
PaxDbiQ6GQT9.
PRIDEiQ6GQT9.

PTM databases

PhosphoSiteiQ6GQT9.

Expressioni

Gene expression databases

BgeeiQ6GQT9.
GenevestigatoriQ6GQT9.

Interactioni

Protein-protein interaction databases

BioGridi229243. 1 interaction.
IntActiQ6GQT9. 2 interactions.
MINTiMINT-4110969.
STRINGi10090.ENSMUSP00000033121.

Structurei

3D structure databases

ProteinModelPortaliQ6GQT9.
SMRiQ6GQT9. Positions 66-93, 123-179, 263-289, 322-390, 420-462, 507-555, 823-850, 869-944, 954-1042.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili692 – 72029 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG237157.
GeneTreeiENSGT00390000000089.
HOVERGENiHBG071511.
InParanoidiQ8R1I7.
OMAiEFSYWAR.
OrthoDBiEOG77M8NC.
PhylomeDBiQ6GQT9.
TreeFamiTF313696.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1120. 2 hits.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQT9-1 [UniParc]FASTAAdd to Basket

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MRAGRCAAAL LLLLLSGAGR AIGSEDIVVG CGGFVKSDVE INYSLIEIKL     50
YTKHGTLKYQ TDCAPNNGYF MIPLYDKGDF ILKIEPPLGW SFEPTNVELR 100
VDGVSDICTK GGDINFLFTG FSVNGKVLSK GQPLGPAGVQ VSLRSTGADS 150
KIQSTVTQPG GKFAFFKVLP GDYEILATHP TWALKEASTT VRVTNSNANA 200
AGPLIVAGYN VSGSVRSDGE PMKGVKFLLF SSLVNKEDVL GCNVSPVSGF 250
QPPDESLVYL CYAVSKEDGS FSFYSLPSGG YTVVPFYRGE RITFDVAPSR 300
LDFTVEHDSL RIEPVFHVMG FSVTGRVLNG PDGEGVPEAV VTLNNQIKVK 350
TKADGSFRLE NITTGTYTIH AQKEHLYFEM VTIKIAPNTP QLADLIATGF 400
SICGQIAIVR SPDTIKQMSK YRVVLSSQDK DKALLTVDSD AHGSFCFKAK 450
PGAYKVQVVV PEAETRAGLM LKPQVFPLTV TNRPVMDVAF VQFLASVSGK 500
VSCLDTCGDL LVTLQSLSRQ GEKRSLQLSG KVNSMTFTFD KVLPGRYKIS 550
IMHEDWCWRN KSLEVEVLED DVSAVEFRQT GYMLRCALSH AITLEFHQDG 600
NGPENVGIYN LSRGVNRFCL SKPGVYKVTP RSCHRFEQAF YTYDTSSPSI 650
LTLTAIRHHV LGTIITDKMM DVTVTIKSSI DSEPALVLGP LKSAQELRRE 700
QQLAEIETRR QEREKNGKEE GEEGRARPPG QEMVDELQGP FSYDFSYWAR 750
SGEKITVTPS SKELLFYPPS MEATVSGESC PGKLIEIHGK AGLFLEGQIH 800
PELEGVEIVI SEKGASSPLI TVFTDDKGAY SVGPLHSDLE YTVNSQKEGY 850
VLTAVEGTVG DFKAYALAGV SFEIKAEDDQ PLPGVLLSLS GGVFRSNLLT 900
QDNGILTFSN LSPGQYYFKP MMKEFRFEPS SQMIEVQEGQ NLRITITGFR 950
TAYSCYGTVS SLNGEPEQGV AVEAVGQKDC SIYGEDTVTD EEGKFRLRGL 1000
LPGCMYHVQL KAEGNDHIER ALPHHRVIEV GNNDVDDVNI IVFRQINQFD 1050
LSGNVITSSE YLSTLWVKLY KSESLDNPIQ TVSLGQSLFF HFPPLLRDGE 1100
NYVVLLDTTL PRSQYDYVLP QVSFTAVGYH KHITLVFSPT RKLPEQDIAQ 1150
GSYIALPLTL LLLLAGYNHD KLIPLLLQLT SRLQGVRALG QAASDSSGPE 1200
DMKRQTKKQK TRRT 1214
Length:1,214
Mass (Da):133,420
Last modified:July 19, 2004 - v1
Checksum:i0F71587617C444A7
GO

Sequence cautioni

The sequence AAH24503.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH33923.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC38713.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61C → G in BAC38508. 1 Publication
Sequence conflicti62 – 632DC → GW in BAC38508. 1 Publication
Sequence conflicti75 – 751Y → V in BAC38508. 1 Publication
Sequence conflicti95 – 973TNV → PHG in BAC38508. 1 Publication
Sequence conflicti101 – 1011V → G in BAC38508. 1 Publication
Sequence conflicti109 – 1091T → A in BAC38508. 1 Publication
Sequence conflicti113 – 1131D → G in BAC38508. 1 Publication
Sequence conflicti477 – 4771P → T in BAC38508. 1 Publication
Sequence conflicti875 – 8784KAED → GRVG in AAH24503. 1 Publication
Sequence conflicti1029 – 10291E → G in BAC31513. 1 Publication
Sequence conflicti1176 – 11761L → V in BAC31513. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043279 mRNA. Translation: BAC31513.1.
AK082495 mRNA. Translation: BAC38508.1.
AK082963 mRNA. Translation: BAC38713.1. Different initiation.
AK166764 mRNA. Translation: BAE39002.1.
BC024503 mRNA. Translation: AAH24503.1. Different initiation.
BC033923 mRNA. Translation: AAH33923.1. Different initiation.
BC072630 mRNA. Translation: AAH72630.1.
CCDSiCCDS21273.1.
RefSeqiNP_694697.3. NM_153057.4.
UniGeneiMm.274811.

Genome annotation databases

EnsembliENSMUST00000033121; ENSMUSP00000033121; ENSMUSG00000030835.
GeneIDi211548.
KEGGimmu:211548.
UCSCiuc009gyb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043279 mRNA. Translation: BAC31513.1 .
AK082495 mRNA. Translation: BAC38508.1 .
AK082963 mRNA. Translation: BAC38713.1 . Different initiation.
AK166764 mRNA. Translation: BAE39002.1 .
BC024503 mRNA. Translation: AAH24503.1 . Different initiation.
BC033923 mRNA. Translation: AAH33923.1 . Different initiation.
BC072630 mRNA. Translation: AAH72630.1 .
CCDSi CCDS21273.1.
RefSeqi NP_694697.3. NM_153057.4.
UniGenei Mm.274811.

3D structure databases

ProteinModelPortali Q6GQT9.
SMRi Q6GQT9. Positions 66-93, 123-179, 263-289, 322-390, 420-462, 507-555, 823-850, 869-944, 954-1042.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229243. 1 interaction.
IntActi Q6GQT9. 2 interactions.
MINTi MINT-4110969.
STRINGi 10090.ENSMUSP00000033121.

PTM databases

PhosphoSitei Q6GQT9.

Proteomic databases

MaxQBi Q6GQT9.
PaxDbi Q6GQT9.
PRIDEi Q6GQT9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033121 ; ENSMUSP00000033121 ; ENSMUSG00000030835 .
GeneIDi 211548.
KEGGi mmu:211548.
UCSCi uc009gyb.2. mouse.

Organism-specific databases

CTDi 23420.
MGIi MGI:2385850. Nomo1.

Phylogenomic databases

eggNOGi NOG237157.
GeneTreei ENSGT00390000000089.
HOVERGENi HBG071511.
InParanoidi Q8R1I7.
OMAi EFSYWAR.
OrthoDBi EOG77M8NC.
PhylomeDBi Q6GQT9.
TreeFami TF313696.

Miscellaneous databases

NextBioi 373278.
PROi Q6GQT9.
SOURCEi Search...

Gene expression databases

Bgeei Q6GQT9.
Genevestigatori Q6GQT9.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1120. 2 hits.
InterProi IPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view ]
SUPFAMi SSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Blastocyst, Cerebellum and Embryonic spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain, Colon and Liver.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1196 AND SER-1197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNOMO1_MOUSE
AccessioniPrimary (citable) accession number: Q6GQT9
Secondary accession number(s): Q3TKZ1
, Q8BJM1, Q8BJM8, Q8BLS9, Q8K074, Q8R1I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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