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Q6GQT0

- CC14A_MOUSE

UniProt

Q6GQT0 - CC14A_MOUSE

Protein

Dual specificity protein phosphatase CDC14A

Gene

Cdc14a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei278 – 2781Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_215601. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase CDC14A (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    CDC14 cell division cycle 14 homolog A
    Gene namesi
    Name:Cdc14a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2442676. Cdc14a.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell
    4. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 603603Dual specificity protein phosphatase CDC14APRO_0000094877Add
    BLAST

    Proteomic databases

    PRIDEiQ6GQT0.

    PTM databases

    PhosphoSiteiQ6GQT0.

    Expressioni

    Gene expression databases

    BgeeiQ6GQT0.
    GenevestigatoriQ6GQT0.

    Interactioni

    Subunit structurei

    Interacts with KIF20A. Interaction is required to localize CDC14 to the midzone of the mitotic spindle By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000087950.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQT0.
    SMRiQ6GQT0. Positions 15-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 162156AAdd
    BLAST
    Regioni163 – 17614LinkerAdd
    BLAST
    Regioni177 – 343167BAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi539 – 54911Poly-SerAdd
    BLAST
    Compositional biasi580 – 5856Poly-Ser

    Domaini

    Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00390000010254.
    HOGENOMiHOG000198341.
    HOVERGENiHBG050818.
    InParanoidiQ6GQT0.
    KOiK06639.
    OMAiNNQYSRS.
    OrthoDBiEOG776SPM.
    PhylomeDBiQ6GQT0.
    TreeFamiTF101053.

    Family and domain databases

    Gene3Di3.90.190.10. 2 hits.
    InterProiIPR029260. DSPn.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR026068. Dual_Pase_CDC14A.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR23339:SF62. PTHR23339:SF62. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF14671. DSPn. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6GQT0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAESGELIG ACEFMKDRLY FATLRNRPKS TINIHYFSID EELVYENFYA    50
    DFGPLNLAMV YRYCCKLNKK LKSYSLSRKK IVHYTSFDQR KRANAAFLIG 100
    AYAVIYLKKT PEEAYRALLS GSNPPYLPFR DASFGNCTYN LTVLDCLQGI 150
    RKGLQHGFFD FETFDAEEYE HYERVENGDF NWIVPGKFLA FSGPHPKSKI 200
    ENGYPLHAPE AYFPYFKKNN VTTIVRLNKK IYEAKRFTDA GFEHYDLFFI 250
    DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT 300
    HAEIIAWIRI CRPGSIIGPQ QHFLKEKQAS LWVQGDIFRS KLKNRPSSEG 350
    SITKIISTLD DMSIGANLSK LQSTERIGEN NFEDEDMEIK NNVTQGDKLR 400
    ALKSQRHPRS SPSCAFRSDD MKGHQRAMAQ TFRLSSSPQP TMSTMKTSKV 450
    CLSPSVTAKK ISRGSLSSGA NIRSFSINSR LASSLGNLNA GTEEPETKKT 500
    TSLTKAAFIA SPFTSFLNGS TQTPGRNYPE LNNNQYTRSS NSNSSSSSSG 550
    LGGNLNSSPV PQSAKPEEHT TILRPSFPGS LSSSSVRFLS RSIPSLQSEY 600
    VHY 603
    Length:603
    Mass (Da):67,634
    Last modified:December 21, 2004 - v2
    Checksum:i496676322A54C078
    GO
    Isoform 2 (identifier: Q6GQT0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         104-152: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:554
    Mass (Da):62,115
    Checksum:iD63622E867C09338
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei104 – 15249Missing in isoform 2. 1 PublicationVSP_012324Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072644 mRNA. Translation: AAH72644.1.
    AK036556 mRNA. Translation: BAC29476.1.
    CCDSiCCDS38611.1. [Q6GQT0-1]
    CCDS51058.1. [Q6GQT0-2]
    RefSeqiNP_001074287.1. NM_001080818.2. [Q6GQT0-1]
    NP_001167024.1. NM_001173553.1. [Q6GQT0-2]
    UniGeneiMm.17647.

    Genome annotation databases

    EnsembliENSMUST00000090464; ENSMUSP00000087950; ENSMUSG00000033502. [Q6GQT0-1]
    ENSMUST00000106491; ENSMUSP00000102100; ENSMUSG00000033502. [Q6GQT0-2]
    GeneIDi229776.
    KEGGimmu:229776.
    UCSCiuc008rca.1. mouse. [Q6GQT0-1]
    uc012cwq.1. mouse. [Q6GQT0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072644 mRNA. Translation: AAH72644.1 .
    AK036556 mRNA. Translation: BAC29476.1 .
    CCDSi CCDS38611.1. [Q6GQT0-1 ]
    CCDS51058.1. [Q6GQT0-2 ]
    RefSeqi NP_001074287.1. NM_001080818.2. [Q6GQT0-1 ]
    NP_001167024.1. NM_001173553.1. [Q6GQT0-2 ]
    UniGenei Mm.17647.

    3D structure databases

    ProteinModelPortali Q6GQT0.
    SMRi Q6GQT0. Positions 15-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000087950.

    PTM databases

    PhosphoSitei Q6GQT0.

    Proteomic databases

    PRIDEi Q6GQT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090464 ; ENSMUSP00000087950 ; ENSMUSG00000033502 . [Q6GQT0-1 ]
    ENSMUST00000106491 ; ENSMUSP00000102100 ; ENSMUSG00000033502 . [Q6GQT0-2 ]
    GeneIDi 229776.
    KEGGi mmu:229776.
    UCSCi uc008rca.1. mouse. [Q6GQT0-1 ]
    uc012cwq.1. mouse. [Q6GQT0-2 ]

    Organism-specific databases

    CTDi 8556.
    MGIi MGI:2442676. Cdc14a.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00390000010254.
    HOGENOMi HOG000198341.
    HOVERGENi HBG050818.
    InParanoidi Q6GQT0.
    KOi K06639.
    OMAi NNQYSRS.
    OrthoDBi EOG776SPM.
    PhylomeDBi Q6GQT0.
    TreeFami TF101053.

    Enzyme and pathway databases

    Reactomei REACT_215601. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.

    Miscellaneous databases

    NextBioi 379667.
    PROi Q6GQT0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6GQT0.
    Genevestigatori Q6GQT0.

    Family and domain databases

    Gene3Di 3.90.190.10. 2 hits.
    InterProi IPR029260. DSPn.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR026068. Dual_Pase_CDC14A.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR23339:SF62. PTHR23339:SF62. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF14671. DSPn. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 72-603 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Bone.

    Entry informationi

    Entry nameiCC14A_MOUSE
    AccessioniPrimary (citable) accession number: Q6GQT0
    Secondary accession number(s): Q8BZ66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3