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Protein

Calcium-binding mitochondrial carrier protein SCaMC-3

Gene

Slc25a23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 331PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi89 – 1002PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • adenine nucleotide transport Source: MGI
  • calcium ion transmembrane import into mitochondrion Source: UniProtKB
  • cellular response to calcium ion Source: MGI
  • mitochondrial calcium ion transport Source: UniProtKB
  • regulation of cellular respiration Source: MGI
  • regulation of oxidative phosphorylation Source: MGI
  • regulation of sequestering of calcium ion Source: MGI
  • urea homeostasis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-3
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 3
Solute carrier family 25 member 23
Gene namesi
Name:Slc25a23
Synonyms:Scamc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914222. Slc25a23.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 187Mitochondrial intermembraneSequence analysisAdd BLAST187
Transmembranei188 – 205Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini206 – 242Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei243 – 262Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini263 – 285Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei286 – 299Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini300 – 335Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei336 – 355Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini356 – 378Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei379 – 396Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini397 – 435Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei436 – 455Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini456 – 467Mitochondrial intermembraneSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176101 – 467Calcium-binding mitochondrial carrier protein SCaMC-3Add BLAST467

Proteomic databases

MaxQBiQ6GQS1.
PaxDbiQ6GQS1.
PeptideAtlasiQ6GQS1.
PRIDEiQ6GQS1.

PTM databases

PhosphoSitePlusiQ6GQS1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046329.
ExpressionAtlasiQ6GQS1. baseline and differential.
GenevisibleiQ6GQS1. MM.

Interactioni

Subunit structurei

Interacts with MCU. Interacts with MICU1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040198.

Structurei

3D structure databases

ProteinModelPortaliQ6GQS1.
SMRiQ6GQS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini76 – 111EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini112 – 147EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Repeati182 – 268Solcar 1Add BLAST87
Repeati276 – 361Solcar 2Add BLAST86
Repeati373 – 461Solcar 3Add BLAST89

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ6GQS1.
KOiK14684.
OMAiESDINHD.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ6GQS1.
TreeFamiTF313492.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GQS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGSSDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGRGDPDRAQ
60 70 80 90 100
QGVSSDWDAD PDGGLSLEEF TRYLQEREQR LLLMFHSLDR NQDGHIDVSE
110 120 130 140 150
IQQSFRALGI SISLEQAEKI LHSMDRDGTM TIDWQEWRDH FLLHSLENVE
160 170 180 190 200
DVLYFWKHST VLDIGECLTV PDEFSQEEKL TGMWWKQLVA GAVAGAVSRT
210 220 230 240 250
GTAPLDRLKV FMQVHASKSN RLNILGGLRN MIQEGGVLSL WRGNGINVLK
260 270 280 290 300
IAPESAIKFM AYEQIKRAIR GQQETLHVQE RFVAGSLAGA TAQTIIYPME
310 320 330 340 350
VLKTRLTLRR TGQYKGLLDC AKRILEREGP RAFYRGYLPN VLGIIPYAGI
360 370 380 390 400
DLAVYETLKN RWLQQYSHES ANPGILVLLG CGTISSTCGQ IASYPLALVR
410 420 430 440 450
TRMQAQASIE GGPQVSMVGL LRHILSQEGV WGLYRGIAPN FMKVIPAVSI
460
SYVVYENMKQ ALGVTSR
Length:467
Mass (Da):52,497
Last modified:July 19, 2004 - v1
Checksum:i6C17CB6C03CDD8B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072660 mRNA. Translation: AAH72660.1.
CCDSiCCDS28923.1.
RefSeqiNP_080153.2. NM_025877.4.
UniGeneiMm.23720.
Mm.415988.

Genome annotation databases

EnsembliENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329.
GeneIDi66972.
KEGGimmu:66972.
UCSCiuc008ddu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072660 mRNA. Translation: AAH72660.1.
CCDSiCCDS28923.1.
RefSeqiNP_080153.2. NM_025877.4.
UniGeneiMm.23720.
Mm.415988.

3D structure databases

ProteinModelPortaliQ6GQS1.
SMRiQ6GQS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040198.

PTM databases

PhosphoSitePlusiQ6GQS1.

Proteomic databases

MaxQBiQ6GQS1.
PaxDbiQ6GQS1.
PeptideAtlasiQ6GQS1.
PRIDEiQ6GQS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329.
GeneIDi66972.
KEGGimmu:66972.
UCSCiuc008ddu.2. mouse.

Organism-specific databases

CTDi79085.
MGIiMGI:1914222. Slc25a23.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ6GQS1.
KOiK14684.
OMAiESDINHD.
OrthoDBiEOG091G0C8S.
PhylomeDBiQ6GQS1.
TreeFamiTF313492.

Miscellaneous databases

PROiQ6GQS1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046329.
ExpressionAtlasiQ6GQS1. baseline and differential.
GenevisibleiQ6GQS1. MM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCMC3_MOUSE
AccessioniPrimary (citable) accession number: Q6GQS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.