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Protein

Calcium-binding mitochondrial carrier protein SCaMC-3

Gene

Slc25a23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 331PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi89 – 1002PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • adenine nucleotide transport Source: MGI
  • calcium import into the mitochondrion Source: UniProtKB
  • cellular response to calcium ion Source: MGI
  • mitochondrial calcium ion transmembrane transport Source: UniProtKB
  • mitochondrial transport Source: GO_Central
  • regulation of cellular respiration Source: MGI
  • regulation of oxidative phosphorylation Source: MGI
  • regulation of sequestering of calcium ion Source: MGI
  • urea homeostasis Source: MGI

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-3
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 3
Solute carrier family 25 member 23
Gene namesi
Name:Slc25a23
Synonyms:Scamc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914222 Slc25a23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 187Mitochondrial intermembraneSequence analysisAdd BLAST187
Transmembranei188 – 205Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini206 – 242Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei243 – 262Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini263 – 285Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei286 – 299Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini300 – 335Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei336 – 355Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini356 – 378Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei379 – 396Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini397 – 435Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei436 – 455Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini456 – 467Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176101 – 467Calcium-binding mitochondrial carrier protein SCaMC-3Add BLAST467

Proteomic databases

MaxQBiQ6GQS1
PaxDbiQ6GQS1
PeptideAtlasiQ6GQS1
PRIDEiQ6GQS1

PTM databases

PhosphoSitePlusiQ6GQS1

Expressioni

Gene expression databases

BgeeiENSMUSG00000046329
ExpressionAtlasiQ6GQS1 baseline and differential
GenevisibleiQ6GQS1 MM

Interactioni

Subunit structurei

Interacts with MCU. Interacts with MICU1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040198

Structurei

3D structure databases

ProteinModelPortaliQ6GQS1
SMRiQ6GQS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 44EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini76 – 111EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini112 – 147EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Repeati182 – 268Solcar 1Add BLAST87
Repeati276 – 361Solcar 2Add BLAST86
Repeati373 – 461Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00880000137904
HOGENOMiHOG000165728
HOVERGENiHBG108464
InParanoidiQ6GQS1
KOiK14684
OMAiEFTRYLQ
OrthoDBiEOG091G0C8S
PhylomeDBiQ6GQS1
TreeFamiTF313492

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6GQS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGSSDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGRGDPDRAQ
60 70 80 90 100
QGVSSDWDAD PDGGLSLEEF TRYLQEREQR LLLMFHSLDR NQDGHIDVSE
110 120 130 140 150
IQQSFRALGI SISLEQAEKI LHSMDRDGTM TIDWQEWRDH FLLHSLENVE
160 170 180 190 200
DVLYFWKHST VLDIGECLTV PDEFSQEEKL TGMWWKQLVA GAVAGAVSRT
210 220 230 240 250
GTAPLDRLKV FMQVHASKSN RLNILGGLRN MIQEGGVLSL WRGNGINVLK
260 270 280 290 300
IAPESAIKFM AYEQIKRAIR GQQETLHVQE RFVAGSLAGA TAQTIIYPME
310 320 330 340 350
VLKTRLTLRR TGQYKGLLDC AKRILEREGP RAFYRGYLPN VLGIIPYAGI
360 370 380 390 400
DLAVYETLKN RWLQQYSHES ANPGILVLLG CGTISSTCGQ IASYPLALVR
410 420 430 440 450
TRMQAQASIE GGPQVSMVGL LRHILSQEGV WGLYRGIAPN FMKVIPAVSI
460
SYVVYENMKQ ALGVTSR
Length:467
Mass (Da):52,497
Last modified:July 19, 2004 - v1
Checksum:i6C17CB6C03CDD8B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072660 mRNA Translation: AAH72660.1
CCDSiCCDS28923.1
RefSeqiNP_080153.2, NM_025877.4
UniGeneiMm.23720
Mm.415988

Genome annotation databases

EnsembliENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329
GeneIDi66972
KEGGimmu:66972
UCSCiuc008ddu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSCMC3_MOUSE
AccessioniPrimary (citable) accession number: Q6GQS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health