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Protein

Calcium-binding mitochondrial carrier protein SCaMC-3

Gene

Slc25a23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi22 – 33121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi89 – 100122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • adenine nucleotide transport Source: MGI
  • cellular response to calcium ion Source: MGI
  • regulation of cellular respiration Source: MGI
  • regulation of oxidative phosphorylation Source: MGI
  • regulation of sequestering of calcium ion Source: MGI
  • translation Source: GO_Central
  • transmembrane transport Source: InterPro
  • urea homeostasis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-3
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 3
Solute carrier family 25 member 23
Gene namesi
Name:Slc25a23
Synonyms:Scamc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914222. Slc25a23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 187187Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei188 – 20518Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini206 – 24237Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei243 – 26220Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini263 – 28523Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei286 – 29914Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini300 – 33536Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei336 – 35520Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini356 – 37823Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei379 – 39618Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini397 – 43539Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei436 – 45520Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini456 – 46712Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Calcium-binding mitochondrial carrier protein SCaMC-3PRO_0000317610Add
BLAST

Proteomic databases

EPDiQ6GQS1.
MaxQBiQ6GQS1.
PaxDbiQ6GQS1.
PeptideAtlasiQ6GQS1.
PRIDEiQ6GQS1.

PTM databases

PhosphoSiteiQ6GQS1.

Expressioni

Gene expression databases

BgeeiQ6GQS1.
ExpressionAtlasiQ6GQS1. baseline and differential.
GenevisibleiQ6GQS1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040198.

Structurei

3D structure databases

ProteinModelPortaliQ6GQS1.
SMRiQ6GQS1. Positions 13-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 4436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini76 – 11136EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini112 – 14736EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Repeati182 – 26887Solcar 1Add
BLAST
Repeati276 – 36186Solcar 2Add
BLAST
Repeati373 – 46189Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation
Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ6GQS1.
KOiK14684.
OMAiIMPAIRD.
OrthoDBiEOG7V7661.
PhylomeDBiQ6GQS1.
TreeFamiTF313492.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GQS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGSSDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGRGDPDRAQ
60 70 80 90 100
QGVSSDWDAD PDGGLSLEEF TRYLQEREQR LLLMFHSLDR NQDGHIDVSE
110 120 130 140 150
IQQSFRALGI SISLEQAEKI LHSMDRDGTM TIDWQEWRDH FLLHSLENVE
160 170 180 190 200
DVLYFWKHST VLDIGECLTV PDEFSQEEKL TGMWWKQLVA GAVAGAVSRT
210 220 230 240 250
GTAPLDRLKV FMQVHASKSN RLNILGGLRN MIQEGGVLSL WRGNGINVLK
260 270 280 290 300
IAPESAIKFM AYEQIKRAIR GQQETLHVQE RFVAGSLAGA TAQTIIYPME
310 320 330 340 350
VLKTRLTLRR TGQYKGLLDC AKRILEREGP RAFYRGYLPN VLGIIPYAGI
360 370 380 390 400
DLAVYETLKN RWLQQYSHES ANPGILVLLG CGTISSTCGQ IASYPLALVR
410 420 430 440 450
TRMQAQASIE GGPQVSMVGL LRHILSQEGV WGLYRGIAPN FMKVIPAVSI
460
SYVVYENMKQ ALGVTSR
Length:467
Mass (Da):52,497
Last modified:July 19, 2004 - v1
Checksum:i6C17CB6C03CDD8B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072660 mRNA. Translation: AAH72660.1.
CCDSiCCDS28923.1.
RefSeqiNP_080153.2. NM_025877.4.
UniGeneiMm.23720.
Mm.415988.

Genome annotation databases

EnsembliENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329.
GeneIDi66972.
KEGGimmu:66972.
UCSCiuc008ddu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072660 mRNA. Translation: AAH72660.1.
CCDSiCCDS28923.1.
RefSeqiNP_080153.2. NM_025877.4.
UniGeneiMm.23720.
Mm.415988.

3D structure databases

ProteinModelPortaliQ6GQS1.
SMRiQ6GQS1. Positions 13-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040198.

PTM databases

PhosphoSiteiQ6GQS1.

Proteomic databases

EPDiQ6GQS1.
MaxQBiQ6GQS1.
PaxDbiQ6GQS1.
PeptideAtlasiQ6GQS1.
PRIDEiQ6GQS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329.
GeneIDi66972.
KEGGimmu:66972.
UCSCiuc008ddu.2. mouse.

Organism-specific databases

CTDi79085.
MGIiMGI:1914222. Slc25a23.

Phylogenomic databases

eggNOGiKOG0036. Eukaryota.
ENOG410XQ4P. LUCA.
GeneTreeiENSGT00760000119245.
HOGENOMiHOG000165728.
HOVERGENiHBG108464.
InParanoidiQ6GQS1.
KOiK14684.
OMAiIMPAIRD.
OrthoDBiEOG7V7661.
PhylomeDBiQ6GQS1.
TreeFamiTF313492.

Miscellaneous databases

PROiQ6GQS1.
SOURCEiSearch...

Gene expression databases

BgeeiQ6GQS1.
ExpressionAtlasiQ6GQS1. baseline and differential.
GenevisibleiQ6GQS1. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.50.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
PF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiSCMC3_MOUSE
AccessioniPrimary (citable) accession number: Q6GQS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.