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Q6GQP4

- RAB31_RAT

UniProt

Q6GQP4 - RAB31_RAT

Protein

Ras-related protein Rab-31

Gene

Rab31

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium By similarity. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi60 – 645GTPBy similarity
    Nucleotide bindingi118 – 1214GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to insulin stimulus Source: UniProtKB
    2. Golgi to plasma membrane protein transport Source: UniProtKB
    3. Golgi vesicle transport Source: RGD
    4. phagosome maturation Source: UniProtKB
    5. receptor internalization Source: UniProtKB
    6. regulated secretory pathway Source: UniProtKB
    7. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-31
    Alternative name(s):
    GTP-binding protein Rab0
    Gene namesi
    Name:Rab31
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi628598. Rab31.

    Subcellular locationi

    Golgi apparatustrans-Golgi network By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Early endosome By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Rapidly recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. phagocytic vesicle Source: UniProtKB
    3. phagocytic vesicle membrane Source: UniProtKB-SubCell
    4. trans-Golgi network membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194Ras-related protein Rab-31PRO_0000121234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351PhosphoserineBy similarity
    Lipidationi193 – 1931S-geranylgeranyl cysteineBy similarity
    Lipidationi194 – 1941S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Phosphoprotein, Prenylation

    Proteomic databases

    PRIDEiQ6GQP4.

    Expressioni

    Tissue specificityi

    Detected in brain astrocytes, spleen and intestine (at protein level).2 Publications

    Gene expression databases

    GenevestigatoriQ6GQP4.

    Interactioni

    Subunit structurei

    Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with NGFR. Interacts with EGFR By similarity. Interacts with OCRL.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ6GQP4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQP4.
    SMRiQ6GQP4. Positions 3-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 429Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00640000091139.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    KOiK07891.
    OMAiIKLGKQT.
    OrthoDBiEOG77DJ7M.
    PhylomeDBiQ6GQP4.
    TreeFamiTF331262.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GQP4-1 [UniParc]FASTAAdd to Basket

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    MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG    50
    NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFHTLKKWV 100
    KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GALVVETSAK 150
    NAINIEELFQ GISRQIPPLD PHENGNSGGI KLGNQSLQAG RRCC 194
    Length:194
    Mass (Da):21,368
    Last modified:April 26, 2005 - v2
    Checksum:iD48C9C68E4476205
    GO

    Sequence cautioni

    The sequence AAH72698.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061H → Y in AAF67746. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254800 mRNA. Translation: AAF67746.1.
    BC072698 mRNA. Translation: AAH72698.1. Different initiation.
    RefSeqiNP_659562.2. NM_145094.2.
    UniGeneiRn.28921.

    Genome annotation databases

    EnsembliENSRNOT00000067974; ENSRNOP00000063486; ENSRNOG00000042189.
    GeneIDi246324.
    KEGGirno:246324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254800 mRNA. Translation: AAF67746.1 .
    BC072698 mRNA. Translation: AAH72698.1 . Different initiation.
    RefSeqi NP_659562.2. NM_145094.2.
    UniGenei Rn.28921.

    3D structure databases

    ProteinModelPortali Q6GQP4.
    SMRi Q6GQP4. Positions 3-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6GQP4. 1 interaction.

    Proteomic databases

    PRIDEi Q6GQP4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000067974 ; ENSRNOP00000063486 ; ENSRNOG00000042189 .
    GeneIDi 246324.
    KEGGi rno:246324.

    Organism-specific databases

    CTDi 11031.
    RGDi 628598. Rab31.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00640000091139.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    KOi K07891.
    OMAi IKLGKQT.
    OrthoDBi EOG77DJ7M.
    PhylomeDBi Q6GQP4.
    TreeFami TF331262.

    Miscellaneous databases

    NextBioi 623748.
    PROi Q6GQP4.

    Gene expression databases

    Genevestigatori Q6GQP4.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Visualization in living cells of formation and transport of vesicles: participation of Rab0, an oligodendrocyte protein."
      Rodriguez-Gabin A.G., Cammer M., Almazan G., Charron M.J., Larocca J.N.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments."
      Rodriguez-Gabin A.G., Cammer M., Almazan G., Charron M., Larocca J.N.
      J. Neurosci. Res. 66:1149-1160(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Rab22B's role in trans-Golgi network membrane dynamics."
      Ng E.L., Wang Y., Tang B.L.
      Biochem. Biophys. Res. Commun. 361:751-757(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells."
      Ng E.L., Ng J.J., Liang F., Tang B.L.
      J. Cell. Physiol. 221:716-728(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors."
      Rodriguez-Gabin A.G., Ortiz E., Demoliner K., Si Q., Almazan G., Larocca J.N.
      J. Neurosci. Res. 88:589-604(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH OCRL.

    Entry informationi

    Entry nameiRAB31_RAT
    AccessioniPrimary (citable) accession number: Q6GQP4
    Secondary accession number(s): Q9JK74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3