ID   MECR_DANRE              Reviewed;         377 AA.
AC   Q6GQN8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 2.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Trans-2-enoyl-CoA reductase, mitochondrial;
DE            EC=1.3.1.38;
DE   Flags: Precursor;
GN   Name=mecr; ORFNames=zgc:110153;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-
CC       CoA. May have a role in the mitochondrial synthesis of fatty acids
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA
CC       + NADPH.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily.
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DR   EMBL; BC072704; AAH72704.1; ALT_INIT; mRNA.
DR   IPI; IPI00482679; -.
DR   UniGene; Dr.86428; -.
DR   Ensembl; ENSDARG00000032326; Danio rerio.
DR   ZFIN; ZDB-GENE-050417-399; mecr.
DR   HOGENOM; Q6GQN8; -.
DR   HOVERGEN; Q6GQN8; -.
DR   OMA; Q6GQN8; AYLMLTH.
DR   BRENDA; 1.3.1.38; 96826.
DR   ArrayExpress; Q6GQN8; -.
DR   Bgee; Q6GQN8; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0019166; F:trans-2-enoyl-CoA reductase (NADPH) activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
PE   2: Evidence at transcript level;
KW   Fatty acid biosynthesis; Lipid synthesis; Mitochondrion; NADP;
KW   Oxidoreductase; Transit peptide.
FT   TRANSIT       1     52       Mitochondrion (Potential).
FT   CHAIN        53    377       Trans-2-enoyl-CoA reductase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000000891.
SQ   SEQUENCE   377 AA;  41079 MW;  3FB9E922C6A0EDB2 CRC64;
     MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY RNHGEPSQVV
     QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP ELPAVGGNEG VAQVMEVGDK
     VKTLKVGDWV IPKDAGIGTW RTAAVLKADD LVTLPKDIPV LSAATLGVNP CTAYRMLTDF
     EELKAGDTVI QNAANSGVGQ AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT
     EETLRRPEMK ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS
     ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT QVQLQDFRKA
     LENAMKPYVS TKQVFVM
//