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Q6GQN8

- MECR_DANRE

UniProt

Q6GQN8 - MECR_DANRE

Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

mecr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691NADPBy similarity
    Binding sitei372 – 3721NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 1984NADPBy similarity
    Nucleotide bindingi218 – 2203NADPBy similarity
    Nucleotide bindingi287 – 2904NADPBy similarity
    Nucleotide bindingi312 – 3143NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW
    2. pronephric nephron tubule development Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Gene namesi
    Name:mecr
    ORF Names:zgc:110153
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 16

    Organism-specific databases

    ZFINiZDB-GENE-050417-399. mecr.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5252MitochondrionSequence AnalysisAdd
    BLAST
    Chaini53 – 377325Trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000891Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ6GQN8.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQN8.
    SMRiQ6GQN8. Positions 47-377.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    GeneTreeiENSGT00740000115589.
    HOGENOMiHOG000294683.
    HOVERGENiHBG052446.
    InParanoidiQ6GQN8.
    OMAiKDHSPAQ.
    OrthoDBiEOG78M024.
    PhylomeDBiQ6GQN8.
    TreeFamiTF312886.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6GQN8-1 [UniParc]FASTAAdd to Basket

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    MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY    50
    RNHGEPSQVV QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP 100
    ELPAVGGNEG VAQVMEVGDK VKTLKVGDWV IPKDAGIGTW RTAAVLKADD 150
    LVTLPKDIPV LSAATLGVNP CTAYRMLTDF EELKAGDTVI QNAANSGVGQ 200
    AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT EETLRRPEMK 250
    ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS 300
    ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT 350
    QVQLQDFRKA LENAMKPYVS TKQVFVM 377
    Length:377
    Mass (Da):41,079
    Last modified:April 26, 2005 - v2
    Checksum:i3FB9E922C6A0EDB2
    GO

    Sequence cautioni

    The sequence AAH72704.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072704 mRNA. Translation: AAH72704.1. Different initiation.
    UniGeneiDr.86428.

    Genome annotation databases

    EnsembliENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072704 mRNA. Translation: AAH72704.1 . Different initiation.
    UniGenei Dr.86428.

    3D structure databases

    ProteinModelPortali Q6GQN8.
    SMRi Q6GQN8. Positions 47-377.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000039054 ; ENSDARP00000038801 ; ENSDARG00000032326 .

    Organism-specific databases

    ZFINi ZDB-GENE-050417-399. mecr.

    Phylogenomic databases

    eggNOGi COG0604.
    GeneTreei ENSGT00740000115589.
    HOGENOMi HOG000294683.
    HOVERGENi HBG052446.
    InParanoidi Q6GQN8.
    OMAi KDHSPAQ.
    OrthoDBi EOG78M024.
    PhylomeDBi Q6GQN8.
    TreeFami TF312886.

    Miscellaneous databases

    PROi Q6GQN8.

    Gene expression databases

    Bgeei Q6GQN8.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiMECR_DANRE
    AccessioniPrimary (citable) accession number: Q6GQN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3