Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

mecr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorBy similarity1
Binding sitei169NADPBy similarity1
Binding sitei372NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 198NADPBy similarity4
Nucleotide bindingi218 – 220NADPBy similarity3
Nucleotide bindingi287 – 290NADPBy similarity4
Nucleotide bindingi312 – 314NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)
Alternative name(s):
2-enoyl thioester reductase
Gene namesi
Name:mecr
ORF Names:zgc:110153
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-050417-399. mecr.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000000089153 – 377Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST325

Proteomic databases

PaxDbiQ6GQN8.
PRIDEiQ6GQN8.

Expressioni

Gene expression databases

BgeeiENSDARG00000032326.
ExpressionAtlasiQ6GQN8. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000038801.

Structurei

3D structure databases

ProteinModelPortaliQ6GQN8.
SMRiQ6GQN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0025. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00870000136524.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ6GQN8.
PhylomeDBiQ6GQN8.
TreeFamiTF312886.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY
60 70 80 90 100
RNHGEPSQVV QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP
110 120 130 140 150
ELPAVGGNEG VAQVMEVGDK VKTLKVGDWV IPKDAGIGTW RTAAVLKADD
160 170 180 190 200
LVTLPKDIPV LSAATLGVNP CTAYRMLTDF EELKAGDTVI QNAANSGVGQ
210 220 230 240 250
AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT EETLRRPEMK
260 270 280 290 300
ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS
310 320 330 340 350
ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT
360 370
QVQLQDFRKA LENAMKPYVS TKQVFVM
Length:377
Mass (Da):41,079
Last modified:April 26, 2005 - v2
Checksum:i3FB9E922C6A0EDB2
GO

Sequence cautioni

The sequence AAH72704 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072704 mRNA. Translation: AAH72704.1. Different initiation.
UniGeneiDr.86428.

Genome annotation databases

EnsembliENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072704 mRNA. Translation: AAH72704.1. Different initiation.
UniGeneiDr.86428.

3D structure databases

ProteinModelPortaliQ6GQN8.
SMRiQ6GQN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000038801.

Proteomic databases

PaxDbiQ6GQN8.
PRIDEiQ6GQN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326.

Organism-specific databases

ZFINiZDB-GENE-050417-399. mecr.

Phylogenomic databases

eggNOGiKOG0025. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00870000136524.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ6GQN8.
PhylomeDBiQ6GQN8.
TreeFamiTF312886.

Miscellaneous databases

PROiPR:Q6GQN8.

Gene expression databases

BgeeiENSDARG00000032326.
ExpressionAtlasiQ6GQN8. baseline.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMECR_DANRE
AccessioniPrimary (citable) accession number: Q6GQN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 12, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.