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Q6GQN8

- MECR_DANRE

UniProt

Q6GQN8 - MECR_DANRE

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Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene
mecr, zgc:110153
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei169 – 1691NADP By similarity
Binding sitei372 – 3721NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 1984NADP By similarity
Nucleotide bindingi218 – 2203NADP By similarity
Nucleotide bindingi287 – 2904NADP By similarity
Nucleotide bindingi312 – 3143NADP By similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
  2. pronephric nephron tubule development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:mecr
ORF Names:zgc:110153
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-050417-399. mecr.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5252Mitochondrion Reviewed predictionAdd
BLAST
Chaini53 – 377325Trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000891Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6GQN8.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6GQN8.
SMRiQ6GQN8. Positions 47-377.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ6GQN8.
OMAiKDHSPAQ.
OrthoDBiEOG78M024.
PhylomeDBiQ6GQN8.
TreeFamiTF312886.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQN8-1 [UniParc]FASTAAdd to Basket

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MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY    50
RNHGEPSQVV QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP 100
ELPAVGGNEG VAQVMEVGDK VKTLKVGDWV IPKDAGIGTW RTAAVLKADD 150
LVTLPKDIPV LSAATLGVNP CTAYRMLTDF EELKAGDTVI QNAANSGVGQ 200
AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT EETLRRPEMK 250
ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS 300
ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT 350
QVQLQDFRKA LENAMKPYVS TKQVFVM 377
Length:377
Mass (Da):41,079
Last modified:April 26, 2005 - v2
Checksum:i3FB9E922C6A0EDB2
GO

Sequence cautioni

The sequence AAH72704.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072704 mRNA. Translation: AAH72704.1. Different initiation.
UniGeneiDr.86428.

Genome annotation databases

EnsembliENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072704 mRNA. Translation: AAH72704.1 . Different initiation.
UniGenei Dr.86428.

3D structure databases

ProteinModelPortali Q6GQN8.
SMRi Q6GQN8. Positions 47-377.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000039054 ; ENSDARP00000038801 ; ENSDARG00000032326 .

Organism-specific databases

ZFINi ZDB-GENE-050417-399. mecr.

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00740000115589.
HOGENOMi HOG000294683.
HOVERGENi HBG052446.
InParanoidi Q6GQN8.
OMAi KDHSPAQ.
OrthoDBi EOG78M024.
PhylomeDBi Q6GQN8.
TreeFami TF312886.

Miscellaneous databases

PROi Q6GQN8.

Gene expression databases

Bgeei Q6GQN8.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMECR_DANRE
AccessioniPrimary (citable) accession number: Q6GQN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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