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Q6GQN8 (MECR_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:mecr
ORF Names:zgc:110153
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Sequence caution

The sequence AAH72704.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5252Mitochondrion Potential
Chain53 – 377325Trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000000891

Regions

Nucleotide binding195 – 1984NADP By similarity
Nucleotide binding218 – 2203NADP By similarity
Nucleotide binding287 – 2904NADP By similarity
Nucleotide binding312 – 3143NADP By similarity

Sites

Binding site1691NADP By similarity
Binding site3721NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GQN8 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 3FB9E922C6A0EDB2

FASTA37741,079
        10         20         30         40         50         60 
MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY RNHGEPSQVV 

        70         80         90        100        110        120 
QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP ELPAVGGNEG VAQVMEVGDK 

       130        140        150        160        170        180 
VKTLKVGDWV IPKDAGIGTW RTAAVLKADD LVTLPKDIPV LSAATLGVNP CTAYRMLTDF 

       190        200        210        220        230        240 
EELKAGDTVI QNAANSGVGQ AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT 

       250        260        270        280        290        300 
EETLRRPEMK ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS 

       310        320        330        340        350        360 
ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT QVQLQDFRKA 

       370 
LENAMKPYVS TKQVFVM 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC072704 mRNA. Translation: AAH72704.1. Different initiation.
UniGeneDr.86428.

3D structure databases

ProteinModelPortalQ6GQN8.
SMRQ6GQN8. Positions 47-377.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326.

Organism-specific databases

ZFINZDB-GENE-050417-399. mecr.

Phylogenomic databases

eggNOGCOG0604.
GeneTreeENSGT00740000115589.
HOGENOMHOG000294683.
HOVERGENHBG052446.
InParanoidQ6GQN8.
OMAKDHSPAQ.
OrthoDBEOG78M024.
PhylomeDBQ6GQN8.
TreeFamTF312886.

Gene expression databases

BgeeQ6GQN8.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Other

PROQ6GQN8.

Entry information

Entry nameMECR_DANRE
AccessionPrimary (citable) accession number: Q6GQN8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families