Reviewed, UniProtKB/Swiss-Prot Q6GQN8 (MECR_DANRE)

Names and origin

Protein names

Recommended name:
    Trans-2-enoyl-CoA reductase, mitochondrial
    EC=1.3.1.38

Gene names

Name:	mecr
ORF Names:	zgc:110153

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	MitochondrionBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion Potential
	Chain	53 – 377	325	Trans-2-enoyl-CoA reductase, mitochondrial		PRO_0000000891

Sequences

	Sequence		Length	Mass (Da)
	Q6GQN8-1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: 3FB9E922C6A0EDB2	FASTA	377	41,079
	10 20 30 40 50 60 MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY RNHGEPSQVV 70 80 90 100 110 120 QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP ELPAVGGNEG VAQVMEVGDK 130 140 150 160 170 180 VKTLKVGDWV IPKDAGIGTW RTAAVLKADD LVTLPKDIPV LSAATLGVNP CTAYRMLTDF 190 200 210 220 230 240 EELKAGDTVI QNAANSGVGQ AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT 250 260 270 280 290 300 EETLRRPEMK ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS 310 320 330 340 350 360 ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT QVQLQDFRKA 370 LENAMKPYVS TKQVFVM

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC072704 mRNA. Translation: AAH72704.1. Different initiation.
UniGene	Dr.86428
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000032326. Danio rerio. [Contig view]
Organism-specific databases
ZFIN	ZDB-GENE-050417-399. mecr.
Phylogenomic databases
HOGENOM	Q6GQN8.
HOVERGEN	Q6GQN8.
Gene expression databases
ArrayExpress	Q6GQN8.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MECR_DANRE

Accession

Primary (citable) accession number: Q6GQN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project