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Q6GQL0

- CBLBA_XENLA

UniProt

Q6GQL0 - CBLBA_XENLA

Protein

E3 ubiquitin-protein ligase CBL-B-A

Gene

cblb-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei297 – 2971PhosphotyrosineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi230 – 24314PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 42340RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. ligase activity Source: UniProtKB-KW
    3. signal transducer activity Source: InterPro
    4. ubiquitin-protein transferase activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: InterPro
    2. immune system process Source: UniProtKB-KW
    3. regulation of signaling Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Immunity, Ubl conjugation pathway

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase CBL-B-A (EC:6.3.2.-)
    Alternative name(s):
    SH3-binding protein CBL-B-A
    Signal transduction protein CBL-B-A
    Gene namesi
    Name:cblb-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6251733. cblb.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 918918E3 ubiquitin-protein ligase CBL-B-APRO_0000055863Add
    BLAST

    Proteomic databases

    PRIDEiQ6GQL0.

    Interactioni

    Subunit structurei

    Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQL0.
    SMRiQ6GQL0. Positions 46-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 354309Cbl-PTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni46 – 1781334HAdd
    BLAST
    Regioni179 – 25173EF-hand-likeAdd
    BLAST
    Regioni252 – 354103SH2-likeAdd
    BLAST
    Regioni355 – 38329LinkerAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi487 – 57690Pro-richAdd
    BLAST
    Compositional biasi809 – 87365Pro-richAdd
    BLAST

    Domaini

    The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
    The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

    Sequence similaritiesi

    Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri384 – 42340RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG005255.
    KOiK04707.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.20.930.20. 1 hit.
    3.30.40.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR024162. Adaptor_Cbl.
    IPR014741. Adaptor_Cbl_EF_hand-like.
    IPR003153. Adaptor_Cbl_N_hlx.
    IPR014742. Adaptor_Cbl_SH2-like.
    IPR024159. Cbl_PTB.
    IPR011992. EF-hand-dom_pair.
    IPR000980. SH2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PANTHERiPTHR23007. PTHR23007. 1 hit.
    PfamiPF02262. Cbl_N. 1 hit.
    PF02761. Cbl_N2. 1 hit.
    PF02762. Cbl_N3. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47668. SSF47668. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS51506. CBL_PTB. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GQL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGSGSSSS TSSSALSGRL PGSRSANPRK ARILGLFDAI QDAVGPPKQA    50
    AADRRTVEKT WKLMDKVVRL CQNPKLQLKN SPPYILDILP DTYQHLRLIL 100
    SKYDDNQKLA QLSENEYFKI YIDSLIKKSK RAMRLFKEGK ERMYEEQSQE 150
    RRNLTKLSLI FSHMLAEIKA IFPSGQFQGD NFRITKADAA EFWRKFFGER 200
    TIVPWKIFRQ CLHEVHQISS GLEAMALKST IDLTCNDYIS VFEFDIFTRL 250
    FQPWGSILRN WNFLAVTHPG YMAFLTYDEV KARLQKYSLK PGSYIFRLSC 300
    TRLGQWAIGY VTADGNILQT IPHNKPLFQA LIDGSREGFY LYPDGRSYNP 350
    DLTGLCEPTP HDHIKVTQEQ YELYCEMGST FQLCKICAEN DKDVKIEPCG 400
    HLMCTSCLTS WQESDGQGCP FCRCEIKGME PIIVDPFDPR DESRCFSFSD 450
    SLCTPMLDFD DDDLREECLI MNRLAALRKM NERQNSPVTS PGSSPLSQRR 500
    KTPPEPLQIP HLNLPPVPPR LDLIQKGLAR SPCASPTGSP KSSPCMVRKQ 550
    DKPLPAPPPL LREPPPPPER PPPIPPDSRT CRHLHHADNV PCRDQSTPHE 600
    AWCTRDLSGG NPASVCRVTH DGSPKLGVPS SSVLNGRHSR MSTEAGFMRH 650
    KHHKRRESPL ETLRVYNGLS GNEEYDVPPR LSPPTITIHP IVKCPVLVNS 700
    VSDKVRNSAE EDDCEYKIPS SHPVSSRLPL HCHSIKHFPR LCENGQCLSN 750
    GTHNGISEIK KLKPPDQGDV IATSTVPIHF PPARTSAREN HPHGSSLTRT 800
    PSDYDLLVPH PGEESFDISP PSQPPPPPPA RTCVTEHVMP TALGSRPNSD 850
    VDLFLPHSDP CPEAPLPPAR RGPGEVKSNR LSQEYDQLPS CPGKGQEKAS 900
    NTKGELLLPN QNLIMRPT 918
    Length:918
    Mass (Da):102,831
    Last modified:July 19, 2004 - v1
    Checksum:i5CEB1FDCBCE9D572
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072732 mRNA. Translation: AAH72732.1.
    RefSeqiNP_001085428.1. NM_001091959.1.
    UniGeneiXl.65637.

    Genome annotation databases

    GeneIDi443854.
    KEGGixla:443854.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072732 mRNA. Translation: AAH72732.1 .
    RefSeqi NP_001085428.1. NM_001091959.1.
    UniGenei Xl.65637.

    3D structure databases

    ProteinModelPortali Q6GQL0.
    SMRi Q6GQL0. Positions 46-437.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6GQL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443854.
    KEGGi xla:443854.

    Organism-specific databases

    CTDi 443854.
    Xenbasei XB-GENE-6251733. cblb.

    Phylogenomic databases

    HOVERGENi HBG005255.
    KOi K04707.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.20.930.20. 1 hit.
    3.30.40.10. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR024162. Adaptor_Cbl.
    IPR014741. Adaptor_Cbl_EF_hand-like.
    IPR003153. Adaptor_Cbl_N_hlx.
    IPR014742. Adaptor_Cbl_SH2-like.
    IPR024159. Cbl_PTB.
    IPR011992. EF-hand-dom_pair.
    IPR000980. SH2.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    PANTHERi PTHR23007. PTHR23007. 1 hit.
    Pfami PF02262. Cbl_N. 1 hit.
    PF02761. Cbl_N2. 1 hit.
    PF02762. Cbl_N3. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47668. SSF47668. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS51506. CBL_PTB. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCBLBA_XENLA
    AccessioniPrimary (citable) accession number: Q6GQL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein has one functional calcium-binding site.By similarity

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3