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Q6GQJ7 (SYRM_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable arginine--tRNA ligase, mitochondrial

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:rars2
Synonyms:rarsl
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1616Mitochondrion Potential
Chain17 – 580564Probable arginine--tRNA ligase, mitochondrial
PRO_0000250734

Regions

Motif136 – 14712"HIGH" region

Sequences

Sequence LengthMass (Da)Tools
Q6GQJ7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 5927ED86B0DA6F64

FASTA58065,426
        10         20         30         40         50         60 
MAWHFRRVIA EQVSRVLGLP SESCSRVAQC IQTVPVHRKH ESPDFQLFMT SLSEGGPNGT 

        70         80         90        100        110        120 
FSNQEERAEQ LAGKLVCDSV ISDIGTTRGS VTFKINRDLL TRNVLQQISK DGSLYGLNTE 

       130        140        150        160        170        180 
LFSELSRRKT IVEYSSPNIA KKFHVGHLRS TIIGNFIANL KQAVGNEVVR INYLGDWGLQ 

       190        200        210        220        230        240 
FGLLGAGFSS FGSKEKLLAN PLQHLFEVYV KVNTAAEKDN GIKLSAQEFL RRLEGGDPHA 

       250        260        270        280        290        300 
LSLWMHFRDI SIQEYAKIYK RLGAHFDDYS GESFYKEKSQ EVLKQLESKG LLLKTDKGTV 

       310        320        330        340        350        360 
IDLSEEGNLS SYSTVMRSDG TSLYITRDMA AAVDRMERYN FDEMIYVTDK SQKNHFQQLF 

       370        380        390        400        410        420 
KILKIMGKDQ ADRCQHVPFG LVQGMKTRRG EVVFLEDVLD EARSRMLQNM AASETSKQLD 

       430        440        450        460        470        480 
DPSDTAEKIG IAALIVQDFK GQLVSDYHFD WDQALQSTGD TGVFLQYTHA RLHSLQALRC 

       490        500        510        520        530        540 
PRDTEDFEIA SLREPCVIAT LQHLLRYDEV IYKCLEDLQP RYLVTYLLSL GHLANVAHRT 

       550        560        570        580 
LQVKGSSSEA AHARLLFFKN VQMVLGNGMK LLGITPVNNM 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC072745 mRNA. Translation: AAH72745.1.
RefSeqNP_001085437.1. NM_001091968.1.
UniGeneXl.9786.

3D structure databases

ProteinModelPortalQ6GQJ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6GQJ7. 1 interaction.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443863.
KEGGxla:443863.

Organism-specific databases

CTD57038.
XenbaseXB-GENE-976893. rars2.

Phylogenomic databases

HOVERGENHBG057355.
KOK01887.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYRM_XENLA
AccessionPrimary (citable) accession number: Q6GQJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries