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Protein

Probable arginine--tRNA ligase, mitochondrial

Gene

rars2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rars2
Synonyms:rarsl
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-976893. rars2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000025073417 – 580Probable arginine--tRNA ligase, mitochondrialAdd BLAST564

Interactioni

Protein-protein interaction databases

IntActiQ6GQJ7. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6GQJ7.
SMRiQ6GQJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 147"HIGH" regionAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG057355.
KOiK01887.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWHFRRVIA EQVSRVLGLP SESCSRVAQC IQTVPVHRKH ESPDFQLFMT
60 70 80 90 100
SLSEGGPNGT FSNQEERAEQ LAGKLVCDSV ISDIGTTRGS VTFKINRDLL
110 120 130 140 150
TRNVLQQISK DGSLYGLNTE LFSELSRRKT IVEYSSPNIA KKFHVGHLRS
160 170 180 190 200
TIIGNFIANL KQAVGNEVVR INYLGDWGLQ FGLLGAGFSS FGSKEKLLAN
210 220 230 240 250
PLQHLFEVYV KVNTAAEKDN GIKLSAQEFL RRLEGGDPHA LSLWMHFRDI
260 270 280 290 300
SIQEYAKIYK RLGAHFDDYS GESFYKEKSQ EVLKQLESKG LLLKTDKGTV
310 320 330 340 350
IDLSEEGNLS SYSTVMRSDG TSLYITRDMA AAVDRMERYN FDEMIYVTDK
360 370 380 390 400
SQKNHFQQLF KILKIMGKDQ ADRCQHVPFG LVQGMKTRRG EVVFLEDVLD
410 420 430 440 450
EARSRMLQNM AASETSKQLD DPSDTAEKIG IAALIVQDFK GQLVSDYHFD
460 470 480 490 500
WDQALQSTGD TGVFLQYTHA RLHSLQALRC PRDTEDFEIA SLREPCVIAT
510 520 530 540 550
LQHLLRYDEV IYKCLEDLQP RYLVTYLLSL GHLANVAHRT LQVKGSSSEA
560 570 580
AHARLLFFKN VQMVLGNGMK LLGITPVNNM
Length:580
Mass (Da):65,426
Last modified:July 19, 2004 - v1
Checksum:i5927ED86B0DA6F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072745 mRNA. Translation: AAH72745.1.
RefSeqiNP_001085437.1. NM_001091968.1.
UniGeneiXl.9786.

Genome annotation databases

GeneIDi443863.
KEGGixla:443863.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSYRM_XENLA
AccessioniPrimary (citable) accession number: Q6GQJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 19, 2004
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families