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Q6GQJ7

- SYRM_XENLA

UniProt

Q6GQJ7 - SYRM_XENLA

Protein

Probable arginine--tRNA ligase, mitochondrial

Gene

rars2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:rars2
    Synonyms:rarsl
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-976893. rars2.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1616MitochondrionSequence AnalysisAdd
    BLAST
    Chaini17 – 580564Probable arginine--tRNA ligase, mitochondrialPRO_0000250734Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ6GQJ7. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQJ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi136 – 14712"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG057355.
    KOiK01887.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6GQJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWHFRRVIA EQVSRVLGLP SESCSRVAQC IQTVPVHRKH ESPDFQLFMT    50
    SLSEGGPNGT FSNQEERAEQ LAGKLVCDSV ISDIGTTRGS VTFKINRDLL 100
    TRNVLQQISK DGSLYGLNTE LFSELSRRKT IVEYSSPNIA KKFHVGHLRS 150
    TIIGNFIANL KQAVGNEVVR INYLGDWGLQ FGLLGAGFSS FGSKEKLLAN 200
    PLQHLFEVYV KVNTAAEKDN GIKLSAQEFL RRLEGGDPHA LSLWMHFRDI 250
    SIQEYAKIYK RLGAHFDDYS GESFYKEKSQ EVLKQLESKG LLLKTDKGTV 300
    IDLSEEGNLS SYSTVMRSDG TSLYITRDMA AAVDRMERYN FDEMIYVTDK 350
    SQKNHFQQLF KILKIMGKDQ ADRCQHVPFG LVQGMKTRRG EVVFLEDVLD 400
    EARSRMLQNM AASETSKQLD DPSDTAEKIG IAALIVQDFK GQLVSDYHFD 450
    WDQALQSTGD TGVFLQYTHA RLHSLQALRC PRDTEDFEIA SLREPCVIAT 500
    LQHLLRYDEV IYKCLEDLQP RYLVTYLLSL GHLANVAHRT LQVKGSSSEA 550
    AHARLLFFKN VQMVLGNGMK LLGITPVNNM 580
    Length:580
    Mass (Da):65,426
    Last modified:July 19, 2004 - v1
    Checksum:i5927ED86B0DA6F64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072745 mRNA. Translation: AAH72745.1.
    RefSeqiNP_001085437.1. NM_001091968.1.
    UniGeneiXl.9786.

    Genome annotation databases

    GeneIDi443863.
    KEGGixla:443863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072745 mRNA. Translation: AAH72745.1 .
    RefSeqi NP_001085437.1. NM_001091968.1.
    UniGenei Xl.9786.

    3D structure databases

    ProteinModelPortali Q6GQJ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6GQJ7. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443863.
    KEGGi xla:443863.

    Organism-specific databases

    CTDi 57038.
    Xenbasei XB-GENE-976893. rars2.

    Phylogenomic databases

    HOVERGENi HBG057355.
    KOi K01887.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiSYRM_XENLA
    AccessioniPrimary (citable) accession number: Q6GQJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3