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Protein

Probable arginine--tRNA ligase, mitochondrial

Gene

rars2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rars2
Synonyms:rarsl
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-976893. rars2.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616MitochondrionSequence AnalysisAdd
BLAST
Chaini17 – 580564Probable arginine--tRNA ligase, mitochondrialPRO_0000250734Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ6GQJ7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6GQJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi136 – 14712"HIGH" regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG057355.
KOiK01887.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWHFRRVIA EQVSRVLGLP SESCSRVAQC IQTVPVHRKH ESPDFQLFMT
60 70 80 90 100
SLSEGGPNGT FSNQEERAEQ LAGKLVCDSV ISDIGTTRGS VTFKINRDLL
110 120 130 140 150
TRNVLQQISK DGSLYGLNTE LFSELSRRKT IVEYSSPNIA KKFHVGHLRS
160 170 180 190 200
TIIGNFIANL KQAVGNEVVR INYLGDWGLQ FGLLGAGFSS FGSKEKLLAN
210 220 230 240 250
PLQHLFEVYV KVNTAAEKDN GIKLSAQEFL RRLEGGDPHA LSLWMHFRDI
260 270 280 290 300
SIQEYAKIYK RLGAHFDDYS GESFYKEKSQ EVLKQLESKG LLLKTDKGTV
310 320 330 340 350
IDLSEEGNLS SYSTVMRSDG TSLYITRDMA AAVDRMERYN FDEMIYVTDK
360 370 380 390 400
SQKNHFQQLF KILKIMGKDQ ADRCQHVPFG LVQGMKTRRG EVVFLEDVLD
410 420 430 440 450
EARSRMLQNM AASETSKQLD DPSDTAEKIG IAALIVQDFK GQLVSDYHFD
460 470 480 490 500
WDQALQSTGD TGVFLQYTHA RLHSLQALRC PRDTEDFEIA SLREPCVIAT
510 520 530 540 550
LQHLLRYDEV IYKCLEDLQP RYLVTYLLSL GHLANVAHRT LQVKGSSSEA
560 570 580
AHARLLFFKN VQMVLGNGMK LLGITPVNNM
Length:580
Mass (Da):65,426
Last modified:July 19, 2004 - v1
Checksum:i5927ED86B0DA6F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072745 mRNA. Translation: AAH72745.1.
RefSeqiNP_001085437.1. NM_001091968.1.
UniGeneiXl.9786.

Genome annotation databases

GeneIDi443863.
KEGGixla:443863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072745 mRNA. Translation: AAH72745.1.
RefSeqiNP_001085437.1. NM_001091968.1.
UniGeneiXl.9786.

3D structure databases

ProteinModelPortaliQ6GQJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6GQJ7. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443863.
KEGGixla:443863.

Organism-specific databases

CTDi57038.
XenbaseiXB-GENE-976893. rars2.

Phylogenomic databases

HOVERGENiHBG057355.
KOiK01887.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiSYRM_XENLA
AccessioniPrimary (citable) accession number: Q6GQJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.