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Q6GQJ7

- SYRM_XENLA

UniProt

Q6GQJ7 - SYRM_XENLA

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Protein

Probable arginine--tRNA ligase, mitochondrial

Gene
rars2, rarsl
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, mitochondrial (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:rars2
Synonyms:rarsl
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-976893. rars2.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616Mitochondrion Reviewed predictionAdd
BLAST
Chaini17 – 580564Probable arginine--tRNA ligase, mitochondrialPRO_0000250734Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ6GQJ7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6GQJ7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi136 – 14712"HIGH" regionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG057355.
KOiK01887.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQJ7-1 [UniParc]FASTAAdd to Basket

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MAWHFRRVIA EQVSRVLGLP SESCSRVAQC IQTVPVHRKH ESPDFQLFMT    50
SLSEGGPNGT FSNQEERAEQ LAGKLVCDSV ISDIGTTRGS VTFKINRDLL 100
TRNVLQQISK DGSLYGLNTE LFSELSRRKT IVEYSSPNIA KKFHVGHLRS 150
TIIGNFIANL KQAVGNEVVR INYLGDWGLQ FGLLGAGFSS FGSKEKLLAN 200
PLQHLFEVYV KVNTAAEKDN GIKLSAQEFL RRLEGGDPHA LSLWMHFRDI 250
SIQEYAKIYK RLGAHFDDYS GESFYKEKSQ EVLKQLESKG LLLKTDKGTV 300
IDLSEEGNLS SYSTVMRSDG TSLYITRDMA AAVDRMERYN FDEMIYVTDK 350
SQKNHFQQLF KILKIMGKDQ ADRCQHVPFG LVQGMKTRRG EVVFLEDVLD 400
EARSRMLQNM AASETSKQLD DPSDTAEKIG IAALIVQDFK GQLVSDYHFD 450
WDQALQSTGD TGVFLQYTHA RLHSLQALRC PRDTEDFEIA SLREPCVIAT 500
LQHLLRYDEV IYKCLEDLQP RYLVTYLLSL GHLANVAHRT LQVKGSSSEA 550
AHARLLFFKN VQMVLGNGMK LLGITPVNNM 580
Length:580
Mass (Da):65,426
Last modified:July 19, 2004 - v1
Checksum:i5927ED86B0DA6F64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072745 mRNA. Translation: AAH72745.1.
RefSeqiNP_001085437.1. NM_001091968.1.
UniGeneiXl.9786.

Genome annotation databases

GeneIDi443863.
KEGGixla:443863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072745 mRNA. Translation: AAH72745.1 .
RefSeqi NP_001085437.1. NM_001091968.1.
UniGenei Xl.9786.

3D structure databases

ProteinModelPortali Q6GQJ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6GQJ7. 1 interaction.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443863.
KEGGi xla:443863.

Organism-specific databases

CTDi 57038.
Xenbasei XB-GENE-976893. rars2.

Phylogenomic databases

HOVERGENi HBG057355.
KOi K01887.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiSYRM_XENLA
AccessioniPrimary (citable) accession number: Q6GQJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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