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Q6GQJ4

- Q6GQJ4_XENLA

UniProt

Q6GQJ4 - Q6GQJ4_XENLA

Protein
Submitted name:

C-raf protein

Gene

raf1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. receptor signaling protein activity Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding, ZincSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    C-raf proteinImported
    Gene namesi
    Name:raf1Imported
    Synonyms:c-rafImported
    OrganismiXenopus laevis (African clawed frog)Imported
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6053397. raf1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQJ4.
    SMRiQ6GQJ4. Positions 55-131, 135-186, 333-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG001886.
    KOiK04366.

    Family and domain databases

    InterProiIPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR003116. Raf-like_ras-bd.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF02196. RBD. 1 hit.
    [Graphical view]
    PRINTSiPR00008. DAGPEDOMAIN.
    SMARTiSM00109. C1. 1 hit.
    SM00455. RBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50898. RBD. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GQJ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHIQGAWKT LSNGFGFKES VFEGSSCMSP TIGHQFGYQR RASDDGKLSD    50
    TSKTSSTMRV YLPNKQRTVV NVRSGMSLHD CLMKSLKVRG LQPECCAVFR 100
    LIQDPKGKLR LDWNTDAMSL VGAELQVDFL DHVPLTTHNF VRKTFLKLAF 150
    CDICQKFLLN GFRCQTCGYK FHEHCSTKVP TMCVDWSNIR QLLLFPNPNN 200
    IEGGSHTLPS LTMRRMRESV RIPVSSQQRY STPHPFSFST PSPVSECSLS 250
    QRQRSTSTPN VHMVSTTMAV DSRVIEDALR SHSESGSPNN LSPTGWSNAK 300
    APAPTHREKA ASSTGQEKNK IRPRGQRDSS YYWEIEASEV MLSSRIGSGS 350
    FGTVYKGKWH GDVAVKILKV TDPTPEQLQA FRNEVAVLRK TRHVNILLFM 400
    GYMTKDNLAI VTQWCEGSSL YYHLHVLDTK FQMFQLIDIA RQTAQGMDYL 450
    HAKNIIHRDM KSNNIFLHEG LTVKIGDFGL ATVKTRWSGS QQVEQLTGSI 500
    LWMAPEVIRM QDNNPFSFQS DVYSYGIVLY ELMTGELPYS HIRDRDQIIF 550
    LVGRGGVVPD LSKLYKNCPK AMKRLVADSI KKLRDERPLF PQILSSIELL 600
    QHSLPKINRS ASEPSLHRAA HTEDISSCAL TSTRLPVF 638
    Length:638
    Mass (Da):72,036
    Last modified:July 19, 2004 - v1
    Checksum:i9C9B2BA650E2BCC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072748 mRNA. Translation: AAH72748.1.
    RefSeqiNP_001081475.1. NM_001088006.1.
    UniGeneiXl.5697.

    Genome annotation databases

    GeneIDi397857.
    KEGGixla:397857.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072748 mRNA. Translation: AAH72748.1 .
    RefSeqi NP_001081475.1. NM_001088006.1.
    UniGenei Xl.5697.

    3D structure databases

    ProteinModelPortali Q6GQJ4.
    SMRi Q6GQJ4. Positions 55-131, 135-186, 333-606.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397857.
    KEGGi xla:397857.

    Organism-specific databases

    CTDi 397857.
    Xenbasei XB-GENE-6053397. raf1.

    Phylogenomic databases

    HOVERGENi HBG001886.
    KOi K04366.

    Family and domain databases

    InterProi IPR020454. DAG/PE-bd.
    IPR011009. Kinase-like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR003116. Raf-like_ras-bd.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF02196. RBD. 1 hit.
    [Graphical view ]
    PRINTSi PR00008. DAGPEDOMAIN.
    SMARTi SM00109. C1. 1 hit.
    SM00455. RBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50898. RBD. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: OvaryImported.

    Entry informationi

    Entry nameiQ6GQJ4_XENLA
    AccessioniPrimary (citable) accession number: Q6GQJ4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)