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Q6GQD5

- RN146_XENLA

UniProt

Q6GQD5 - RN146_XENLA

Protein

E3 ubiquitin-protein ligase rnf146

Gene

rnf146

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071iso-ADP-ribose adenine ring groupBy similarity
    Binding sitei110 – 1101iso-ADP-ribose 5'-phosphate groupBy similarity
    Binding sitei114 – 1141iso-ADP-ribose 5'-phosphate groupBy similarity
    Binding sitei144 – 1441iso-ADP-ribose 1'-phosphate groupBy similarity
    Binding sitei153 – 1531iso-ADP-ribose adenine ring groupBy similarity
    Binding sitei163 – 1631iso-ADP-ribose 1'-phosphate groupBy similarity
    Binding sitei175 – 1751iso-ADP-ribose 5'-phosphate groupBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri36 – 7439RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. poly-ADP-D-ribose binding Source: UniProtKB
    3. ubiquitin-protein transferase activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    2. protein autoubiquitination Source: UniProtKB
    3. protein K48-linked ubiquitination Source: UniProtKB
    4. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway, Wnt signaling pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase rnf146 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 146
    Gene namesi
    Name:rnf146
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-974784. rnf146.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: Translocates to the nucleus after DNA damage.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314E3 ubiquitin-protein ligase rnf146PRO_0000409507Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQD5.
    SMRiQ6GQD5. Positions 26-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 16777WWEPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The WWE domain mediates non-covalent poly(ADP-ribose)-binding.By similarity

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 WWE domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri36 – 7439RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG057514.
    KOiK15700.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004170. WWE-dom.
    IPR018123. WWE-dom_subgr.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF02825. WWE. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00678. WWE. 1 hit.
    [Graphical view]
    PROSITEiPS50918. WWE. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GQD5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGCGEVSHS ANMLPTNKKL DEPCSNNAPS LSVPECAICL QICVHPVSLP    50
    CKHIFCYLCV KGASWLGRRC ALCRQEIPED FLDKPTLLSP EDLKSASRGN 100
    GEYAWYYEGR NGWWQYDERT SRELEDAFTK GKKSTEMLIA GFLYVADLEN 150
    MVQYRRNEHG RRRKIKRDIV DIPKKGVAGL RLECDAANLN LARESSADGA 200
    DSMAALGDSS SQPAHVLPAR LHTSLSTTTS QVLSHSDVTT SLENSFTQLQ 250
    IGDPVINRNY IGEEGRPLII ARMQATNAVL EEQEPSDRND HGSPALQHNS 300
    FLVPQSNRLP FGNP 314
    Length:314
    Mass (Da):34,771
    Last modified:July 19, 2004 - v1
    Checksum:i3FAF256C14E0F227
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072810 mRNA. Translation: AAH72810.1.
    RefSeqiNP_001085469.1. NM_001092000.1.
    UniGeneiXl.14626.

    Genome annotation databases

    GeneIDi443895.
    KEGGixla:443895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072810 mRNA. Translation: AAH72810.1 .
    RefSeqi NP_001085469.1. NM_001092000.1.
    UniGenei Xl.14626.

    3D structure databases

    ProteinModelPortali Q6GQD5.
    SMRi Q6GQD5. Positions 26-179.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443895.
    KEGGi xla:443895.

    Organism-specific databases

    CTDi 81847.
    Xenbasei XB-GENE-974784. rnf146.

    Phylogenomic databases

    HOVERGENi HBG057514.
    KOi K15700.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004170. WWE-dom.
    IPR018123. WWE-dom_subgr.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF02825. WWE. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00678. WWE. 1 hit.
    [Graphical view ]
    PROSITEi PS50918. WWE. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiRN146_XENLA
    AccessioniPrimary (citable) accession number: Q6GQD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 31, 2011
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3