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Q6GQD5 (RN146_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase rnf146

EC=6.3.2.-
Alternative name(s):
RING finger protein 146
Gene names
Name:rnf146
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair By similarity.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasmcytosol By similarity. Nucleus By similarity. Note: Translocates to the nucleus after DNA damage By similarity.

Domain

The WWE domain mediates non-covalent poly(ADP-ribose)-binding By similarity.

Sequence similarities

Contains 1 RING-type zinc finger.

Contains 1 WWE domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314E3 ubiquitin-protein ligase rnf146
PRO_0000409507

Regions

Domain91 – 16777WWE
Zinc finger36 – 7439RING-type

Sites

Binding site1071iso-ADP-ribose adenine ring group By similarity
Binding site1101iso-ADP-ribose 5'-phosphate group By similarity
Binding site1141iso-ADP-ribose 5'-phosphate group By similarity
Binding site1441iso-ADP-ribose 1'-phosphate group By similarity
Binding site1531iso-ADP-ribose adenine ring group By similarity
Binding site1631iso-ADP-ribose 1'-phosphate group By similarity
Binding site1751iso-ADP-ribose 5'-phosphate group By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GQD5 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 3FAF256C14E0F227

FASTA31434,771
        10         20         30         40         50         60 
MAGCGEVSHS ANMLPTNKKL DEPCSNNAPS LSVPECAICL QICVHPVSLP CKHIFCYLCV 

        70         80         90        100        110        120 
KGASWLGRRC ALCRQEIPED FLDKPTLLSP EDLKSASRGN GEYAWYYEGR NGWWQYDERT 

       130        140        150        160        170        180 
SRELEDAFTK GKKSTEMLIA GFLYVADLEN MVQYRRNEHG RRRKIKRDIV DIPKKGVAGL 

       190        200        210        220        230        240 
RLECDAANLN LARESSADGA DSMAALGDSS SQPAHVLPAR LHTSLSTTTS QVLSHSDVTT 

       250        260        270        280        290        300 
SLENSFTQLQ IGDPVINRNY IGEEGRPLII ARMQATNAVL EEQEPSDRND HGSPALQHNS 

       310 
FLVPQSNRLP FGNP 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC072810 mRNA. Translation: AAH72810.1.
RefSeqNP_001085469.1. NM_001092000.1.
UniGeneXl.14626.

3D structure databases

ProteinModelPortalQ6GQD5.
SMRQ6GQD5. Positions 26-179.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443895.
KEGGxla:443895.

Organism-specific databases

CTD81847.
XenbaseXB-GENE-974784. rnf146.

Phylogenomic databases

HOVERGENHBG057514.
KOK15700.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF02825. WWE. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00678. WWE. 1 hit.
[Graphical view]
PROSITEPS50918. WWE. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRN146_XENLA
AccessionPrimary (citable) accession number: Q6GQD5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways