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Q6GQB9

- EDEM3_XENLA

UniProt

Q6GQB9 - EDEM3_XENLA

Protein

ER degradation-enhancing alpha-mannosidase-like protein 3

Gene

edem3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    May be involved in endoplasmic reticulum-associated degradation (ERAD).By similarity

    Catalytic activityi

    Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321Proton donorBy similarity
    Active sitei279 – 2791By similarity
    Active sitei391 – 3911By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to unfolded protein Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Unfolded protein response

    Protein family/group databases

    CAZyiGH47. Glycoside Hydrolase Family 47.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER degradation-enhancing alpha-mannosidase-like protein 3 (EC:3.2.1.113)
    Alternative name(s):
    Alpha-1,2-mannosidase EDEM3
    Gene namesi
    Name:edem3
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5811512. edem3.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 913898ER degradation-enhancing alpha-mannosidase-like protein 3PRO_0000364227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GQB9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini660 – 766107PAAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi910 – 9134Prevents secretion from ERPROSITE-ProRule annotation

    Domaini

    Contains a protease-associated domain (PA) of unknown function.By similarity

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 47 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG107835.
    KOiK10086.

    Family and domain databases

    Gene3Di1.50.10.50. 1 hit.
    InterProiIPR001382. Glyco_hydro_47.
    IPR003137. Protease-assoc_domain.
    [Graphical view]
    PANTHERiPTHR11742. PTHR11742. 1 hit.
    PfamiPF01532. Glyco_hydro_47. 1 hit.
    PF02225. PA. 1 hit.
    [Graphical view]
    PRINTSiPR00747. GLYHDRLASE47.
    SUPFAMiSSF48225. SSF48225. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6GQB9-1 [UniParc]FASTAAdd to Basket

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    MGCPAVEARR WGDMWLVVAF CLLGHGHAAV TKEEKAHLRS QVLEMFDHAY    50
    GNYMQHAYPA DELMPLTCRG RIRGQEPSRG DVDDALGKFS LTLIDTLDTL 100
    VVLNKTKEFE DAVRKVITDV NLDNDIVVSV FETNIRVLGG LLGGHSVAIM 150
    LKENGDGMQW YNDELLHMAK ELGYKLLPAF NTTSGLPYPR INLKFGIRRP 200
    EARTGTETDT CTACAGTMIL EFAALSRFTG ISVFEEHARK ALDFLWDKRQ 250
    RSSNLVGVTI NIHTGDWVRK DSGVGAGIDS YYEYLLKAYV LLGDDSYLER 300
    FNTHYDAIMR YISQPPLLLD VHIHKPMLTA RTWMDSLLAF FPGLQVLKGD 350
    IRPAIETHEM LYQVIKKHNF LPEAFTTDFR VHWAQHPLRP EFAESTYFLY 400
    KATGDPYYLE VGKTLIDNLN KYARVPCGFA AVKDVRTGSH EDRMDSFFLA 450
    EMFKYLYLLF SEREDLIFDI EDYIFTTEAH LLPLSLSTAN PSSTKKNTTT 500
    QYTELDDSNF DWSCPNTQIL FRNDPMYAQN IREPLKNVVD KNCPRSPSRL 550
    DEISGSGKMP PLRARDFMAS NSEHLEILKK MGVSLIHLKD GRVQLVQHAN 600
    QAASSIDAED GLRFMQEMIE LSSQQQKEQQ LPPRAVQIVS HPFYGRVVLT 650
    AGPAQFGMDL SKHLAGAQGL VARAEPYSGC SDITNGQAIQ GKIALMQRGQ 700
    CMFAEKARNV QKAGAIGGIV IDDNEGSSSD TAPLFQMAGD GKSTDDVTIP 750
    MLFLFSKEGN IILDAIREYQ QVEVLLSDKA KDRDLESESG EQKPVENDSQ 800
    KQALEDLFMT PEEIAELLIV HEEESPVSQP EVPSSDSPSG GDRTSERDIT 850
    PESQEHKTEE TEHSPKDNVQ TPPENSEDST EEKMDNKVQP MESILADWKE 900
    DIEAFEMMEK DEL 913
    Length:913
    Mass (Da):102,735
    Last modified:March 3, 2009 - v2
    Checksum:iBB7164FF7FA2BC83
    GO

    Sequence cautioni

    The sequence AAH72826.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072826 mRNA. Translation: AAH72826.1. Different initiation.
    RefSeqiNP_001085481.2. NM_001092012.1.
    UniGeneiXl.47665.

    Genome annotation databases

    GeneIDi443907.
    KEGGixla:443907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC072826 mRNA. Translation: AAH72826.1 . Different initiation.
    RefSeqi NP_001085481.2. NM_001092012.1.
    UniGenei Xl.47665.

    3D structure databases

    ProteinModelPortali Q6GQB9.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH47. Glycoside Hydrolase Family 47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443907.
    KEGGi xla:443907.

    Organism-specific databases

    CTDi 80267.
    Xenbasei XB-GENE-5811512. edem3.

    Phylogenomic databases

    HOVERGENi HBG107835.
    KOi K10086.

    Family and domain databases

    Gene3Di 1.50.10.50. 1 hit.
    InterProi IPR001382. Glyco_hydro_47.
    IPR003137. Protease-assoc_domain.
    [Graphical view ]
    PANTHERi PTHR11742. PTHR11742. 1 hit.
    Pfami PF01532. Glyco_hydro_47. 1 hit.
    PF02225. PA. 1 hit.
    [Graphical view ]
    PRINTSi PR00747. GLYHDRLASE47.
    SUPFAMi SSF48225. SSF48225. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiEDEM3_XENLA
    AccessioniPrimary (citable) accession number: Q6GQB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3