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Q6GQB9

- EDEM3_XENLA

UniProt

Q6GQB9 - EDEM3_XENLA

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Protein
ER degradation-enhancing alpha-mannosidase-like protein 3
Gene
edem3
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in endoplasmic reticulum-associated degradation (ERAD) By similarity.

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Proton donor By similarity
Active sitei279 – 2791 By similarity
Active sitei391 – 3911 By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Unfolded protein response

Protein family/group databases

CAZyiGH47. Glycoside Hydrolase Family 47.

Names & Taxonomyi

Protein namesi
Recommended name:
ER degradation-enhancing alpha-mannosidase-like protein 3 (EC:3.2.1.113)
Alternative name(s):
Alpha-1,2-mannosidase EDEM3
Gene namesi
Name:edem3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5811512. edem3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Chaini16 – 913898ER degradation-enhancing alpha-mannosidase-like protein 3
PRO_0000364227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi497 – 4971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi797 – 7971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6GQB9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini660 – 766107PA
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi910 – 9134Prevents secretion from ER Reviewed prediction

Domaini

Contains a protease-associated domain (PA) of unknown function (By similarity).

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107835.
KOiK10086.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
IPR003137. Protease-assoc_domain.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
PF02225. PA. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQB9-1 [UniParc]FASTAAdd to Basket

« Hide

MGCPAVEARR WGDMWLVVAF CLLGHGHAAV TKEEKAHLRS QVLEMFDHAY    50
GNYMQHAYPA DELMPLTCRG RIRGQEPSRG DVDDALGKFS LTLIDTLDTL 100
VVLNKTKEFE DAVRKVITDV NLDNDIVVSV FETNIRVLGG LLGGHSVAIM 150
LKENGDGMQW YNDELLHMAK ELGYKLLPAF NTTSGLPYPR INLKFGIRRP 200
EARTGTETDT CTACAGTMIL EFAALSRFTG ISVFEEHARK ALDFLWDKRQ 250
RSSNLVGVTI NIHTGDWVRK DSGVGAGIDS YYEYLLKAYV LLGDDSYLER 300
FNTHYDAIMR YISQPPLLLD VHIHKPMLTA RTWMDSLLAF FPGLQVLKGD 350
IRPAIETHEM LYQVIKKHNF LPEAFTTDFR VHWAQHPLRP EFAESTYFLY 400
KATGDPYYLE VGKTLIDNLN KYARVPCGFA AVKDVRTGSH EDRMDSFFLA 450
EMFKYLYLLF SEREDLIFDI EDYIFTTEAH LLPLSLSTAN PSSTKKNTTT 500
QYTELDDSNF DWSCPNTQIL FRNDPMYAQN IREPLKNVVD KNCPRSPSRL 550
DEISGSGKMP PLRARDFMAS NSEHLEILKK MGVSLIHLKD GRVQLVQHAN 600
QAASSIDAED GLRFMQEMIE LSSQQQKEQQ LPPRAVQIVS HPFYGRVVLT 650
AGPAQFGMDL SKHLAGAQGL VARAEPYSGC SDITNGQAIQ GKIALMQRGQ 700
CMFAEKARNV QKAGAIGGIV IDDNEGSSSD TAPLFQMAGD GKSTDDVTIP 750
MLFLFSKEGN IILDAIREYQ QVEVLLSDKA KDRDLESESG EQKPVENDSQ 800
KQALEDLFMT PEEIAELLIV HEEESPVSQP EVPSSDSPSG GDRTSERDIT 850
PESQEHKTEE TEHSPKDNVQ TPPENSEDST EEKMDNKVQP MESILADWKE 900
DIEAFEMMEK DEL 913
Length:913
Mass (Da):102,735
Last modified:March 3, 2009 - v2
Checksum:iBB7164FF7FA2BC83
GO

Sequence cautioni

The sequence AAH72826.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072826 mRNA. Translation: AAH72826.1. Different initiation.
RefSeqiNP_001085481.2. NM_001092012.1.
UniGeneiXl.47665.

Genome annotation databases

GeneIDi443907.
KEGGixla:443907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072826 mRNA. Translation: AAH72826.1 . Different initiation.
RefSeqi NP_001085481.2. NM_001092012.1.
UniGenei Xl.47665.

3D structure databases

ProteinModelPortali Q6GQB9.
ModBasei Search...

Protein family/group databases

CAZyi GH47. Glycoside Hydrolase Family 47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443907.
KEGGi xla:443907.

Organism-specific databases

CTDi 80267.
Xenbasei XB-GENE-5811512. edem3.

Phylogenomic databases

HOVERGENi HBG107835.
KOi K10086.

Family and domain databases

Gene3Di 1.50.10.50. 1 hit.
InterProi IPR001382. Glyco_hydro_47.
IPR003137. Protease-assoc_domain.
[Graphical view ]
PANTHERi PTHR11742. PTHR11742. 1 hit.
Pfami PF01532. Glyco_hydro_47. 1 hit.
PF02225. PA. 1 hit.
[Graphical view ]
PRINTSi PR00747. GLYHDRLASE47.
SUPFAMi SSF48225. SSF48225. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiEDEM3_XENLA
AccessioniPrimary (citable) accession number: Q6GQB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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