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Q6GQB9 (EDEM3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER degradation-enhancing alpha-mannosidase-like protein 3

EC=3.2.1.113
Alternative name(s):
Alpha-1,2-mannosidase EDEM3
Gene names
Name:edem3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length913 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in endoplasmic reticulum-associated degradation (ERAD) By similarity.

Catalytic activity

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Domain

Contains a protease-associated domain (PA) of unknown function By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Contains 1 PA (protease associated) domain.

Sequence caution

The sequence AAH72826.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processUnfolded protein response
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processresponse to unfolded protein

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 913898ER degradation-enhancing alpha-mannosidase-like protein 3
PRO_0000364227

Regions

Domain660 – 766107PA
Motif910 – 9134Prevents secretion from ER Potential

Sites

Active site1321Proton donor By similarity
Active site2791 By similarity
Active site3911 By similarity

Amino acid modifications

Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential
Glycosylation7971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6GQB9 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: BB7164FF7FA2BC83

FASTA913102,735
        10         20         30         40         50         60 
MGCPAVEARR WGDMWLVVAF CLLGHGHAAV TKEEKAHLRS QVLEMFDHAY GNYMQHAYPA 

        70         80         90        100        110        120 
DELMPLTCRG RIRGQEPSRG DVDDALGKFS LTLIDTLDTL VVLNKTKEFE DAVRKVITDV 

       130        140        150        160        170        180 
NLDNDIVVSV FETNIRVLGG LLGGHSVAIM LKENGDGMQW YNDELLHMAK ELGYKLLPAF 

       190        200        210        220        230        240 
NTTSGLPYPR INLKFGIRRP EARTGTETDT CTACAGTMIL EFAALSRFTG ISVFEEHARK 

       250        260        270        280        290        300 
ALDFLWDKRQ RSSNLVGVTI NIHTGDWVRK DSGVGAGIDS YYEYLLKAYV LLGDDSYLER 

       310        320        330        340        350        360 
FNTHYDAIMR YISQPPLLLD VHIHKPMLTA RTWMDSLLAF FPGLQVLKGD IRPAIETHEM 

       370        380        390        400        410        420 
LYQVIKKHNF LPEAFTTDFR VHWAQHPLRP EFAESTYFLY KATGDPYYLE VGKTLIDNLN 

       430        440        450        460        470        480 
KYARVPCGFA AVKDVRTGSH EDRMDSFFLA EMFKYLYLLF SEREDLIFDI EDYIFTTEAH 

       490        500        510        520        530        540 
LLPLSLSTAN PSSTKKNTTT QYTELDDSNF DWSCPNTQIL FRNDPMYAQN IREPLKNVVD 

       550        560        570        580        590        600 
KNCPRSPSRL DEISGSGKMP PLRARDFMAS NSEHLEILKK MGVSLIHLKD GRVQLVQHAN 

       610        620        630        640        650        660 
QAASSIDAED GLRFMQEMIE LSSQQQKEQQ LPPRAVQIVS HPFYGRVVLT AGPAQFGMDL 

       670        680        690        700        710        720 
SKHLAGAQGL VARAEPYSGC SDITNGQAIQ GKIALMQRGQ CMFAEKARNV QKAGAIGGIV 

       730        740        750        760        770        780 
IDDNEGSSSD TAPLFQMAGD GKSTDDVTIP MLFLFSKEGN IILDAIREYQ QVEVLLSDKA 

       790        800        810        820        830        840 
KDRDLESESG EQKPVENDSQ KQALEDLFMT PEEIAELLIV HEEESPVSQP EVPSSDSPSG 

       850        860        870        880        890        900 
GDRTSERDIT PESQEHKTEE TEHSPKDNVQ TPPENSEDST EEKMDNKVQP MESILADWKE 

       910 
DIEAFEMMEK DEL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC072826 mRNA. Translation: AAH72826.1. Different initiation.
RefSeqNP_001085481.2. NM_001092012.1.
UniGeneXl.47665.

3D structure databases

ProteinModelPortalQ6GQB9.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH47. Glycoside Hydrolase Family 47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443907.
KEGGxla:443907.

Organism-specific databases

CTD80267.
XenbaseXB-GENE-5811512. edem3.

Phylogenomic databases

HOVERGENHBG107835.
KOK10086.

Family and domain databases

Gene3D1.50.10.50. 1 hit.
InterProIPR001382. Glyco_hydro_47.
IPR003137. Protease-assoc_domain.
[Graphical view]
PANTHERPTHR11742. PTHR11742. 1 hit.
PfamPF01532. Glyco_hydro_47. 1 hit.
PF02225. PA. 1 hit.
[Graphical view]
PRINTSPR00747. GLYHDRLASE47.
SUPFAMSSF48225. SSF48225. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEDEM3_XENLA
AccessionPrimary (citable) accession number: Q6GQB9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries