ID Q6GQB4_XENLA Unreviewed; 916 AA. AC Q6GQB4; DT 19-JUL-2004, integrated into UniProtKB/TrEMBL. DT 19-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 105. DE RecName: Full=Hexokinase-1 {ECO:0000256|ARBA:ARBA00044081}; DE EC=2.7.1.1 {ECO:0000256|ARBA:ARBA00012324}; DE AltName: Full=Hexokinase type I {ECO:0000256|ARBA:ARBA00044308}; GN Name=hk1.L {ECO:0000313|RefSeq:NP_001096656.1, GN ECO:0000313|Xenbase:XB-GENE-944854}; GN Synonyms=Hexokinase {ECO:0000313|RefSeq:NP_001096656.1}, hk1 GN {ECO:0000313|RefSeq:NP_001096656.1, GN ECO:0000313|Xenbase:XB-GENE-944854}, hk1-A GN {ECO:0000313|EMBL:AAH72832.1, ECO:0000313|RefSeq:NP_001096656.1}; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH72832.1}; RN [1] {ECO:0000313|RefSeq:NP_001096656.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11091085; DOI=10.1016/S0925-4773(00)00469-X; RA Brewster R., Ruiz i Altaba A.; RT "Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS."; RL Mech. Dev. 99:159-162(2000). RN [2] {ECO:0000313|RefSeq:NP_001096656.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12454917; DOI=10.1002/dvdy.10174; RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W., RA Richardson P.; RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus RT initiative."; RL Dev. Dyn. 225:384-391(2002). RN [3] {ECO:0000313|EMBL:AAH72832.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAH72832.1}; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|RefSeq:NP_001096656.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+); CC Xref=Rhea:RHEA:10948, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:58723, ChEBI:CHEBI:58725, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00043797}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10949; CC Evidence={ECO:0000256|ARBA:ARBA00043797}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+); CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00000435}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826; CC Evidence={ECO:0000256|ARBA:ARBA00000435}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00000417}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741; CC Evidence={ECO:0000256|ARBA:ARBA00000417}; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+); CC Xref=Rhea:RHEA:11028, ChEBI:CHEBI:4208, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58735, ChEBI:CHEBI:456216; EC=2.7.1.1; CC Evidence={ECO:0000256|ARBA:ARBA00043834}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11029; CC Evidence={ECO:0000256|ARBA:ARBA00043834}; CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- CC phosphate and glycerone phosphate from D-glucose: step 1/4. CC {ECO:0000256|ARBA:ARBA00004888}. CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism. CC {ECO:0000256|ARBA:ARBA00005028}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol CC {ECO:0000256|ARBA:ARBA00004514}. Membrane CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion outer membrane CC {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004450}. CC -!- SIMILARITY: Belongs to the hexokinase family. CC {ECO:0000256|ARBA:ARBA00009225}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC072832; AAH72832.1; -; mRNA. DR RefSeq; NP_001096656.1; NM_001103186.1. DR STRING; 8355.Q6GQB4; -. DR PaxDb; 8355-Q6GQB4; -. DR GeneID; 394323; -. DR KEGG; xla:394323; -. DR AGR; Xenbase:XB-GENE-944854; -. DR CTD; 394323; -. DR Xenbase; XB-GENE-944854; hk1.L. DR OMA; DHAKVKM; -. DR OrthoDB; 5481886at2759; -. DR UniPathway; UPA00109; UER00180. DR UniPathway; UPA00242; -. DR Proteomes; UP000186698; Chromosome 7L. DR Bgee; 394323; Expressed in muscle tissue and 16 other cell types or tissues. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0005536; F:glucose binding; IEA:InterPro. DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-EC. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway. DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway. DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 2. DR Gene3D; 3.30.420.40; -; 2. DR Gene3D; 3.40.367.20; -; 2. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR001312; Hexokinase. DR InterPro; IPR019807; Hexokinase_BS. DR InterPro; IPR022673; Hexokinase_C. DR InterPro; IPR022672; Hexokinase_N. DR PANTHER; PTHR19443; HEXOKINASE; 1. DR PANTHER; PTHR19443:SF10; HEXOKINASE-1; 1. DR Pfam; PF00349; Hexokinase_1; 2. DR Pfam; PF03727; Hexokinase_2; 2. DR PRINTS; PR00475; HEXOKINASE. DR SUPFAM; SSF53067; Actin-like ATPase domain; 4. DR PROSITE; PS00378; HEXOKINASE_1; 2. DR PROSITE; PS51748; HEXOKINASE_2; 2. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Glycolysis {ECO:0000256|ARBA:ARBA00023152}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198}; KW Innate immunity {ECO:0000256|ARBA:ARBA00022588}; KW Kinase {ECO:0000256|ARBA:ARBA00022777}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000186698}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 22..218 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 226..459 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" FT DOMAIN 470..667 FT /note="Hexokinase N-terminal" FT /evidence="ECO:0000259|Pfam:PF00349" FT DOMAIN 673..907 FT /note="Hexokinase C-terminal" FT /evidence="ECO:0000259|Pfam:PF03727" SQ SEQUENCE 916 AA; 102449 MW; 9F62CC50B0E4735B CRC64; MIAAQLLAYY FTELKDDQLK KIDKYLYAMR LSDETLLDIT GRFRAEMANG LSRDTNPTAI IKMLPTFVRS IPDGTEKGDF IALDLGGSNF RILRVKVSHE KKQTVQMESE IYDTPEDIIH GSGTRLFDHV AECLGDFMQK KQIKDKKLPV GFTFSFPCIQ TKIDEGVLVT WTKRFKASGV EGMDVVKLLN RAIKKRGDYE ADIMAVVNDT VGTMMTCGFD DQRCEVGIII GTGTNACYME ELRHIDMVEG DEGRMCINTE WGAFGDEGCL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM YMGELVRLIL VKMAKEGLLF EGRITPELLT RGKFETKHIS AIEKSKEGLS KAKDILTRLG VEPSHEDCIA VQHVCTIVSF RSANLVAATL GGILIRLRDN KGVPRLRTTV GIDGSLYKMH PQYARRLHKT VRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLSEQRRQI DETLEEFKLS REQLLEVKRR MRIEMENGLR KKTHESAKVK MLATFVRSTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKR RTVEMHNKIY AIPTDVMQGT GEELFDHIVH CISDFLDYMG IKGARLPLGF TFSFPCKQTS LDAGILVTWT KGFKSTDCEG EDVVNLLREG IKRREEFDLD VVAIVNDTVG TMMTCAYEDP NCEIGLIVGT GSNACYMEET KNIEMVDGEQ GRMCVNMEWG AFGDNGCLDD IRTVYDKAVD ELSLNSGKQR YEKMISGMYL GEIVRNILID FTKRGFLFRG QISEALKTTS IFETKFLSQI ESDRLALLQV RSILQQLGLN STCDDSIIVK EVCGAVSRRA AQLCGAGMAA VVDKIRENRG LDHLDVTVGV DGTLYKLHPH FSKIMHQTVK DLAPKCNVSF LLSEDGSGKG AALITAVACR LRTEQN //