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Protein

Hexokinase

Gene

hk1

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:hk1Imported
Synonyms:hk1-AImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-944854. hk1.

Structurei

3D structure databases

ProteinModelPortaliQ6GQB4.
SMRiQ6GQB4. Positions 16-914.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG005020.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GQB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAQLLAYY FTELKDDQLK KIDKYLYAMR LSDETLLDIT GRFRAEMANG
60 70 80 90 100
LSRDTNPTAI IKMLPTFVRS IPDGTEKGDF IALDLGGSNF RILRVKVSHE
110 120 130 140 150
KKQTVQMESE IYDTPEDIIH GSGTRLFDHV AECLGDFMQK KQIKDKKLPV
160 170 180 190 200
GFTFSFPCIQ TKIDEGVLVT WTKRFKASGV EGMDVVKLLN RAIKKRGDYE
210 220 230 240 250
ADIMAVVNDT VGTMMTCGFD DQRCEVGIII GTGTNACYME ELRHIDMVEG
260 270 280 290 300
DEGRMCINTE WGAFGDEGCL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM
310 320 330 340 350
YMGELVRLIL VKMAKEGLLF EGRITPELLT RGKFETKHIS AIEKSKEGLS
360 370 380 390 400
KAKDILTRLG VEPSHEDCIA VQHVCTIVSF RSANLVAATL GGILIRLRDN
410 420 430 440 450
KGVPRLRTTV GIDGSLYKMH PQYARRLHKT VRRLVPDSDV RFLLSESGSG
460 470 480 490 500
KGAAMVTAVA YRLSEQRRQI DETLEEFKLS REQLLEVKRR MRIEMENGLR
510 520 530 540 550
KKTHESAKVK MLATFVRSTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKR
560 570 580 590 600
RTVEMHNKIY AIPTDVMQGT GEELFDHIVH CISDFLDYMG IKGARLPLGF
610 620 630 640 650
TFSFPCKQTS LDAGILVTWT KGFKSTDCEG EDVVNLLREG IKRREEFDLD
660 670 680 690 700
VVAIVNDTVG TMMTCAYEDP NCEIGLIVGT GSNACYMEET KNIEMVDGEQ
710 720 730 740 750
GRMCVNMEWG AFGDNGCLDD IRTVYDKAVD ELSLNSGKQR YEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKRGFLFRG QISEALKTTS IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RSILQQLGLN STCDDSIIVK EVCGAVSRRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LDHLDVTVGV DGTLYKLHPH FSKIMHQTVK DLAPKCNVSF LLSEDGSGKG
910
AALITAVACR LRTEQN
Length:916
Mass (Da):102,449
Last modified:July 19, 2004 - v1
Checksum:i9F62CC50B0E4735B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072832 mRNA. Translation: AAH72832.1.
RefSeqiNP_001096656.1. NM_001103186.1.
UniGeneiXl.726.

Genome annotation databases

GeneIDi394323.
KEGGixla:394323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072832 mRNA. Translation: AAH72832.1.
RefSeqiNP_001096656.1. NM_001103186.1.
UniGeneiXl.726.

3D structure databases

ProteinModelPortaliQ6GQB4.
SMRiQ6GQB4. Positions 16-914.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi394323.
KEGGixla:394323.

Organism-specific databases

CTDi3098.
XenbaseiXB-GENE-944854. hk1.

Phylogenomic databases

HOVERGENiHBG005020.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiQ6GQB4_XENLA
AccessioniPrimary (citable) accession number: Q6GQB4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 22, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.