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Q6GQ23

- EOGT_XENLA

UniProt

Q6GQ23 - EOGT_XENLA

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Protein
EGF domain-specific O-linked N-acetylglucosamine transferase
Gene
eogt, aer61
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine.
UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.

GO - Molecular functioni

  1. protein N-acetylglucosaminyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. protein O-linked glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT61. Glycosyltransferase Family 61.

Names & Taxonomyi

Protein namesi
Recommended name:
EGF domain-specific O-linked N-acetylglucosamine transferase (EC:2.4.1.255)
Alternative name(s):
Extracellular O-linked N-acetylglucosamine transferase
Gene namesi
Name:eogt
Synonyms:aer61
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-994622. eogt.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 525501EGF domain-specific O-linked N-acetylglucosamine transferase
PRO_0000301976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi352 – 3521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi293 – 2953Required for optimal activity By similarity
Motifi522 – 5254Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG056678.
KOiK18134.

Family and domain databases

InterProiIPR007657. Glycosyltransferase_AER61.
[Graphical view]
PfamiPF04577. DUF563. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GQ23-1 [UniParc]FASTAAdd to Basket

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MVPLRLVLLL HIIHFSCENE VGSAANNGSA QLYNYRKIHL PDDHIPYYLH    50
SNRHVAALCL QDLHCPYKQH LQNLNSCWGY EKTCAEGHRF GYPVCDQVDF 100
GWAKTIEESQ QVFWRQADFG YVKERLAETQ ILCRPQEQGD SMLACSQNLQ 150
HCRATNLYLD LRHPRRGQEN FKEDFLQEGE IGGHCDLDKQ ALLSQGAWKS 200
PLQSWFAELQ SYSSFKFKPI EDAHCDIIIE KPTYFMKLDA GVNMYHHFCD 250
FVNLYITQHV NNSFSTDINI VMWTTSVYGY GDLFSDTWKA FTDYEITHLK 300
AYDNKRVCFK DAVFALLPRM RYGLFYNTPL ISHCHGSGLF RAFSQHVLHR 350
LNITQHPATE AKIRVTILVR STEFRKILNL DELVQALEAV PTFQVKVVDY 400
KYRVLGFLEQ LSITHNSDIF IGMHGAGLTH LLFLPDWAVV FELYNCEDAR 450
CYLDLARLRG IQYMTWEKGD KVFPQDKGHH PNLGEHPKFT NYAFDVEEFL 500
RLVQQGATYV SRHSKWPLRR TRDEL 525
Length:525
Mass (Da):61,182
Last modified:July 19, 2004 - v1
Checksum:i71165EA2755AA496
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072925 mRNA. Translation: AAH72925.1.
RefSeqiNP_001085557.1. NM_001092088.1.
UniGeneiXl.7160.

Genome annotation databases

GeneIDi443983.
KEGGixla:443983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC072925 mRNA. Translation: AAH72925.1 .
RefSeqi NP_001085557.1. NM_001092088.1.
UniGenei Xl.7160.

3D structure databases

ModBasei Search...

Protein family/group databases

CAZyi GT61. Glycosyltransferase Family 61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443983.
KEGGi xla:443983.

Organism-specific databases

CTDi 285203.
Xenbasei XB-GENE-994622. eogt.

Phylogenomic databases

HOVERGENi HBG056678.
KOi K18134.

Family and domain databases

InterProi IPR007657. Glycosyltransferase_AER61.
[Graphical view ]
Pfami PF04577. DUF563. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.

Entry informationi

Entry nameiEOGT_XENLA
AccessioniPrimary (citable) accession number: Q6GQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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