Reviewed,
UniProtKB/Swiss-Prot Q6GPI1 (CTRB2_HUMAN)
Last modified
June 16, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Chymotrypsinogen B2 EC=3.4.21.1 Cleaved into the following 3 chains: 1- Recommended name: Chymotrypsin B2 chain A 2- Recommended name: Chymotrypsin B2 chain B 3- Recommended name: Chymotrypsin B2 chain C | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 263 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Digestion |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Disulfide bond Zymogen |
| Gene Ontology (GO) | |
| Biological process | digestion Inferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | By similarity | ||||||||
| Chain | 19 – 263 | 245 | Chymotrypsinogen B2 | PRO_0000285870 | |||||||
| Chain | 19 – 31 | 13 | Chymotrypsin B2 chain A | PRO_0000285871 | |||||||
| Chain | 34 – 164 | 131 | Chymotrypsin B2 chain B | PRO_0000285872 | |||||||
| Chain | 167 – 263 | 97 | Chymotrypsin B2 chain C | PRO_0000285873 | |||||||
Regions | |||||||||||
| Domain | 34 – 261 | 228 | Peptidase S1 | ||||||||
Sites | |||||||||||
| Active site | 75 | 1 | Charge relay system By similarity | ||||||||
| Active site | 120 | 1 | Charge relay system By similarity | ||||||||
| Active site | 213 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 19 ↔ 140 | By similarity | |||||||||
| Disulfide bond | 60 ↔ 76 | By similarity | |||||||||
| Disulfide bond | 154 ↔ 219 | By similarity | |||||||||
| Disulfide bond | 186 ↔ 200 | By similarity | |||||||||
| Disulfide bond | 209 ↔ 238 | By similarity | |||||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas. |
Cross-references
Sequence databases | |
|---|---|
| BC073145 mRNA. Translation: AAH73145.1. | |
| IPI | IPI00742763. |
| UniGene | Hs.632211 |
3D structure databases | |
| SMR | Q6GPI1. Positions 19-263. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S01.152. |
PTM databases | |
| PhosphoSite | Q6GPI1. |
Proteomic databases | |
| PRIDE | Q6GPI1. |
Genome annotation databases | |
| Ensembl | ENSG00000168925. Homo sapiens. [Contig view] |
Organism-specific databases | |
| GeneCards | GC16M073796. |
| HGNC | HGNC:2522. CTRB2. |
| PharmGKB | PA27023. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q6GPI1. |
Enzyme and pathway databases | |
| BRENDA | 3.4.21.1. 247. |
Gene expression databases | |
| CleanEx | HS_CTRB2. |
Family and domain databases | |
| InterPro | IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001314. Peptidase_S1A. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR00722. CHYMOTRYPSIN. |
| SMART | SM00020. Tryp_SPc. 1 hit. [Graphical view] |
| PROSITE | PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CTRB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6GPI1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

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