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Q6GPH4

- XAF1_HUMAN

UniProt

Q6GPH4 - XAF1_HUMAN

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Protein

XIAP-associated factor 1

Gene
XAF1, BIRC4BP, XIAPAF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 9978TRAF-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cytokine-mediated signaling pathway Source: Reactome
  3. negative regulation of protein complex assembly Source: Ensembl
  4. response to interferon-beta Source: BHF-UCL
  5. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_25162. Interferon alpha/beta signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
XIAP-associated factor 1
Alternative name(s):
BIRC4-binding protein
Gene namesi
Name:XAF1
Synonyms:BIRC4BP, XIAPAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:30932. XAF1.

Subcellular locationi

Cytoplasm. Nucleus. Mitochondrion
Note: Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.3 Publications
Isoform 1 : Nucleus 3 Publications
Isoform 5 : Nucleus 3 Publications

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. mitochondrion Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA162409299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301XIAP-associated factor 1PRO_0000329028Add
BLAST

Proteomic databases

MaxQBiQ6GPH4.
PaxDbiQ6GPH4.
PRIDEiQ6GPH4.

Expressioni

Tissue specificityi

Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).4 Publications

Developmental stagei

Selectively expressed in third trimester placenta.1 Publication

Inductioni

Up-regulated by IFNB1/IFN-beta in cell lines sensitive to the proapoptotic effects of IFNB1 but not in apoptosis-resistant cells. Up-regulated by TNF in trophoblast cells.2 Publications

Gene expression databases

ArrayExpressiQ6GPH4.
BgeeiQ6GPH4.
CleanExiHS_XAF1.
GenevestigatoriQ6GPH4.

Organism-specific databases

HPAiHPA057302.

Interactioni

Subunit structurei

Interacts with BIRC4; the interaction is not detected in (1 Publication). Interacts with BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation. Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.4 Publications

Protein-protein interaction databases

BioGridi120121. 8 interactions.
IntActiQ6GPH4. 2 interactions.
MINTiMINT-216123.
STRINGi9606.ENSP00000354822.

Structurei

Secondary structure

1
301
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni261 – 2633
Beta strandi264 – 2663
Turni268 – 2703
Helixi279 – 29214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LXWNMR-A251-301[»]
ProteinModelPortaliQ6GPH4.
SMRiQ6GPH4. Positions 74-134, 251-301.

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 9978TRAF-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG87143.
HOVERGENiHBG108681.
OrthoDBiEOG73806B.
PhylomeDBiQ6GPH4.
TreeFamiTF331416.

Family and domain databases

InterProiIPR001293. Znf_TRAF.
[Graphical view]
PROSITEiPS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6GPH4-1) [UniParc]FASTAAdd to Basket

Also known as: XAF1(A)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC    50
KLEHQQVGCT MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL 100
HESYCGSRTE LCQGCGQFIM HRMLAQHRDV CRSEQAQLGK GERISAPERE 150
IYCHYCNQMI PENKYFHHMG KCCPDSEFKK HFPVGNPEIL PSSLPSQAAE 200
NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD PLLMSEPKPR 250
TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF 300
S 301
Length:301
Mass (Da):34,626
Last modified:July 19, 2004 - v1
Checksum:iFC9D48BD07BE541D
GO
Isoform 2 (identifier: Q6GPH4-2) [UniParc]FASTAAdd to Basket

Also known as: XAF1B

The sequence of this isoform differs from the canonical sequence as follows:
     57-75: Missing.

Show »
Length:282
Mass (Da):32,471
Checksum:i6EAC4F7EC6F8E64A
GO
Isoform 3 (identifier: Q6GPH4-3) [UniParc]FASTAAdd to Basket

Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     142-301: Missing.

Show »
Length:141
Mass (Da):16,322
Checksum:iB286A33BC34A10A2
GO
Isoform 4 (identifier: Q6GPH4-4) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     57-75: Missing.
     142-301: Missing.

Show »
Length:122
Mass (Da):14,167
Checksum:i36CC8B71B4DCCD8A
GO
Isoform 5 (identifier: Q6GPH4-5) [UniParc]FASTAAdd to Basket

Also known as: XAF1C

The sequence of this isoform differs from the canonical sequence as follows:
     141-301: GERISAPERE...SKGKQVRNFS → ETSPDPGKCLSITVAAALSAHLWPFT

Show »
Length:166
Mass (Da):18,960
Checksum:i0EDD81DA26C30B50
GO
Isoform 6 (identifier: Q6GPH4-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     103-140: SYCGSRTELC...CRSEQAQLGK → MSLHYGCCCP...ACVVKDAGSA

Show »
Length:199
Mass (Da):22,507
Checksum:iFCA89ECA5FB0ED46
GO
Isoform 7 (identifier: Q6GPH4-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-74: VGCTMCQQSMQKSSLEFH → GKEFQLLKGKSTVIIATK

Note: No experimental confirmation available.

Show »
Length:301
Mass (Da):34,543
Checksum:i556947EBEFD6B84E
GO

Sequence cautioni

The sequence CAA68030.1 differs from that shown. Reason: Frameshift at position 294.
The sequence AAH32776.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851E → G.
Corresponds to variant rs34195599 [ dbSNP | Ensembl ].
VAR_042616
Natural varianti132 – 1321R → H.
Corresponds to variant rs2271232 [ dbSNP | Ensembl ].
VAR_042617
Natural varianti188 – 1881E → K.
Corresponds to variant rs34625877 [ dbSNP | Ensembl ].
VAR_042618
Natural varianti219 – 2191R → I.
Corresponds to variant rs3736433 [ dbSNP | Ensembl ].
VAR_042619

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 6. VSP_032918Add
BLAST
Alternative sequencei57 – 7519Missing in isoform 2 and isoform 4. VSP_032919Add
BLAST
Alternative sequencei57 – 7418VGCTM…SLEFH → GKEFQLLKGKSTVIIATK in isoform 7. VSP_032920Add
BLAST
Alternative sequencei103 – 14038SYCGS…AQLGK → MSLHYGCCCPECTSVAIKEM MWVIRPRVACVVKDAGSA in isoform 6. VSP_032921Add
BLAST
Alternative sequencei141 – 301161GERIS…VRNFS → ETSPDPGKCLSITVAAALSA HLWPFT in isoform 5. VSP_032922Add
BLAST
Alternative sequencei142 – 301160Missing in isoform 3 and isoform 4. VSP_032923Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321R → Q in BAF85537. 1 Publication
Sequence conflicti138 – 1381L → R in BAF85537. 1 Publication
Sequence conflicti196 – 1961S → R in BAF85537. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99699 mRNA. Translation: CAA68030.1. Frameshift.
EF028165 mRNA. Translation: ABM74556.1.
EF028166 mRNA. Translation: ABM74557.1.
AK290276 mRNA. Translation: BAF82965.1.
AK292710 mRNA. Translation: BAF85399.1.
AK292848 mRNA. Translation: BAF85537.1.
CH471108 Genomic DNA. Translation: EAW90288.1.
CH471108 Genomic DNA. Translation: EAW90289.1.
BC032776 mRNA. Translation: AAH32776.1. Different initiation.
BC073156 mRNA. Translation: AAH73156.1.
BX649188 mRNA. Translation: CAE46206.1.
CCDSiCCDS11080.1. [Q6GPH4-1]
CCDS11081.1. [Q6GPH4-2]
RefSeqiNP_059993.2. NM_017523.3. [Q6GPH4-1]
NP_954590.1. NM_199139.2. [Q6GPH4-2]
XP_005256765.1. XM_005256708.1. [Q6GPH4-6]
UniGeneiHs.441975.

Genome annotation databases

EnsembliENST00000346752; ENSP00000341029; ENSG00000132530. [Q6GPH4-2]
ENST00000361842; ENSP00000354822; ENSG00000132530. [Q6GPH4-1]
ENST00000571673; ENSP00000461196; ENSG00000132530. [Q6GPH4-4]
ENST00000574962; ENSP00000458229; ENSG00000132530. [Q6GPH4-3]
GeneIDi54739.
KEGGihsa:54739.
UCSCiuc002gdm.1. human. [Q6GPH4-1]
uc002gdo.3. human. [Q6GPH4-2]
uc002gdp.4. human. [Q6GPH4-6]

Polymorphism databases

DMDMi74736479.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99699 mRNA. Translation: CAA68030.1 . Frameshift.
EF028165 mRNA. Translation: ABM74556.1 .
EF028166 mRNA. Translation: ABM74557.1 .
AK290276 mRNA. Translation: BAF82965.1 .
AK292710 mRNA. Translation: BAF85399.1 .
AK292848 mRNA. Translation: BAF85537.1 .
CH471108 Genomic DNA. Translation: EAW90288.1 .
CH471108 Genomic DNA. Translation: EAW90289.1 .
BC032776 mRNA. Translation: AAH32776.1 . Different initiation.
BC073156 mRNA. Translation: AAH73156.1 .
BX649188 mRNA. Translation: CAE46206.1 .
CCDSi CCDS11080.1. [Q6GPH4-1 ]
CCDS11081.1. [Q6GPH4-2 ]
RefSeqi NP_059993.2. NM_017523.3. [Q6GPH4-1 ]
NP_954590.1. NM_199139.2. [Q6GPH4-2 ]
XP_005256765.1. XM_005256708.1. [Q6GPH4-6 ]
UniGenei Hs.441975.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LXW NMR - A 251-301 [» ]
ProteinModelPortali Q6GPH4.
SMRi Q6GPH4. Positions 74-134, 251-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120121. 8 interactions.
IntActi Q6GPH4. 2 interactions.
MINTi MINT-216123.
STRINGi 9606.ENSP00000354822.

Polymorphism databases

DMDMi 74736479.

Proteomic databases

MaxQBi Q6GPH4.
PaxDbi Q6GPH4.
PRIDEi Q6GPH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346752 ; ENSP00000341029 ; ENSG00000132530 . [Q6GPH4-2 ]
ENST00000361842 ; ENSP00000354822 ; ENSG00000132530 . [Q6GPH4-1 ]
ENST00000571673 ; ENSP00000461196 ; ENSG00000132530 . [Q6GPH4-4 ]
ENST00000574962 ; ENSP00000458229 ; ENSG00000132530 . [Q6GPH4-3 ]
GeneIDi 54739.
KEGGi hsa:54739.
UCSCi uc002gdm.1. human. [Q6GPH4-1 ]
uc002gdo.3. human. [Q6GPH4-2 ]
uc002gdp.4. human. [Q6GPH4-6 ]

Organism-specific databases

CTDi 54739.
GeneCardsi GC17P006659.
HGNCi HGNC:30932. XAF1.
HPAi HPA057302.
MIMi 606717. gene.
neXtProti NX_Q6GPH4.
PharmGKBi PA162409299.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87143.
HOVERGENi HBG108681.
OrthoDBi EOG73806B.
PhylomeDBi Q6GPH4.
TreeFami TF331416.

Enzyme and pathway databases

Reactomei REACT_25162. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSi XAF1. human.
GeneWikii XAF1.
GenomeRNAii 54739.
NextBioi 57333.
PROi Q6GPH4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6GPH4.
Bgeei Q6GPH4.
CleanExi HS_XAF1.
Genevestigatori Q6GPH4.

Family and domain databases

InterProi IPR001293. Znf_TRAF.
[Graphical view ]
PROSITEi PS50145. ZF_TRAF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH BIRC4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses."
    Chung S.K., Lee M.G., Ryu B.K., Lee J.H., Han J., Byun D.S., Chae K.S., Lee K.Y., Jang J.Y., Kim H.J., Chi S.G.
    Gastroenterology 132:2459-2477(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6).
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-57.
    Tissue: Endometrium.
  7. "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis."
    Leaman D.W., Chawla-Sarkar M., Vyas K., Reheman M., Tamai K., Toji S., Borden E.C.
    J. Biol. Chem. 277:28504-28511(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  8. "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1."
    Yin W., Cheepala S., Clifford J.L.
    Biochem. Biophys. Res. Commun. 339:1148-1154(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP."
    Xia Y., Novak R., Lewis J., Duckett C.S., Phillips A.C.
    Mol. Cell. Biochem. 286:67-76(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN TNF-ALPHA-INDUCED APOPTOSIS, NEGATIVE INTERACTION WITH BIRC4.
  10. "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex."
    Arora V., Cheung H.H., Plenchette S., Micali O.C., Liston P., Korneluk R.G.
    J. Biol. Chem. 282:26202-26209(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN BIRC5 DEGRADATION, INTERACTION WITH BIRC1; BIRC2; BIRC3; BIRC4; BIRC7 AND BIRC8.
  11. "XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway."
    Straszewski-Chavez S.L., Visintin I.P., Karassina N., Los G., Liston P., Halaban R., Fadiel A., Mor G.
    J. Biol. Chem. 282:13059-13072(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN TNF-ALPHA-INDUCED APOPTOSIS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
  12. "ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)."
    Han J., Kim Y.L., Lee K.W., Her N.G., Ha T.K., Yoon S., Jeong S.I., Lee J.H., Kang M.J., Lee M.G., Ryu B.K., Baik J.H., Chi S.G.
    Cell Death Differ. 20:1055-1067(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF114.

Entry informationi

Entry nameiXAF1_HUMAN
AccessioniPrimary (citable) accession number: Q6GPH4
Secondary accession number(s): A2T931
, A2T932, A8K2L1, A8K9Y3, D3DTM6, Q6MZE8, Q8N557, Q99982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi