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Q6GPH4

- XAF1_HUMAN

UniProt

Q6GPH4 - XAF1_HUMAN

Protein

XIAP-associated factor 1

Gene

XAF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.5 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri22 – 9978TRAF-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cytokine-mediated signaling pathway Source: Reactome
    3. negative regulation of protein complex assembly Source: Ensembl
    4. response to interferon-beta Source: BHF-UCL
    5. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_25162. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    XIAP-associated factor 1
    Alternative name(s):
    BIRC4-binding protein
    Gene namesi
    Name:XAF1
    Synonyms:BIRC4BP, XIAPAF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30932. XAF1.

    Subcellular locationi

    Cytoplasm. Nucleus. Mitochondrion
    Note: Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. mitochondrion Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA162409299.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301XIAP-associated factor 1PRO_0000329028Add
    BLAST

    Proteomic databases

    MaxQBiQ6GPH4.
    PaxDbiQ6GPH4.
    PRIDEiQ6GPH4.

    Expressioni

    Tissue specificityi

    Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).4 Publications

    Developmental stagei

    Selectively expressed in third trimester placenta.1 Publication

    Inductioni

    Up-regulated by IFNB1/IFN-beta in cell lines sensitive to the proapoptotic effects of IFNB1 but not in apoptosis-resistant cells. Up-regulated by TNF in trophoblast cells.2 Publications

    Gene expression databases

    ArrayExpressiQ6GPH4.
    BgeeiQ6GPH4.
    CleanExiHS_XAF1.
    GenevestigatoriQ6GPH4.

    Organism-specific databases

    HPAiHPA057302.

    Interactioni

    Subunit structurei

    Interacts with BIRC4; the interaction is not detected in (PubMed:16432762). Interacts with BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation. Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.4 Publications

    Protein-protein interaction databases

    BioGridi120121. 8 interactions.
    IntActiQ6GPH4. 2 interactions.
    MINTiMINT-216123.
    STRINGi9606.ENSP00000354822.

    Structurei

    Secondary structure

    1
    301
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni261 – 2633
    Beta strandi264 – 2663
    Turni268 – 2703
    Helixi279 – 29214

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LXWNMR-A251-301[»]
    ProteinModelPortaliQ6GPH4.
    SMRiQ6GPH4. Positions 74-134, 251-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri22 – 9978TRAF-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG87143.
    HOVERGENiHBG108681.
    OrthoDBiEOG73806B.
    PhylomeDBiQ6GPH4.
    TreeFamiTF331416.

    Family and domain databases

    InterProiIPR001293. Znf_TRAF.
    [Graphical view]
    PROSITEiPS50145. ZF_TRAF. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6GPH4-1) [UniParc]FASTAAdd to Basket

    Also known as: XAF1(A)

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC    50
    KLEHQQVGCT MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL 100
    HESYCGSRTE LCQGCGQFIM HRMLAQHRDV CRSEQAQLGK GERISAPERE 150
    IYCHYCNQMI PENKYFHHMG KCCPDSEFKK HFPVGNPEIL PSSLPSQAAE 200
    NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD PLLMSEPKPR 250
    TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF 300
    S 301
    Length:301
    Mass (Da):34,626
    Last modified:July 19, 2004 - v1
    Checksum:iFC9D48BD07BE541D
    GO
    Isoform 2 (identifier: Q6GPH4-2) [UniParc]FASTAAdd to Basket

    Also known as: XAF1B

    The sequence of this isoform differs from the canonical sequence as follows:
         57-75: Missing.

    Show »
    Length:282
    Mass (Da):32,471
    Checksum:i6EAC4F7EC6F8E64A
    GO
    Isoform 3 (identifier: Q6GPH4-3) [UniParc]FASTAAdd to Basket

    Also known as: D

    The sequence of this isoform differs from the canonical sequence as follows:
         142-301: Missing.

    Show »
    Length:141
    Mass (Da):16,322
    Checksum:iB286A33BC34A10A2
    GO
    Isoform 4 (identifier: Q6GPH4-4) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         57-75: Missing.
         142-301: Missing.

    Show »
    Length:122
    Mass (Da):14,167
    Checksum:i36CC8B71B4DCCD8A
    GO
    Isoform 5 (identifier: Q6GPH4-5) [UniParc]FASTAAdd to Basket

    Also known as: XAF1C

    The sequence of this isoform differs from the canonical sequence as follows:
         141-301: GERISAPERE...SKGKQVRNFS → ETSPDPGKCLSITVAAALSAHLWPFT

    Show »
    Length:166
    Mass (Da):18,960
    Checksum:i0EDD81DA26C30B50
    GO
    Isoform 6 (identifier: Q6GPH4-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-102: Missing.
         103-140: SYCGSRTELC...CRSEQAQLGK → MSLHYGCCCP...ACVVKDAGSA

    Show »
    Length:199
    Mass (Da):22,507
    Checksum:iFCA89ECA5FB0ED46
    GO
    Isoform 7 (identifier: Q6GPH4-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-74: VGCTMCQQSMQKSSLEFH → GKEFQLLKGKSTVIIATK

    Note: No experimental confirmation available.

    Show »
    Length:301
    Mass (Da):34,543
    Checksum:i556947EBEFD6B84E
    GO

    Sequence cautioni

    The sequence CAA68030.1 differs from that shown. Reason: Frameshift at position 294.
    The sequence AAH32776.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321R → Q in BAF85537. (PubMed:14702039)Curated
    Sequence conflicti138 – 1381L → R in BAF85537. (PubMed:14702039)Curated
    Sequence conflicti196 – 1961S → R in BAF85537. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851E → G.
    Corresponds to variant rs34195599 [ dbSNP | Ensembl ].
    VAR_042616
    Natural varianti132 – 1321R → H.
    Corresponds to variant rs2271232 [ dbSNP | Ensembl ].
    VAR_042617
    Natural varianti188 – 1881E → K.
    Corresponds to variant rs34625877 [ dbSNP | Ensembl ].
    VAR_042618
    Natural varianti219 – 2191R → I.
    Corresponds to variant rs3736433 [ dbSNP | Ensembl ].
    VAR_042619

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 102102Missing in isoform 6. 1 PublicationVSP_032918Add
    BLAST
    Alternative sequencei57 – 7519Missing in isoform 2 and isoform 4. 2 PublicationsVSP_032919Add
    BLAST
    Alternative sequencei57 – 7418VGCTM…SLEFH → GKEFQLLKGKSTVIIATK in isoform 7. 1 PublicationVSP_032920Add
    BLAST
    Alternative sequencei103 – 14038SYCGS…AQLGK → MSLHYGCCCPECTSVAIKEM MWVIRPRVACVVKDAGSA in isoform 6. 1 PublicationVSP_032921Add
    BLAST
    Alternative sequencei141 – 301161GERIS…VRNFS → ETSPDPGKCLSITVAAALSA HLWPFT in isoform 5. CuratedVSP_032922Add
    BLAST
    Alternative sequencei142 – 301160Missing in isoform 3 and isoform 4. 1 PublicationVSP_032923Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99699 mRNA. Translation: CAA68030.1. Frameshift.
    EF028165 mRNA. Translation: ABM74556.1.
    EF028166 mRNA. Translation: ABM74557.1.
    AK290276 mRNA. Translation: BAF82965.1.
    AK292710 mRNA. Translation: BAF85399.1.
    AK292848 mRNA. Translation: BAF85537.1.
    CH471108 Genomic DNA. Translation: EAW90288.1.
    CH471108 Genomic DNA. Translation: EAW90289.1.
    BC032776 mRNA. Translation: AAH32776.1. Different initiation.
    BC073156 mRNA. Translation: AAH73156.1.
    BX649188 mRNA. Translation: CAE46206.1.
    CCDSiCCDS11080.1. [Q6GPH4-1]
    CCDS11081.1. [Q6GPH4-2]
    RefSeqiNP_059993.2. NM_017523.3. [Q6GPH4-1]
    NP_954590.1. NM_199139.2. [Q6GPH4-2]
    XP_005256765.1. XM_005256708.1. [Q6GPH4-6]
    UniGeneiHs.441975.

    Genome annotation databases

    EnsembliENST00000346752; ENSP00000341029; ENSG00000132530. [Q6GPH4-2]
    ENST00000361842; ENSP00000354822; ENSG00000132530. [Q6GPH4-1]
    ENST00000571673; ENSP00000461196; ENSG00000132530. [Q6GPH4-4]
    ENST00000574962; ENSP00000458229; ENSG00000132530. [Q6GPH4-3]
    GeneIDi54739.
    KEGGihsa:54739.
    UCSCiuc002gdm.1. human. [Q6GPH4-1]
    uc002gdo.3. human. [Q6GPH4-2]
    uc002gdp.4. human. [Q6GPH4-6]

    Polymorphism databases

    DMDMi74736479.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99699 mRNA. Translation: CAA68030.1 . Frameshift.
    EF028165 mRNA. Translation: ABM74556.1 .
    EF028166 mRNA. Translation: ABM74557.1 .
    AK290276 mRNA. Translation: BAF82965.1 .
    AK292710 mRNA. Translation: BAF85399.1 .
    AK292848 mRNA. Translation: BAF85537.1 .
    CH471108 Genomic DNA. Translation: EAW90288.1 .
    CH471108 Genomic DNA. Translation: EAW90289.1 .
    BC032776 mRNA. Translation: AAH32776.1 . Different initiation.
    BC073156 mRNA. Translation: AAH73156.1 .
    BX649188 mRNA. Translation: CAE46206.1 .
    CCDSi CCDS11080.1. [Q6GPH4-1 ]
    CCDS11081.1. [Q6GPH4-2 ]
    RefSeqi NP_059993.2. NM_017523.3. [Q6GPH4-1 ]
    NP_954590.1. NM_199139.2. [Q6GPH4-2 ]
    XP_005256765.1. XM_005256708.1. [Q6GPH4-6 ]
    UniGenei Hs.441975.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LXW NMR - A 251-301 [» ]
    ProteinModelPortali Q6GPH4.
    SMRi Q6GPH4. Positions 74-134, 251-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120121. 8 interactions.
    IntActi Q6GPH4. 2 interactions.
    MINTi MINT-216123.
    STRINGi 9606.ENSP00000354822.

    Polymorphism databases

    DMDMi 74736479.

    Proteomic databases

    MaxQBi Q6GPH4.
    PaxDbi Q6GPH4.
    PRIDEi Q6GPH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000346752 ; ENSP00000341029 ; ENSG00000132530 . [Q6GPH4-2 ]
    ENST00000361842 ; ENSP00000354822 ; ENSG00000132530 . [Q6GPH4-1 ]
    ENST00000571673 ; ENSP00000461196 ; ENSG00000132530 . [Q6GPH4-4 ]
    ENST00000574962 ; ENSP00000458229 ; ENSG00000132530 . [Q6GPH4-3 ]
    GeneIDi 54739.
    KEGGi hsa:54739.
    UCSCi uc002gdm.1. human. [Q6GPH4-1 ]
    uc002gdo.3. human. [Q6GPH4-2 ]
    uc002gdp.4. human. [Q6GPH4-6 ]

    Organism-specific databases

    CTDi 54739.
    GeneCardsi GC17P006659.
    HGNCi HGNC:30932. XAF1.
    HPAi HPA057302.
    MIMi 606717. gene.
    neXtProti NX_Q6GPH4.
    PharmGKBi PA162409299.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87143.
    HOVERGENi HBG108681.
    OrthoDBi EOG73806B.
    PhylomeDBi Q6GPH4.
    TreeFami TF331416.

    Enzyme and pathway databases

    Reactomei REACT_25162. Interferon alpha/beta signaling.

    Miscellaneous databases

    ChiTaRSi XAF1. human.
    GeneWikii XAF1.
    GenomeRNAii 54739.
    NextBioi 57333.
    PROi Q6GPH4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6GPH4.
    Bgeei Q6GPH4.
    CleanExi HS_XAF1.
    Genevestigatori Q6GPH4.

    Family and domain databases

    InterProi IPR001293. Znf_TRAF.
    [Graphical view ]
    PROSITEi PS50145. ZF_TRAF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH BIRC4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    2. "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses."
      Chung S.K., Lee M.G., Ryu B.K., Lee J.H., Han J., Byun D.S., Chae K.S., Lee K.Y., Jang J.Y., Kim H.J., Chi S.G.
      Gastroenterology 132:2459-2477(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6).
      Tissue: Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7).
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-57.
      Tissue: Endometrium.
    7. "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis."
      Leaman D.W., Chawla-Sarkar M., Vyas K., Reheman M., Tamai K., Toji S., Borden E.C.
      J. Biol. Chem. 277:28504-28511(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    8. "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1."
      Yin W., Cheepala S., Clifford J.L.
      Biochem. Biophys. Res. Commun. 339:1148-1154(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP."
      Xia Y., Novak R., Lewis J., Duckett C.S., Phillips A.C.
      Mol. Cell. Biochem. 286:67-76(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN TNF-ALPHA-INDUCED APOPTOSIS, NEGATIVE INTERACTION WITH BIRC4.
    10. "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex."
      Arora V., Cheung H.H., Plenchette S., Micali O.C., Liston P., Korneluk R.G.
      J. Biol. Chem. 282:26202-26209(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN BIRC5 DEGRADATION, INTERACTION WITH BIRC1; BIRC2; BIRC3; BIRC4; BIRC7 AND BIRC8.
    11. "XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway."
      Straszewski-Chavez S.L., Visintin I.P., Karassina N., Los G., Liston P., Halaban R., Fadiel A., Mor G.
      J. Biol. Chem. 282:13059-13072(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN TNF-ALPHA-INDUCED APOPTOSIS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    12. "ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.)."
      Han J., Kim Y.L., Lee K.W., Her N.G., Ha T.K., Yoon S., Jeong S.I., Lee J.H., Kang M.J., Lee M.G., Ryu B.K., Baik J.H., Chi S.G.
      Cell Death Differ. 20:1055-1067(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF114.

    Entry informationi

    Entry nameiXAF1_HUMAN
    AccessioniPrimary (citable) accession number: Q6GPH4
    Secondary accession number(s): A2T931
    , A2T932, A8K2L1, A8K9Y3, D3DTM6, Q6MZE8, Q8N557, Q99982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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