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Protein

Protein fem-1 homolog B

Gene

fem1b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog B
Short name:
FEM1b
Alternative name(s):
FEM1-beta
Gene namesi
Name:fem1b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-999859. fem1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245341 – 629Protein fem-1 homolog BAdd BLAST629

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GPE5.
SMRiQ6GPE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 77ANK 1Add BLAST31
Repeati89 – 118ANK 2Add BLAST30
Repeati122 – 151ANK 3Add BLAST30
Repeati155 – 184ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 250ANK 6Add BLAST31
Repeati346 – 379TPRAdd BLAST34
Repeati485 – 529ANK 7Add BLAST45
Repeati533 – 570ANK 8Add BLAST38

Sequence similaritiesi

Belongs to the fem-1 family.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

HOVERGENiHBG057774.
KOiK10349.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.10.10.10. 1 hit.
1.25.40.20. 5 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 8 hits.
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 6 hits.

Sequencei

Sequence statusi: Complete.

Q6GPE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDGLAGYV YKAAAEGRVL TLAALLLHRT EPEIRTLLST VTQHGGQRST
60 70 80 90 100
PLIIAARNGH SKVVRLLLEH YKVDVQQTGT VRFDGYIIDG ATALWCAAGA
110 120 130 140 150
GHYEVVKLLV SHEANVNHTT VTNSTPLRAA CFDGRLDIVR FLVENNANIS
160 170 180 190 200
IANKYDNTCL MIAAYKGHSD VVHYLLRQHA DPNARAHCGA TALHFAAEAG
210 220 230 240 250
HLDIVRELVK WKAAMVVNGH GMTPLKVAAE SCKADVVELL LAHSDCDAKS
260 270 280 290 300
RIEALELLGA SFANDRENYN ITKTYQYLYL AMLERFRDPS NILHKEVLPP
310 320 330 340 350
IEAYGMRTEC RNPQELGAIL HNTDDLHLEG LIVRERILGS DNIDVSHPII
360 370 380 390 400
YRGAVYADNM QFEQCIKLWL HALQLRQKGN RNTHKDLLRF AQVFSQMIHL
410 420 430 440 450
NEPVKSRDVE RVLECSVLEI ERGIARIQNP QEPDAHSTLE NHECNLYTFL
460 470 480 490 500
YLVCISTKTC CSEEEQPCIN KQIYRLVHLD PRTREGGSLL HLAVDSGTPV
510 520 530 540 550
DDFHTNDVCS FPSAPVAKLL IDCGANVNAV DQMGNSPLHV IVQYNRPISD
560 570 580 590 600
FLTLHAIIIS LVEAGAHTDM TNKEKKTPLD RSTTGVSEIL LKTQMKLSLK
610 620
CLAARAVRLH NIKYQNQIPR TLEEFVEFH
Length:629
Mass (Da):70,274
Last modified:July 19, 2004 - v1
Checksum:i6065D4E0A852EC47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073194 mRNA. Translation: AAH73194.1.
RefSeqiNP_001085685.1. NM_001092216.1.
UniGeneiXl.11486.

Genome annotation databases

GeneIDi444111.
KEGGixla:444111.

Similar proteinsi

Entry informationi

Entry nameiFEM1B_XENLA
AccessioniPrimary (citable) accession number: Q6GPE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 19, 2004
Last modified: October 25, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families