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Protein

Rho GTPase-activating protein 32

Gene

arhgap32

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 32
Alternative name(s):
Rho-type GTPase-activating protein 32
Rho/Cdc42/Rac GTPase-activating protein RICS
Gene namesi
Name:arhgap32
Synonyms:rics
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1002479. arhgap32.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003452051 – 1940Rho GTPase-activating protein 32Add BLAST1940

Structurei

3D structure databases

ProteinModelPortaliQ6GPD0.
SMRiQ6GPD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 248PX; atypicalAdd BLAST95
Domaini262 – 324SH3PROSITE-ProRule annotationAdd BLAST63
Domaini375 – 570Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1069 – 1074Poly-Pro6
Compositional biasi1107 – 1110Poly-Pro4

Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositides.By similarity

Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOVERGENiHBG108407.
KOiK20647.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiView protein in InterPro
IPR036871. PX_dom_sf.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00620. RhoGAP. 1 hit.
PF07653. SH3_2. 1 hit.
SMARTiView protein in SMART
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiView protein in PROSITE
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GPD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGGTDAAAF AAFPSIHAVP STSGRMVTGS KLDELERIMK SSLHLEEDDF
60 70 80 90 100
VPELPRSIHP RERPDWEETI SAMARGADIT VPGEIQIPAE LPLRSCGSTA
110 120 130 140 150
SMKVKNVKKL SFTKGHFPKL AECAHFHYEN VDFGSIQLTL TEDQNEVNRN
160 170 180 190 200
GCESKELVFL VQIACQGRSW IVKRSYEDFR VLDKHLHLCI YDRRFSQLSE
210 220 230 240 250
LPRSDSVKDN PELVTQMLMA YLSRLSAIAG NKINCGPALT WMEIDNKGNH
260 270 280 290 300
LLVHEESSIN VPAIAAAHVI KRYNAQAPDE LSFEVGDIVS VIDMPPKELT
310 320 330 340 350
TWWRGKHGFQ VGFFPSECVE LINDKVPQSM TNSVPKPVSR KHGKLITFLR
360 370 380 390 400
TFMKSRPSKQ KLKQRGILRE RVFGCDLGEH LLNSGQDVPQ VLRSCTEFIE
410 420 430 440 450
KHGVVDGIYR LSGIASNIQK LRHEFDSEQI PDLTKDVYIQ DIHCVGSLCK
460 470 480 490 500
LYFRELPNPL LTYQLYEKFS DAVSAASDEE RLVKIHDVIQ QLPPPHYRTL
510 520 530 540 550
EFLMRHLSRL ATYCSITNMH TKNLAIVWAP NLLRSKQIES ACFSGTAAFM
560 570 580 590 600
EVRIQSVVVE FILNHVEVLF SAKLSSVIRE GAGHTSLSRP KSLLVSSPST
610 620 630 640 650
KLLSLEEAQA RTQAQINSPV VGDSRYIEVG EGPAALQGRF HTVIDFPSER
660 670 680 690 700
KRPPSKMKKS PVGSWRSFFN IGKSSSSSSM SKRKLQRNPS EPLEMKSMAF
710 720 730 740 750
AGGRDSSAMR SAKSEESLSS LHAADGESKL FRPRRPRSSS DALSASYNGD
760 770 780 790 800
LLDSCNRCNS YDNLPRDHDS DGDEGLIHVP AMLSGRSPED EDLSPPDIGM
810 820 830 840 850
ATLDFDPMSF QCSPHQLDSE GPDNFFQLDI FASNGKDKLQ SGTQNPGSVT
860 870 880 890 900
GCEPLSPFQD KVISPFLSPD RSPSTDKVSK TASFAEKFVQ ALSPKMGRKA
910 920 930 940 950
VRSPPLTISD PVSISLPSRV SEMIGSMPGN SAASQSIIWN RESSTNSRES
960 970 980 990 1000
ETYYGCKLVD ANLSSSSATA DPWSTVTPVI TCNQDGREDK AGIFTHGFPQ
1010 1020 1030 1040 1050
PLESSDLEYI ENYNLELGTT NVAAAYQNDD TELSRANQNK AHPPNSPQGA
1060 1070 1080 1090 1100
SASESPQELS HVSSVSIIPP PPPPKNPARM LALALAESAQ QASANKKPSF
1110 1120 1130 1140 1150
MQFMDLPPPP SVPEDKPLLE FSPKMSPEPL RSGPATPAAS PPVISRKTSP
1160 1170 1180 1190 1200
ATPPSTTSSF SVTTIHHSPV KNYNPLAGQM PTAVTPGLSP SSNQVFASVP
1210 1220 1230 1240 1250
DMLHSETIKM NSIIPSEAFT TGIPVTPPTE KTKESSRAPH LHQRSESFPS
1260 1270 1280 1290 1300
HPAYSTAKPT PPVRTMDSRL ATAMHSNFND SITANNYHSF LNTMMLPSSL
1310 1320 1330 1340 1350
EDALPRHNYS PHLKTGNIDE EGVNYRQTYL SHNKQDDPAD LGDLYRQPYI
1360 1370 1380 1390 1400
SPGKSENAEI GNAYRHPYPS NTESESLKEP LEPFLHHKPA VAPKTYRAET
1410 1420 1430 1440 1450
LLPHIPPQVY GSRCDTPSSA FYGTYINQAK HPRSRNKPDY MPSMSPGVRS
1460 1470 1480 1490 1500
YTEDTSSYPT IRRVQSLHVP MQTLPPPIRT VPISRTEVPP DDDPAYCPRP
1510 1520 1530 1540 1550
LYQYKQCPPF NSQSDYHVTQ LQPYFENGRV HYRYSPYSGG PTYFSSDSNF
1560 1570 1580 1590 1600
YDMDPYGTLR LRQLPLYPSR DFASYTTRLQ PKATYRSQGL PPYPRGTLRE
1610 1620 1630 1640 1650
HNFISRDVPP ALPPEHPRPL HISWDMEDMD RYRLQSLRRE NKARQRAKGP
1660 1670 1680 1690 1700
VMSQYDNVTP SLVEDVAGLD VIHLRSRSDP GKTPGLLSVA ETKDVRYPGR
1710 1720 1730 1740 1750
TEGDERTTYP PPVFGNGHQD KPSLPQKQSG SSRSRMQHDI STEQHSQDTL
1760 1770 1780 1790 1800
HRQPSEGRNG PPIPPVDYNA KGMPNPPDPT SYHSSANKYN LTQQEPMRLN
1810 1820 1830 1840 1850
HKELRLTEDI ERSHTRPADN QHRDCYREEQ AQFASVVPPP KPERSHSLRA
1860 1870 1880 1890 1900
HNPAVLERDP SIFYPYQTLH AKRQSTINTV SQYDNLSDYH SIPHHRTTNQ
1910 1920 1930 1940
STPNAFPLPH GRTYSTALGQ GAFLAAELAL QRPETKIHVE
Length:1,940
Mass (Da):216,024
Last modified:July 19, 2004 - v1
Checksum:i7E3BCF52E0D00D33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073211 mRNA. Translation: AAH73211.1.
RefSeqiNP_001085694.1. NM_001092225.1.
UniGeneiXl.34587.

Genome annotation databases

GeneIDi444120.
KEGGixla:444120.

Similar proteinsi

Entry informationi

Entry nameiRHG32_XENLA
AccessioniPrimary (citable) accession number: Q6GPD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families