Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

F-box-like/WD repeat-containing protein TBL1XR1-B

Gene

tbl1xr1-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

F-box-like protein which acts as an integral component of the N-CoR transcriptional corepressor complex. Probably regulates transcription activation mediated by nuclear receptors. May mediate the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of the N-CoR complex, thereby allowing cofactor exchange and transcription activation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box-like/WD repeat-containing protein TBL1XR1-B
Alternative name(s):
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1-B
TBL1-related protein 1-B
Transducin beta-like 1X-related homolog 1-B
Gene namesi
Name:tbl1xr1-b
Synonyms:tblr1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864821. tbl1xr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522F-box-like/WD repeat-containing protein TBL1XR1-BPRO_0000051269Add
BLAST

Interactioni

Subunit structurei

Interacts with heterodimers of rxra and thrb, and this interaction is abrogated by thyroid hormone binding to thrb. Interacts with ncor1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GPC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 3633LisHPROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8646F-box-likeAdd
BLAST
Repeati175 – 21440WD 1Add
BLAST
Repeati231 – 27040WD 2Add
BLAST
Repeati272 – 31140WD 3Add
BLAST
Repeati314 – 35239WD 4Add
BLAST
Repeati355 – 39440WD 5Add
BLAST
Repeati397 – 44549WD 6Add
BLAST
Repeati448 – 48740WD 7Add
BLAST
Repeati489 – 52234WD 8Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 12214Poly-AlaAdd
BLAST

Domaini

The F-box-like domain is related to the F-box domain, and also functions to recruit ubiquitin E3 ligase complexes.By similarity

Sequence similaritiesi

Belongs to the WD repeat EBI family.Curated
Contains 1 F-box-like domain.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG050240.
KOiK04508.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GPC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI
60 70 80 90 100
SIIQKGLQYV EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR
110 120 130 140 150
DKLAQQQQAA AAAAAAAAAA AATSANNQQP PAKNGESTAN GEENGGHALA
160 170 180 190 200
NNHTDMMEVD GDVEIPPSKA VVLRGHESEV FICAWNPVSD LLASGSGDST
210 220 230 240 250
ARIWNLSENS TSGSTQLVLR HCIREGGQDV PSNKDVTSLD WNSEGTLLAT
260 270 280 290 300
GSYDGFARIW TKDGNLASTL GQHKGPIFAL KWNKKGNFIL SAGVDKTTII
310 320 330 340 350
WDAHTGEAKQ QFPFHSAPAL DVDWQSNNTF ASCSTDMCIH VCKLGQDRPI
360 370 380 390 400
KTFQGHTNEV NAIKWDPTGN LLASCSDDMT LKIWSMKHDT CVHDLQAHNK
410 420 430 440 450
EIYTIKWSPT GPGTNNPNAN LMLASASFDS TVRLWDVDRG ICIHTLTKHQ
460 470 480 490 500
EPVYSVAFSP DGRYLASGSF DKCVHIWNTQ TGALVHSYRG TGGIFEVCWN
510 520
AAGDKVGASA SDGSVCVLDL RK
Length:522
Mass (Da):56,285
Last modified:July 19, 2004 - v1
Checksum:i4FB0F58F503B461F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073215 mRNA. Translation: AAH73215.1.
RefSeqiNP_001090456.1. NM_001096987.1.
UniGeneiXl.57610.

Genome annotation databases

GeneIDi779369.
KEGGixla:779369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073215 mRNA. Translation: AAH73215.1.
RefSeqiNP_001090456.1. NM_001096987.1.
UniGeneiXl.57610.

3D structure databases

ProteinModelPortaliQ6GPC6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi779369.
KEGGixla:779369.

Organism-specific databases

CTDi779369.
XenbaseiXB-GENE-864821. tbl1xr1.

Phylogenomic databases

HOVERGENiHBG050240.
KOiK04508.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiTB1RB_XENLA
AccessioniPrimary (citable) accession number: Q6GPC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 19, 2004
Last modified: September 16, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.