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Protein

tRNA-splicing endonuclease subunit Sen2

Gene

tsen2

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.UniRule annotation

Catalytic activityi

PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processtRNA processingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-splicing endonuclease subunit Sen2UniRule annotation (EC:4.6.1.16UniRule annotation)
Gene namesi
Name:tsen2Imported
Synonyms:MGC80553Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5907126 tsen2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GPB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 324tRNA_int_endo_NInterPro annotationAdd BLAST47
Domaini334 – 418tRNA_int_endoInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the tRNA-intron endonuclease family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG056610
KOiK15322

Family and domain databases

Gene3Di3.40.1350.10, 1 hit
InterProiView protein in InterPro
IPR011856 tRNA_endonuc-like_dom_sf
IPR036167 tRNA_intron_Endo_cat-like_sf
IPR006677 tRNA_intron_Endonuc_cat-like
IPR006678 tRNA_intron_Endonuc_N
IPR006676 tRNA_splic
IPR016589 tRNA_splic_SEN2
PANTHERiPTHR21227 PTHR21227, 1 hit
PfamiView protein in Pfam
PF01974 tRNA_int_endo, 1 hit
PF02778 tRNA_int_endo_N, 1 hit
PIRSFiPIRSF011789 tRNA_splic_SEN2, 1 hit
SUPFAMiSSF53032 SSF53032, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKATFHAPK RKRKVYESYE SPFPIPLAHD HSSRDFHICQ AEILNNHVIV
60 70 80 90 100
RSTEDIELLY GKGYFGKGIL SRSRPQHSIA EQQLQSKWKD IKVNLPIISS
110 120 130 140 150
RRYKLHLEWA KNLLEEQGLG TESINKILAD YTREVDISAE GDVVEENPPA
160 170 180 190 200
ESRMDLDPEN GTKSQSSDSN PGKESEGKVF LEGNPEYDPL AKYGPEVLQE
210 220 230 240 250
ERAEEEPDRN KLEKVHCPKH DDFILHCGCK PRRETLQNEL DSPARPHMEY
260 270 280 290 300
LLVEEVQENV DLGPEGTEEN KGARGRGRLV CRRNPFRIFE YLQLSREEAF
310 320 330 340 350
FLVYALGCLT ISYKKEPLTI QKLWEVFCAA QPSFSTKYLA YHHFRSKGWV
360 370 380 390 400
PKVGLKYGTD LLLYRKGPPF YHASYSVIVE LVNDKGEGTP LRPLSWRSLA
410 420 430 440 450
GLHRTTANVS KELLFCYLIK PAGFTDSDFI SPACIHRIKV QELIVSRWVS
460
SRERMDHEEL
Length:460
Mass (Da):52,870
Last modified:July 19, 2004 - v1
Checksum:iEB3B8BEAF3262E10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073227 mRNA Translation: AAH73227.1
RefSeqiNP_001085705.1, NM_001092236.1
XP_018095838.1, XM_018240349.1
XP_018095840.1, XM_018240351.1
XP_018095841.1, XM_018240352.1
UniGeneiXl.34894

Genome annotation databases

GeneIDi444131
KEGGixla:444131

Similar proteinsi

Entry informationi

Entry nameiQ6GPB4_XENLA
AccessioniPrimary (citable) accession number: Q6GPB4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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