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Q6GPA7

- HDAC8_XENLA

UniProt

Q6GPA7 - HDAC8_XENLA

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Protein

Histone deacetylase 8

Gene

hdac8

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

Binds 1 divalent metal cation per subunit.

Enzyme regulationi

Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491SubstrateBy similarity
Active sitei91 – 911Proton acceptorBy similarity
Binding sitei99 – 991Substrate; via carbonyl oxygenBy similarity
Metal bindingi126 – 1261Divalent metal cationBy similarity
Metal bindingi128 – 1281Divalent metal cationBy similarity
Metal bindingi215 – 2151Divalent metal cationBy similarity
Binding sitei254 – 2541SubstrateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 8 (EC:3.5.1.98)
Short name:
HD8
Gene namesi
Name:hdac8
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5863488. hdac8.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Histone deacetylase 8PRO_0000389510Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6GPA7.
SMRiQ6GPA7. Positions 3-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 272272Histone deacetylaseBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG057112.
KOiK11405.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q6GPA7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRVVKPKVA SMEEMAAFHT DAYLQHLHKV SEEGDNDDPE TLEYGLGYDC
60 70 80 90 100
PITEGIYDYA AAVGGATLTA AEQLIEGKTR IAVNWPGGWH HAKKDEASGF
110 120 130 140 150
CYLNDAVLGI LKLREKFDRV LYVDMDLHHG DGVEDAFSFT SKVMTVSLHK
160 170 180 190 200
FSPGFFPGTG DVSDIGLGKG RYYSINVPLQ DGIQDDKYYQ ICEGVLKEVF
210 220 230 240 250
TTFNPEAVVL QLGADTIAGD PMCSFNMTPE GIGKCLKYVL QWQLPTLILG
260 270 280 290 300
GGGYHLPNTA RCWTYLTALI VGRTLSSEIP DHEFFTEYGP DYVLEITPSC
310 320
RPDRNDTQKV QEILQSIKGN LKRVV
Length:325
Mass (Da):36,006
Last modified:July 19, 2004 - v1
Checksum:i409E71978A0439AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC073234 mRNA. Translation: AAH73234.1.
RefSeqiNP_001085711.1. NM_001092242.1.
UniGeneiXl.7001.

Genome annotation databases

GeneIDi444137.
KEGGixla:444137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC073234 mRNA. Translation: AAH73234.1 .
RefSeqi NP_001085711.1. NM_001092242.1.
UniGenei Xl.7001.

3D structure databases

ProteinModelPortali Q6GPA7.
SMRi Q6GPA7. Positions 3-325.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 444137.
KEGGi xla:444137.

Organism-specific databases

CTDi 55869.
Xenbasei XB-GENE-5863488. hdac8.

Phylogenomic databases

HOVERGENi HBG057112.
KOi K11405.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiHDAC8_XENLA
AccessioniPrimary (citable) accession number: Q6GPA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3