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Protein

Histone deacetylase 8

Gene

hdac8

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

a divalent metal cationNote: Binds 1 divalent metal cation per subunit.

Enzyme regulationi

Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491SubstrateBy similarity
Active sitei91 – 911Proton acceptorBy similarity
Binding sitei99 – 991Substrate; via carbonyl oxygenBy similarity
Metal bindingi126 – 1261Divalent metal cationBy similarity
Metal bindingi128 – 1281Divalent metal cationBy similarity
Metal bindingi215 – 2151Divalent metal cationBy similarity
Binding sitei254 – 2541SubstrateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 8 (EC:3.5.1.98)
Short name:
HD8
Gene namesi
Name:hdac8
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5863488. hdac8.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Histone deacetylase 8PRO_0000389510Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6GPA7.
SMRiQ6GPA7. Positions 3-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 272272Histone deacetylaseBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG057112.
KOiK11405.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q6GPA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVVKPKVA SMEEMAAFHT DAYLQHLHKV SEEGDNDDPE TLEYGLGYDC
60 70 80 90 100
PITEGIYDYA AAVGGATLTA AEQLIEGKTR IAVNWPGGWH HAKKDEASGF
110 120 130 140 150
CYLNDAVLGI LKLREKFDRV LYVDMDLHHG DGVEDAFSFT SKVMTVSLHK
160 170 180 190 200
FSPGFFPGTG DVSDIGLGKG RYYSINVPLQ DGIQDDKYYQ ICEGVLKEVF
210 220 230 240 250
TTFNPEAVVL QLGADTIAGD PMCSFNMTPE GIGKCLKYVL QWQLPTLILG
260 270 280 290 300
GGGYHLPNTA RCWTYLTALI VGRTLSSEIP DHEFFTEYGP DYVLEITPSC
310 320
RPDRNDTQKV QEILQSIKGN LKRVV
Length:325
Mass (Da):36,006
Last modified:July 19, 2004 - v1
Checksum:i409E71978A0439AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073234 mRNA. Translation: AAH73234.1.
RefSeqiNP_001085711.1. NM_001092242.1.
UniGeneiXl.7001.

Genome annotation databases

GeneIDi444137.
KEGGixla:444137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073234 mRNA. Translation: AAH73234.1.
RefSeqiNP_001085711.1. NM_001092242.1.
UniGeneiXl.7001.

3D structure databases

ProteinModelPortaliQ6GPA7.
SMRiQ6GPA7. Positions 3-325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444137.
KEGGixla:444137.

Organism-specific databases

CTDi55869.
XenbaseiXB-GENE-5863488. hdac8.

Phylogenomic databases

HOVERGENiHBG057112.
KOiK11405.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiHDAC8_XENLA
AccessioniPrimary (citable) accession number: Q6GPA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.