Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6GPA7 (HDAC8_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 8
Short name=HD8
EC=3.5.1.98
Gene names
Name:hdac8
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactor

Binds 1 divalent metal cation per subunit.

Enzyme regulation

Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Histone deacetylase 8
PRO_0000389510

Regions

Region1 – 272272Histone deacetylase By similarity

Sites

Active site911Proton acceptor By similarity
Metal binding1261Divalent metal cation By similarity
Metal binding1281Divalent metal cation By similarity
Metal binding2151Divalent metal cation By similarity
Binding site491Substrate By similarity
Binding site991Substrate; via carbonyl oxygen By similarity
Binding site2541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GPA7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 409E71978A0439AC

FASTA32536,006
        10         20         30         40         50         60 
MSRVVKPKVA SMEEMAAFHT DAYLQHLHKV SEEGDNDDPE TLEYGLGYDC PITEGIYDYA 

        70         80         90        100        110        120 
AAVGGATLTA AEQLIEGKTR IAVNWPGGWH HAKKDEASGF CYLNDAVLGI LKLREKFDRV 

       130        140        150        160        170        180 
LYVDMDLHHG DGVEDAFSFT SKVMTVSLHK FSPGFFPGTG DVSDIGLGKG RYYSINVPLQ 

       190        200        210        220        230        240 
DGIQDDKYYQ ICEGVLKEVF TTFNPEAVVL QLGADTIAGD PMCSFNMTPE GIGKCLKYVL 

       250        260        270        280        290        300 
QWQLPTLILG GGGYHLPNTA RCWTYLTALI VGRTLSSEIP DHEFFTEYGP DYVLEITPSC 

       310        320 
RPDRNDTQKV QEILQSIKGN LKRVV

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC073234 mRNA. Translation: AAH73234.1.
RefSeqNP_001085711.1. NM_001092242.1.
UniGeneXl.7001.

3D structure databases

HSSPHSSP built from PDB template 1W22 based on UniProtKB Q9BY41.
ProteinModelPortalQ6GPA7.
SMRQ6GPA7. Positions 3-325.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID444137.
KEGGxla:444137.

Organism-specific databases

CTD55869.
XenbaseXB-GENE-5863488. hdac8.

Phylogenomic databases

HOVERGENHBG057112.
KOK11405.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Entry information

Entry nameHDAC8_XENLA
AccessionPrimary (citable) accession number: Q6GPA7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: July 19, 2004
Last modified: March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents