Reviewed, UniProtKB/Swiss-Prot Q6GP95 (GLPK5_XENLA)

Names and origin

Protein names

Recommended name:
    Putative glycerol kinase 5
      Short name=Glycerokinase 5
      Short name=GK 5
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase 5

Gene names

Name:

gk5

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Putative glycerol kinase 5		PRO_0000323758
Regions
	Nucleotide binding	431 – 436	6	ATP By similarity
Sites
	Binding site	20	1	Substrate By similarity
	Binding site	90	1	Substrate By similarity
	Binding site	267	1	Substrate By similarity
	Binding site	289	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GP95-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: FB94D2F661C287D0	FASTA	479	52,028
	10 20 30 40 50 60 MSSPRNGYRD RLILAVDVGS SVLRCHLYNQ SGEICGSAED KLKVLYPQAG YVEIDPESLW 70 80 90 100 110 120 EQFVRVVKEA VADAGIQMSQ VAGLGISTQR GTFITWNKKT GETFHNFISW QDLRAADLVS 130 140 150 160 170 180 SWNRSLLLKA VHGVCTALHF FTRRKRFLAA SLINFTTQHV SLRLVWVLQN IPQVRQAAEK 190 200 210 220 230 240 GNCCFGTIDT WLLHKLTKGT VFATDYSNAS GTAVFDPYLM CWSSFLCSLL SIPLSIFPPV 250 260 270 280 290 300 EDTSHSFGLA DPTIFGAPVP ILALVADQQA AMFGQCCFDV GSVKLTMGTG SFISINTGET 310 320 330 340 350 360 LHTSIAGLYP LIGWKVGDEV VCLAEGNASD TGTAIKWAEE LNLFTSVADT EAMARSVPDC 370 380 390 400 410 420 GGIYLVPSFS GLQAPINDPY ACASFMGLKP STSKSHLVRA ILESVAYRNK QLYDTVLRET 430 440 450 460 470 TIPITLIRAD GGVSNNNFIM QMTADLLGQT IDKPKHTDMS SLGAAFLAGM AVYGPLKTS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC073246 mRNA. Translation: AAH73246.1.
RefSeq	NP_001085720.1.
UniGene	Xl.18511
3D structure databases
HSSP	HSSP built from PDB template 1GLC based on UniProtKB P0A6F3.
SMR	Q6GP95. Positions 12-472.
ModBase	Search...
Genome annotation databases
GeneID	444147.
KEGG	xla:444147.
Organism-specific databases
Xenbase	XB-FEAT-983228. gk5.
Phylogenomic databases
HOVERGEN	Q6GP95.
Enzyme and pathway databases
BRENDA	2.7.1.30. 648.
Family and domain databases
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK5_XENLA

Accession

Primary (citable) accession number: Q6GP95

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2004
Last modified:	January 19, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project