Q6GP62 (VPS29_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein sorting-associated protein 29
EC=3.1.3.3

Alternative name(s):
Vesicle protein sorting 29

Gene names

Name:

vps29

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (igf2r and m6pr) from endosomes to the trans-Golgi network. Has low protein phosphatase activity By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the VPS29 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Vacuolar protein sorting-associated protein 29		PRO_0000339652

Sequences

	Sequence		Length	Mass (Da)
	Q6GP62 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: E1DB51F86D8105EC	FASTA	182	20,450
	10 20 30 40 50 60 MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESFDYLK TLAGDVHIVR 70 80 90 100 110 120 GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQLDVDI LISGHTQKFE 130 140 150 160 170 180 AFEHENKFYI NPGSATGAYN ALENNIIPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK KS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC073281 mRNA. Translation: AAH73281.1. BC097520 mRNA. Translation: AAH97520.1.
RefSeq	NP_001085746.1. NM_001092277.1.
UniGene	Xl.15266.
3D structure databases
HSSP	HSSP built from PDB template 1W24 based on UniProtKB Q9UBQ0.
ProteinModelPortal	Q6GP62.
SMR	Q6GP62. Positions 1-182.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	444173.
KEGG	xla:444173.
Organism-specific databases
CTD	51699.
Xenbase	XB-GENE-967958. vps29.
Phylogenomic databases
HOVERGEN	HBG056165.
Family and domain databases
InterPro	IPR024654. Calcineurin-like_PEstase_dom. IPR000979. Phosphodiesterase_MJ0936. [Graphical view]
KO	K07095.
PANTHER	PTHR11124. PTHR11124. 1 hit.
Pfam	PF12850. Metallophos_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00040. YfcE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VPS29_XENLA

Accession

Primary (citable) accession number: Q6GP62

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	July 19, 2004
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program