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Reviewed, UniProtKB/Swiss-Prot Q6GNL7 (FTHFD_XENLA)

Last modified January 19, 2010. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    10-formyltetrahydrofolate dehydrogenase
      Short name=10-FTHFDH
    EC=1.5.1.6
Alternative name(s):
    Aldehyde dehydrogenase family 1 member L1
Gene names
Name: aldh1l1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

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Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the N-terminal section; belongs to the GART family.

In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.

Contains 1 acyl carrier domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 90290210-formyltetrahydrofolate dehydrogenase
PRO_0000315999

Regions

Domain323 – 39270Acyl carrier
Region1 – 203203GART
Region417 – 902486Aldehyde dehydrogenase

Sites

Active site1061Proton donor By similarity
Active site6731 By similarity
Active site7071 By similarity
Site1421Essential for catalytic activity By similarity

Amino acid modifications

Modified residue3541O-(pantetheine 4'-phosphoryl)serine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6GNL7-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: C484728096D4C281

FASTA90299,982
        10         20         30         40         50         60 
MKIAVIGQSL FGREVYRELL KEGHQVVGVF TIPDKNGKAD PLGADAEKDG IPVFKFPRWR 

        70         80         90        100        110        120 
VKGQAIPEVV EKYKALEAEL NVLPFCSQFI PMEVIDCPKH GSIIYHPSIL PRHRGASAIN 

       130        140        150        160        170        180 
WTLMQGDKIG GFTVFWADDG LDTGDILLQR QCEVLPDDTV NTIYNRFLFP EGVKGMVEAV 

       190        200        210        220        230        240 
RLIAEGNAPR IKQPTEGATY DPMQKKENAK INWDQPAEDI HNFIRGNDKV PGAWTVVDDQ 

       250        260        270        280        290        300 
QLTFFGSSFT RNGPAPDGQP LEIPGASRPA LVTKTGLVLF GNDGERLTVK NIQFEDGKMI 

       310        320        330        340        350        360 
PASQYFKTAD SAALQLSEEE QKVSEEIRAA WRRILTNVSE IEDSTDFFKA GAASMDVVRL 

       370        380        390        400        410        420 
VEEVKLKCNG LQLQNEDVYM ATKFEEFIQM VVRRMRGEDG EEELVIDYVE KEINNMTVKI 

       430        440        450        460        470        480 
PHQLFINGQF MDAEGGKSYD TINPTDGTAI CKVSLAQISD IDRAVAAAKE AFENGEWGKM 

       490        500        510        520        530        540 
NPRDRGRLLY RLADLMEEHQ EELATIESID SGAVYTLALK THVGMSIQTF RYFAGWCDKI 

       550        560        570        580        590        600 
QGRTIPINQA RPNRNLTFTR REPIGVCGIV IPWNYPLMML AWKTAACLTA GNTVVLKPAQ 

       610        620        630        640        650        660 
VTPLTALKFA ELSVKAGIPK GVINILPGAG SLIGQRLSDH PDVRKIGFTG STPIGKQIMK 

       670        680        690        700        710        720 
SCAVSNVKKV SLELGGKSPL IIFHDCDLDK AVRMGMSSVF FNKGENCIAA GRLFLEESIH 

       730        740        750        760        770        780 
DEFVKRVVEE VKKMKIGDPL DRSTDHGPQN HKAHLDKLIE YCQTGVKEGG KLVYGGKQVE 

       790        800        810        820        830        840 
RPGFFFEPTI FTDVTDEMFI AKEESFGPVM IISKFNDGDI DGVLKRANDS EFGLASGVFT 

       850        860        870        880        890        900 
KDINKALYVS EKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEEALN EYLKTKAVTI 


EY

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References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC073490 mRNA. Translation: AAH73490.1.
RefSeqNP_001085894.1.
UniGeneXl.5930

3D structure databases

HSSPHSSP built from PDB template 1S3I based on UniProtKB P28037.
SMRQ6GNL7. Positions 1-307, 302-401, 405-902.
ModBaseSearch...

Genome annotation databases

GeneID444321.
KEGGxla:444321.

Organism-specific databases

XenbaseXB-FEAT-1016236. aldh1l1.

Phylogenomic databases

HOVERGENQ6GNL7.

Enzyme and pathway databases

BRENDA1.5.1.6. 648.

Family and domain databases

InterProIPR011407. 10_FTHF_DH.
IPR009081. Acyl_carrier_prot-like.
IPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR006163. Phsphopanteth_bd.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
G3DSA:3.10.25.10. Formyl_trans_C. 1 hit.
G3DSA:3.40.50.170. Formyl_transf_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFPIRSF036489. 10-FTHFDH. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
PS00373. GART. 1 hit.
PS00012. PHOSPHOPANTETHEINE. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameFTHFD_XENLA
AccessionPrimary (citable) accession number: Q6GNL7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents