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Q6GNI6

- UB22A_XENLA

UniProt

Q6GNI6 - UB22A_XENLA

Protein

Ubiquitin carboxyl-terminal hydrolase 22-A

Gene

usp22-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei183 – 1831NucleophilePROSITE-ProRule annotation
    Active sitei477 – 4771Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri44 – 10461UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. chromatin modification Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 22-A (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 22-A
    Ubiquitin thioesterase 22-A
    Ubiquitin-specific-processing protease 22-A
    Gene namesi
    Name:usp22-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5806563. usp22.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Ubiquitin carboxyl-terminal hydrolase 22-APRO_0000367512Add
    BLAST

    Interactioni

    Subunit structurei

    Component of some SAGA transcription coactivator-HAT complexes.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GNI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 518345USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. UBP8 subfamily.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri44 – 10461UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG058014.
    KOiK11366.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GNI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPAGCSHVN SFKVENWKQN LRVIYQCFVW SGTPETRKRK AKSCICHMCG    50
    AHLNRLHSCL YCVFFGCFTK KHIHEHAKNK RHNLAIDLLY GGIYCFMCQD 100
    YIYDKDMEQV AKEEQRKAWK LQVFSPALVS PYQYTMTGVG EKYSTWEPTK 150
    RELELLQHNP KRRKITTNCT IGLRGLINLG NTCFMNCIVQ ALTHTPLLRD 200
    FFLSDRHKCE MQSPNSCLVC EMSTLFQEFY SGHRSPHIPY RLLHLVWTHA 250
    RHLAGYEQQD AHEFLIAALD VLHRHCKGDD NGKKANNPNH CNCIIDQIFT 300
    GGLQSDVTCQ VCHGVSTTID PFWDISLDLP GSSTPFWPLS PGSDAGVVNG 350
    ESHVSGTTTL TDCLRRFTRP EHLGSSAKIK CSGCHSYQES TKQLTMKKLP 400
    IVACFHLKRF EHSAKLRRKI TTYVSFPLEL DMTPFMASSK ESRMNGQYQQ 450
    PSDSLHNDNK YSLFAVVNHQ GTLESGHYTS FIRQHKDQWF KCDDAIITKA 500
    SIKDVLDSEG YLLFYHKQFL EYE 523
    Length:523
    Mass (Da):60,049
    Last modified:July 19, 2004 - v1
    Checksum:i731A0AE1C2E67D61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC073524 mRNA. Translation: AAH73524.1.
    RefSeqiNP_001085912.1. NM_001092443.1.
    UniGeneiXl.25481.

    Genome annotation databases

    GeneIDi444339.
    KEGGixla:444339.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC073524 mRNA. Translation: AAH73524.1 .
    RefSeqi NP_001085912.1. NM_001092443.1.
    UniGenei Xl.25481.

    3D structure databases

    ProteinModelPortali Q6GNI6.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 444339.
    KEGGi xla:444339.

    Organism-specific databases

    CTDi 444339.
    Xenbasei XB-GENE-5806563. usp22.

    Phylogenomic databases

    HOVERGENi HBG058014.
    KOi K11366.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiUB22A_XENLA
    AccessioniPrimary (citable) accession number: Q6GNI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3