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Q6GNI6

- UB22A_XENLA

UniProt

Q6GNI6 - UB22A_XENLA

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Protein
Ubiquitin carboxyl-terminal hydrolase 22-A
Gene
usp22-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831Nucleophile By similarity
Active sitei477 – 4771Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 10461UBP-type
Add
BLAST

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. chromatin modification Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 22-A (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 22-A
Ubiquitin thioesterase 22-A
Ubiquitin-specific-processing protease 22-A
Gene namesi
Name:usp22-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5806563. usp22.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Ubiquitin carboxyl-terminal hydrolase 22-A
PRO_0000367512Add
BLAST

Interactioni

Subunit structurei

Component of some SAGA transcription coactivator-HAT complexes By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6GNI6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 518345USP
Add
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG058014.
KOiK11366.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GNI6-1 [UniParc]FASTAAdd to Basket

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MSPAGCSHVN SFKVENWKQN LRVIYQCFVW SGTPETRKRK AKSCICHMCG    50
AHLNRLHSCL YCVFFGCFTK KHIHEHAKNK RHNLAIDLLY GGIYCFMCQD 100
YIYDKDMEQV AKEEQRKAWK LQVFSPALVS PYQYTMTGVG EKYSTWEPTK 150
RELELLQHNP KRRKITTNCT IGLRGLINLG NTCFMNCIVQ ALTHTPLLRD 200
FFLSDRHKCE MQSPNSCLVC EMSTLFQEFY SGHRSPHIPY RLLHLVWTHA 250
RHLAGYEQQD AHEFLIAALD VLHRHCKGDD NGKKANNPNH CNCIIDQIFT 300
GGLQSDVTCQ VCHGVSTTID PFWDISLDLP GSSTPFWPLS PGSDAGVVNG 350
ESHVSGTTTL TDCLRRFTRP EHLGSSAKIK CSGCHSYQES TKQLTMKKLP 400
IVACFHLKRF EHSAKLRRKI TTYVSFPLEL DMTPFMASSK ESRMNGQYQQ 450
PSDSLHNDNK YSLFAVVNHQ GTLESGHYTS FIRQHKDQWF KCDDAIITKA 500
SIKDVLDSEG YLLFYHKQFL EYE 523
Length:523
Mass (Da):60,049
Last modified:July 19, 2004 - v1
Checksum:i731A0AE1C2E67D61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC073524 mRNA. Translation: AAH73524.1.
RefSeqiNP_001085912.1. NM_001092443.1.
UniGeneiXl.25481.

Genome annotation databases

GeneIDi444339.
KEGGixla:444339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC073524 mRNA. Translation: AAH73524.1 .
RefSeqi NP_001085912.1. NM_001092443.1.
UniGenei Xl.25481.

3D structure databases

ProteinModelPortali Q6GNI6.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 444339.
KEGGi xla:444339.

Organism-specific databases

CTDi 444339.
Xenbasei XB-GENE-5806563. usp22.

Phylogenomic databases

HOVERGENi HBG058014.
KOi K11366.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiUB22A_XENLA
AccessioniPrimary (citable) accession number: Q6GNI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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