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Protein

Ubiquitin carboxyl-terminal hydrolase 22-A

Gene

usp22-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831NucleophilePROSITE-ProRule annotation
Active sitei477 – 4771Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 10461UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 22-A (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 22-A
Ubiquitin thioesterase 22-A
Ubiquitin-specific-processing protease 22-A
Gene namesi
Name:usp22-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5806563. usp22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Ubiquitin carboxyl-terminal hydrolase 22-APRO_0000367512Add
BLAST

Interactioni

Subunit structurei

Component of some SAGA transcription coactivator-HAT complexes.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GNI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 518345USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. UBP8 subfamily.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 10461UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG058014.
KOiK11366.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GNI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAGCSHVN SFKVENWKQN LRVIYQCFVW SGTPETRKRK AKSCICHMCG
60 70 80 90 100
AHLNRLHSCL YCVFFGCFTK KHIHEHAKNK RHNLAIDLLY GGIYCFMCQD
110 120 130 140 150
YIYDKDMEQV AKEEQRKAWK LQVFSPALVS PYQYTMTGVG EKYSTWEPTK
160 170 180 190 200
RELELLQHNP KRRKITTNCT IGLRGLINLG NTCFMNCIVQ ALTHTPLLRD
210 220 230 240 250
FFLSDRHKCE MQSPNSCLVC EMSTLFQEFY SGHRSPHIPY RLLHLVWTHA
260 270 280 290 300
RHLAGYEQQD AHEFLIAALD VLHRHCKGDD NGKKANNPNH CNCIIDQIFT
310 320 330 340 350
GGLQSDVTCQ VCHGVSTTID PFWDISLDLP GSSTPFWPLS PGSDAGVVNG
360 370 380 390 400
ESHVSGTTTL TDCLRRFTRP EHLGSSAKIK CSGCHSYQES TKQLTMKKLP
410 420 430 440 450
IVACFHLKRF EHSAKLRRKI TTYVSFPLEL DMTPFMASSK ESRMNGQYQQ
460 470 480 490 500
PSDSLHNDNK YSLFAVVNHQ GTLESGHYTS FIRQHKDQWF KCDDAIITKA
510 520
SIKDVLDSEG YLLFYHKQFL EYE
Length:523
Mass (Da):60,049
Last modified:July 19, 2004 - v1
Checksum:i731A0AE1C2E67D61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073524 mRNA. Translation: AAH73524.1.
RefSeqiNP_001085912.1. NM_001092443.1.
UniGeneiXl.25481.

Genome annotation databases

GeneIDi444339.
KEGGixla:444339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073524 mRNA. Translation: AAH73524.1.
RefSeqiNP_001085912.1. NM_001092443.1.
UniGeneiXl.25481.

3D structure databases

ProteinModelPortaliQ6GNI6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444339.
KEGGixla:444339.

Organism-specific databases

CTDi444339.
XenbaseiXB-GENE-5806563. usp22.

Phylogenomic databases

HOVERGENiHBG058014.
KOiK11366.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiUB22A_XENLA
AccessioniPrimary (citable) accession number: Q6GNI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 19, 2004
Last modified: March 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.