Q6GNG3 (TMX3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein disulfide-isomerase TMX3
EC=5.3.4.1

Alternative name(s):
Thioredoxin domain-containing protein 10
Thioredoxin-related transmembrane protein 3

Gene names

Name:	tmx3
Synonyms:	txndc10

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds By similarity.
Catalytic activity	Catalyzes the rearrangement of -S-S- bonds in proteins.
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein By similarity.
Domain	The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins By similarity.
Sequence similarities	Belongs to the protein disulfide isomerase family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Redox-active center Signal Transmembrane Transmembrane helix
Molecular function	Isomerase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide isomerase activity Inferred from electronic annotation. Source: EC protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 452	426	Protein disulfide-isomerase TMX3		PRO_0000034188
Regions
	Topological domain	27 – 375	349	Lumenal Potential
	Transmembrane	376 – 396	21	Helical; Potential
	Topological domain	397 – 452	56	Cytoplasmic Potential
	Domain	27 – 128	102	Thioredoxin
	Motif	449 – 452	4	Di-lysine motif
Amino acid modifications
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	313	1	N-linked (GlcNAc...) Potential
	Disulfide bond	53 ↔ 56		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GNG3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: DE4CB700D2255945	FASTA	452	50,861
	10 20 30 40 50 60 MAAAGLCFIL AIVSSTSLLA SVPVSALVED LDDSFKENRK DDIWLVDFYA PWCGHCKKLE 70 80 90 100 110 120 PVWNEVGIEI RTSGSPIRVG KIDATVYSSI ASEFGVRGFP TIKALKGDMA YNYRGPRTKE 130 140 150 160 170 180 DIVEFANRVA GPLIRPLPSQ QMFDHVKKRH PVLFVYVGVE STLKEKFIEV ASELIVYTYF 190 200 210 220 230 240 FSASEDVLPK YVTLNEVPAV LVFKDSTYFV YDEYEDGDLS SWVNKERFEG YLHIDGFTLY 250 260 270 280 290 300 ELGDTGKLVA VAVIDEKNNS IEHTRIKSIA QDVAKNNRNN FHRDFQFGHM DGNDYINSLL 310 320 330 340 350 360 MDELSIPTFV VLNTSNQQYF LPSKHIENPE EMIQFINSIL DGTAEAQGGD GILQRIKRVF 370 380 390 400 410 420 YDAKSTVVSV FKSSPLLGCF LFGLPLGVIS IMCYGICTAD TEDGSEEMTR KDVIDQNASD 430 440 450 EGSDEEEEKG REITDVSDED QQEKDFMEKK ID

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC073549 mRNA. Translation: AAH73549.1.
RefSeq	NP_001085926.1. NM_001092457.1.
UniGene	Xl.33912.
3D structure databases
ProteinModelPortal	Q6GNG3.
ModBase	Search...
Proteomic databases
PRIDE	Q6GNG3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	444355.
KEGG	xla:444355.
Organism-specific databases
CTD	444355.
Xenbase	XB-GENE-946771. tmx3.
Family and domain databases
InterPro	IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K09585.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PRINTS	PR00421. THIOREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 2 hits.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TMX3_XENLA

Accession

Primary (citable) accession number: Q6GNG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	July 19, 2004
Last modified:	November 16, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program