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Protein
Submitted name:

MGC83034 protein

Gene

capn9

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97PROSITE-ProRule annotation1
Active sitei254PROSITE-ProRule annotation1
Active sitei278PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi574 – 585PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi604 – 615PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Protein family/group databases

MEROPSiC02.006.

Names & Taxonomyi

Protein namesi
Submitted name:
MGC83034 proteinImported
Gene namesi
Name:capn9Imported
Synonyms:MGC83034Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-948348. capn9.

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ6GN47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 337Calpain catalyticInterPro annotationAdd BLAST296
Domaini561 – 587EF-handInterPro annotationAdd BLAST27
Domaini591 – 626EF-handInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

HOVERGENiHBG012645.
KOiK08578.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029542. CAPN9.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF333. PTHR10183:SF333. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GN47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYIYKDPSL KESIAQQTCR SVHSSGKTYE QLKSECLSKG VLFEDVDFPA
60 70 80 90 100
NDSSLFYSEK PSVPFVWKRP KEMVADPEFI LGGASRTDVC QGDLGDCWLL
110 120 130 140 150
AAIASLTLND KILHRVVPPD QPFSTGYAGI FHFQFWQHNE WLDIVIDDRL
160 170 180 190 200
PTFRNRLVFV HSADLNEFWS ALLEKAYAKL NGSYEALKGG STLEAMEDFT
210 220 230 240 250
GGVTETYEIR SAPANLFEIM DKALKKGSML GCSIDISSSS ETEAKTPQGL
260 270 280 290 300
VKGHAYSITA TDVVNFQGQK VKLIRIRNPW GQVEWNGAWS DNSSEWNIIG
310 320 330 340 350
AAEKNRLSQA SLDDGEFWMD FEDFKRHFDK LEICNLTPDA LEEDTKYKWE
360 370 380 390 400
VTVHEGSWIR GSTAGGCRNF LETFWSNPQI KLSLKEQDEG QKDCTFIAAL
410 420 430 440 450
MQKNRRKLRK TGADLLTIGY TIYQCPGSES ILEKDFFKFN ASKARSKTYV
460 470 480 490 500
NLREVCQRFK LPPGDYMFIP TTYEPHQEAD FCLRIFSEKK ADIKEMDGEI
510 520 530 540 550
NVDLPDPTAP TPPPKETEEE RQFRTLFEQI SGQDLEVSAE ELQYVLNSVL
560 570 580 590 600
RRTKNIKFKE MSLLSCNNII SLMDTSGNGK LGFDEFKIFW DKLKTWIGIF
610 620 630 640 650
MQYDLDRSGT MSSYELRLAL KSAGFHLNNI VLQLIVLRYA DDHFQIEFDD
660 670 680 690
FLNCLIRLEN SYRVFKQLNQ SNTIETQAIQ INQAEFIALT MNI
Length:693
Mass (Da):79,224
Last modified:July 19, 2004 - v1
Checksum:i7653686BCB05BB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073673 mRNA. Translation: AAH73673.1.
RefSeqiNP_001085997.1. NM_001092528.1.
UniGeneiXl.47406.

Genome annotation databases

GeneIDi444426.
KEGGixla:444426.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6GN47_XENLA
AccessioniPrimary (citable) accession number: Q6GN47
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)