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Q6GN40 (CNPY3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein canopy homolog 3
Gene names
Name:cnpy3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the canopy family.

Contains 1 saposin B-type domain.

Sequence caution

The sequence AAH73680.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processImmunity
Innate immunity
   Cellular componentEndoplasmic reticulum
   DomainCoiled coil
Signal
   Molecular functionChaperone
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processinnate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 243228Protein canopy homolog 3
PRO_0000313784

Regions

Domain27 – 236210Saposin B-type
Coiled coil136 – 16025 Potential

Amino acid modifications

Disulfide bond29 ↔ 188 By similarity
Disulfide bond32 ↔ 176 By similarity
Disulfide bond86 ↔ 148 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GN40 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 58A8B3DA628BDB8C

FASTA24328,170
        10         20         30         40         50         60 
MWFLFLLLPL WAGCAEPGDS EWVHLPSKCE VCKYVALELK SSFDETSRTR ELIDTRYGFL 

        70         80         90        100        110        120 
EDDKKKKKIK YTTSDIRLIE VTEGLCSRLL EYNLHKERTG SNRFAKGMSE TFQTLHHLVH 

       130        140        150        160        170        180 
KGVKVVMDIP YELWNETSAE VADMKKQCDV MMENYEEVIE DWYRNHQDED LSEFLCARHV 

       190        200        210        220        230        240 
LKGQDQSCLS EQGDSRKGDT GPSTGTKKQK KQGEKKNKSK KQNSGSKEEK KQMDQPMAAK 


EEL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC073680 mRNA. Translation: AAH73680.1. Different initiation.
UniGeneXl.31689.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6251984. cnpy3.

Phylogenomic databases

HOVERGENHBG107736.

Family and domain databases

InterProIPR021852. DUF3456.
[Graphical view]
PfamPF11938. DUF3456. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCNPY3_XENLA
AccessionPrimary (citable) accession number: Q6GN40
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families