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Q6GN40

- CNPY3_XENLA

UniProt

Q6GN40 - CNPY3_XENLA

Protein

Protein canopy homolog 3

Gene

cnpy3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses By similarity.By similarity

    GO - Biological processi

    1. innate immune response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein canopy homolog 3
    Gene namesi
    Name:cnpy3
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6251984. cnpy3.

    Subcellular locationi

    Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 243228Protein canopy homolog 3PRO_0000313784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 188By similarity
    Disulfide bondi32 ↔ 176By similarity
    Disulfide bondi86 ↔ 148By similarity

    Keywords - PTMi

    Disulfide bond

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 236210Saposin B-typeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili136 – 16025Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the canopy family.Curated
    Contains 1 saposin B-type domain.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    HOVERGENiHBG107736.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6GN40-1 [UniParc]FASTAAdd to Basket

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    MWFLFLLLPL WAGCAEPGDS EWVHLPSKCE VCKYVALELK SSFDETSRTR    50
    ELIDTRYGFL EDDKKKKKIK YTTSDIRLIE VTEGLCSRLL EYNLHKERTG 100
    SNRFAKGMSE TFQTLHHLVH KGVKVVMDIP YELWNETSAE VADMKKQCDV 150
    MMENYEEVIE DWYRNHQDED LSEFLCARHV LKGQDQSCLS EQGDSRKGDT 200
    GPSTGTKKQK KQGEKKNKSK KQNSGSKEEK KQMDQPMAAK EEL 243
    Length:243
    Mass (Da):28,170
    Last modified:January 15, 2008 - v2
    Checksum:i58A8B3DA628BDB8C
    GO

    Sequence cautioni

    The sequence AAH73680.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC073680 mRNA. Translation: AAH73680.1. Different initiation.
    UniGeneiXl.31689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC073680 mRNA. Translation: AAH73680.1 . Different initiation.
    UniGenei Xl.31689.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-6251984. cnpy3.

    Phylogenomic databases

    HOVERGENi HBG107736.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiCNPY3_XENLA
    AccessioniPrimary (citable) accession number: Q6GN40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 30 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3