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Q6GN40

- CNPY3_XENLA

UniProt

Q6GN40 - CNPY3_XENLA

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Protein
Protein canopy homolog 3
Gene
cnpy3
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for immune responses By similarity.

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 3
Gene namesi
Name:cnpy3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6251984. cnpy3.

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Chaini16 – 243228Protein canopy homolog 3
PRO_0000313784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 188 By similarity
Disulfide bondi32 ↔ 176 By similarity
Disulfide bondi86 ↔ 148 By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 236210Saposin B-type
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili136 – 16025 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the canopy family.

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

HOVERGENiHBG107736.

Family and domain databases

InterProiIPR021852. DUF3456.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GN40-1 [UniParc]FASTAAdd to Basket

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MWFLFLLLPL WAGCAEPGDS EWVHLPSKCE VCKYVALELK SSFDETSRTR    50
ELIDTRYGFL EDDKKKKKIK YTTSDIRLIE VTEGLCSRLL EYNLHKERTG 100
SNRFAKGMSE TFQTLHHLVH KGVKVVMDIP YELWNETSAE VADMKKQCDV 150
MMENYEEVIE DWYRNHQDED LSEFLCARHV LKGQDQSCLS EQGDSRKGDT 200
GPSTGTKKQK KQGEKKNKSK KQNSGSKEEK KQMDQPMAAK EEL 243
Length:243
Mass (Da):28,170
Last modified:January 15, 2008 - v2
Checksum:i58A8B3DA628BDB8C
GO

Sequence cautioni

The sequence AAH73680.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC073680 mRNA. Translation: AAH73680.1. Different initiation.
UniGeneiXl.31689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC073680 mRNA. Translation: AAH73680.1 . Different initiation.
UniGenei Xl.31689.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-6251984. cnpy3.

Phylogenomic databases

HOVERGENi HBG107736.

Family and domain databases

InterProi IPR021852. DUF3456.
[Graphical view ]
Pfami PF11938. DUF3456. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCNPY3_XENLA
AccessioniPrimary (citable) accession number: Q6GN40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi