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Q6GN16 (PI4KB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylinositol 4-kinase beta
Short name=PI4K-beta
Short name=PI4Kbeta
Short name=PtdIns 4-kinase beta
EC=2.7.1.67
Gene names
Name:pi4kb
Synonyms:pik4cb
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length804 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Subcellular location

Endomembrane system By similarity. Mitochondrion outer membrane; Peripheral membrane protein By similarity. Rough endoplasmic reticulum membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 804804Phosphatidylinositol 4-kinase beta
PRO_0000365170

Regions

Domain55 – 245191PIK helical
Domain547 – 753207PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
Q6GN16 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 9E56D98498F8A128

FASTA80490,455
        10         20         30         40         50         60 
MGDTMVEPVP VKLSDQSLVL RGNGGSALCV ITEGVGEASL VIDPDVAQKA CQEVLEKVKM 

        70         80         90        100        110        120 
IHGSSVESLD KVDGGDAGDG GSLANGDTEP KLTNTGHTST SSRINEEESP LDINSVKNAR 

       130        140        150        160        170        180 
RRQKNNSAKQ SWLLRLFECK LFDVSMAISY LYNSKEPGVQ AYIGNRLFCF RYEDVDFYLP 

       190        200        210        220        230        240 
QLLNMYIHMD EDVGDAIKPY VVHRCRQSIN FSLQCAWLLG AYSSDMHIST QRHSRGTKLR 

       250        260        270        280        290        300 
KLILSDELKP AHKKREIPPL SLAPDTGLSP SKRTHQRSKS DATVSISLSS NLKRTSSNPK 

       310        320        330        340        350        360 
VENDDEPVRL APEREFIKSL MGIGKRLATL PTKEQKTQRL ISELSLLNHK LPARVWLPTA 

       370        380        390        400        410        420 
GFDHHVVRVP HTQAVVLNSK DKAPYLIYVE VLECENFETS LVPVRIPENR IRSTRSVENL 

       430        440        450        460        470        480 
PECGITHEQR ASSFTTVPNY DNDDEAWSVD DIGELQVELP ELHTNSCDNI SQFSVDSITS 

       490        500        510        520        530        540 
QESKDPVFIA AGDIRRRLSE QLAHTPTTFR RDPEDPSAVA LKEPWEEKVR RIREGSPYGH 

       550        560        570        580        590        600 
FPNWRLLSVI VKCGDDLRQE LLASQVLKQL QSIWESERVP LWIRPYKILV ISGDSGMIEP 

       610        620        630        640        650        660 
VVNAVSIHQV KKQSQLSLLH YFLQEHGSCT TEAFLTAQRN FVQSCAAYCL VCYLLQVKDR 

       670        680        690        700        710        720 
HNGNILLDAE GHIIHIDFGF ILSSSPRNLG FETSAFKLTA EFVDVMGGLN GDMFNYYKML 

       730        740        750        760        770        780 
MLQGLIAARK HMDKVVQVVE IMQQGSQLPC FHGSSTIRNL KERFHMNMTE EQLQILVEQM 

       790        800 
VDGSMRSITT KLYDGFQYLT NGIM

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC073706 mRNA. Translation: AAH73706.1.
RefSeqNP_001086017.1. NM_001092548.1.
UniGeneXl.7048.

3D structure databases

HSSPHSSP built from PDB template 1E8Y based on UniProtKB P48736.
ProteinModelPortalQ6GN16.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID444446.
KEGGxla:444446.

Organism-specific databases

CTD5298.
XenbaseXB-GENE-997616. pi4kb.

Phylogenomic databases

HOVERGENHBG053597.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
Gene3DG3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
KOK00888.
PANTHERPTHR10048. PI_Kinase. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePI4KB_XENLA
AccessionPrimary (citable) accession number: Q6GN16
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 19, 2004
Last modified: November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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