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Q6GMX6

- Q6GMX6_HUMAN

UniProt

Q6GMX6 - Q6GMX6_HUMAN

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Protein
Submitted name:

IGH@ protein

Gene

IGH@

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
IGH@ proteinImported
Gene namesi
Name:IGH@Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ6GMX6.

Expressioni

Gene expression databases

BgeeiQ6GMX6.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BEYX-ray3.25H20-233[»]
1ZA6X-ray2.80B/D/F/H124-465[»]
2JIXX-ray3.20D/F/H20-236[»]
3B2UX-ray2.58C/F/H/J/N/Q/T/W20-237[»]
3B2VX-ray3.30H20-237[»]
3D0LX-ray2.35B55-240[»]
3ZL4X-ray1.95H20-238[»]
4D9LX-ray2.48H/I/J/K119-237[»]
4FQQX-ray2.42B/D/F/H20-242[»]
4LKXX-ray1.92A20-243[»]
4NPYX-ray1.80B/H21-238[»]
4QHKX-ray3.49I/K/M/O20-242[»]
4QHLX-ray3.15A/C20-242[»]
4QHMX-ray3.23A/C/E/G20-242[»]
4QHNX-ray3.00A20-242[»]
4R26X-ray2.50H20-239[»]
ProteinModelPortaliQ6GMX6.
SMRiQ6GMX6. Positions 23-462.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6GMX6.

Family & Domainsi

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GMX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGGSISG
60 70 80 90 100
YYWSWIRQPA GKGLEWIGRI YTSGSTNYNP SLKSRVTMSV DTSKNQFSLK
110 120 130 140 150
LSSVTAADTA VYYCARGRFT YFDYWGQGTL VTVSSASTKG PSVFPLAPSS
160 170 180 190 200
KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
210 220 230 240 250
SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP
260 270 280 290 300
ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV
310 320 330 340 350
EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI
360 370 380 390 400
EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE
410 420 430 440 450
SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL
460
HNHYTQKSLS LSPGK
Length:465
Mass (Da):51,083
Last modified:July 19, 2004 - v1
Checksum:iB3A9B7D0FDB1386E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073766 mRNA. Translation: AAH73766.1.
UniGeneiHs.510635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073766 mRNA. Translation: AAH73766.1 .
UniGenei Hs.510635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BEY X-ray 3.25 H 20-233 [» ]
1ZA6 X-ray 2.80 B/D/F/H 124-465 [» ]
2JIX X-ray 3.20 D/F/H 20-236 [» ]
3B2U X-ray 2.58 C/F/H/J/N/Q/T/W 20-237 [» ]
3B2V X-ray 3.30 H 20-237 [» ]
3D0L X-ray 2.35 B 55-240 [» ]
3ZL4 X-ray 1.95 H 20-238 [» ]
4D9L X-ray 2.48 H/I/J/K 119-237 [» ]
4FQQ X-ray 2.42 B/D/F/H 20-242 [» ]
4LKX X-ray 1.92 A 20-243 [» ]
4NPY X-ray 1.80 B/H 21-238 [» ]
4QHK X-ray 3.49 I/K/M/O 20-242 [» ]
4QHL X-ray 3.15 A/C 20-242 [» ]
4QHM X-ray 3.23 A/C/E/G 20-242 [» ]
4QHN X-ray 3.00 A 20-242 [» ]
4R26 X-ray 2.50 H 20-239 [» ]
ProteinModelPortali Q6GMX6.
SMRi Q6GMX6. Positions 23-462.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6GMX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005814.

Miscellaneous databases

EvolutionaryTracei Q6GMX6.

Gene expression databases

Bgeei Q6GMX6.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07654. C1-set. 3 hits.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart."
    Cheetham G.M., Hale G., Waldmann H., Bloomer A.C.
    J. Mol. Biol. 284:85-99(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 20-233, ACTIVE SITE.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Primary B-CellsImported.
  3. "The structure of an antitumor C(H)2-domain-deleted humanized antibody."
    Larson S.B., Day J.S., Glaser S., Braslawsky G., McPherson A.
    J. Mol. Biol. 348:1177-1190(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 124-465, ACTIVE SITE.
  4. "A potent erythropoietin-mimicking human antibody interacts through a novel binding site."
    Liu Z., Stoll V.S., Devries P.J., Jakob C.G., Xie N., Simmer R.L., Lacy S.E., Egan D.A., Harlan J.E., Lesniewski R.R., Reilly E.B.
    Blood 110:2408-2413(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 20-236, ACTIVE SITE.
  5. "Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site."
    Julien J.P., Bryson S., Nieva J.L., Pai E.F.
    J. Mol. Biol. 384:377-392(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 55-240, ACTIVE SITE.
  6. "Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8."
    Li S., Kussie P., Ferguson K.M.
    Structure 16:216-227(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.58 ANGSTROMS) OF 20-237, ACTIVE SITE.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 20-242, ACTIVE SITE.
  8. "Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals."
    Gorny M.K., Pan R., Williams C., Wang X.H., Volsky B., O'Neal T., Spurrier B., Sampson J.M., Li L., Seaman M.S., Kong X.P., Zolla-Pazner S.
    Virology 427:198-207(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 119-237, ACTIVE SITE.
  9. "The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies."
    Sok D., Laserson U., Laserson J., Liu Y., Vigneault F., Julien J.P., Briney B., Ramos A., Saye K.F., Le K., Mahan A., Wang S., Kardar M., Yaari G., Walker L.M., Simen B.B., St John E.P., Chan-Hui P.Y.
    , Swiderek K., Kleinstein S.H., Kleinstein S.H., Alter G., Seaman M.S., Chakraborty A.K., Koller D., Wilson I.A., Church G.M., Burton D.R., Poignard P.
    PLoS Pathog. 9:e1003754-e1003754(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 21-238, ACTIVE SITE.
  10. "Role of ??? light-chain constant-domain switch in the structure and functionality of A17 reactibody."
    Ponomarenko N., Chatziefthimiou S.D., Kurkova I., Mokrushina Y., Mokrushina Y., Stepanova A., Smirnov I., Avakyan M., Bobik T., Mamedov A., Mitkevich V., Belogurov A., Fedorova O.S., Dubina M., Golovin A., Lamzin V., Friboulet A., Makarov A.A., Wilmanns M., Gabibov A.
    Acta Crystallogr. D 70:708-719(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 20-238, ACTIVE SITE.
  11. "Structural Evolution of Glycan Recognition by a Family of Potent HIV Antibodies."
    Garces F., Sok D., Kong L., McBride R., Kim H.J., Saye-Francisco K.F., Julien J.P., Hua Y., Cupo A., Moore J.P., Paulson J.C., Ward A.B., Burton D.R., Wilson I.A.
    Cell 159:69-79(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 20-239, ACTIVE SITE.
  12. "Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains."
    Fera D., Schmidt A.G., Haynes B.F., Gao F., Liao H.X., Kepler T.B., Harrison S.C.
    Proc. Natl. Acad. Sci. U.S.A. 111:10275-10280(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 20-242, ACTIVE SITE.

Entry informationi

Entry nameiQ6GMX6_HUMAN
AccessioniPrimary (citable) accession number: Q6GMX6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3