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Q6GMX6 (Q6GMX6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequences

Sequence LengthMass (Da)Tools
Q6GMX6 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: B3A9B7D0FDB1386E

FASTA46551,083
        10         20         30         40         50         60 
MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGGSISG YYWSWIRQPA 

        70         80         90        100        110        120 
GKGLEWIGRI YTSGSTNYNP SLKSRVTMSV DTSKNQFSLK LSSVTAADTA VYYCARGRFT 

       130        140        150        160        170        180 
YFDYWGQGTL VTVSSASTKG PSVFPLAPSS KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA 

       190        200        210        220        230        240 
LTSGVHTFPA VLQSSGLYSL SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK 

       250        260        270        280        290        300 
THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV 

       310        320        330        340        350        360 
EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ 

       370        380        390        400        410        420 
PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG 

       430        440        450        460 
SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK 

« Hide

References

« Hide 'large scale' references
[1]"Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart."
Cheetham G.M., Hale G., Waldmann H., Bloomer A.C.
J. Mol. Biol. 284:85-99(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 20-233.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Primary B-Cells EMBL AAH73766.1.
[3]"The structure of an antitumor C(H)2-domain-deleted humanized antibody."
Larson S.B., Day J.S., Glaser S., Braslawsky G., McPherson A.
J. Mol. Biol. 348:1177-1190(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 124-465.
[4]"A potent erythropoietin-mimicking human antibody interacts through a novel binding site."
Liu Z., Stoll V.S., Devries P.J., Jakob C.G., Xie N., Simmer R.L., Lacy S.E., Egan D.A., Harlan J.E., Lesniewski R.R., Reilly E.B.
Blood 110:2408-2413(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 20-236.
[5]"Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site."
Julien J.P., Bryson S., Nieva J.L., Pai E.F.
J. Mol. Biol. 384:377-392(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 55-240.
[6]"Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8."
Li S., Kussie P., Ferguson K.M.
Structure 16:216-227(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 20-237.
[7]"Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies."
Mouquet H., Scharf L., Euler Z., Liu Y., Eden C., Scheid J.F., Halper-Stromberg A., Gnanapragasam P.N., Spencer D.I., Seaman M.S., Schuitemaker H., Feizi T., Nussenzweig M.C., Bjorkman P.J.
Proc. Natl. Acad. Sci. U.S.A. 109:E3268-E3277(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 20-242.
[8]"Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals."
Gorny M.K., Pan R., Williams C., Wang X.H., Volsky B., O'Neal T., Spurrier B., Sampson J.M., Li L., Seaman M.S., Kong X.P., Zolla-Pazner S.
Virology 427:198-207(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 119-237.
[9]"The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies."
Sok D., Laserson U., Laserson J., Liu Y., Vigneault F., Julien J.P., Briney B., Ramos A., Saye K.F., Le K., Mahan A., Wang S., Kardar M., Yaari G., Walker L.M., Simen B.B., St John E.P., Chan-Hui P.Y. expand/collapse author list , Swiderek K., Kleinstein S.H., Kleinstein S.H., Alter G., Seaman M.S., Chakraborty A.K., Koller D., Wilson I.A., Church G.M., Burton D.R., Poignard P.
PLoS Pathog. 9:e1003754-e1003754(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 21-238.
[10]"Antibody Structural Organization:Role of Kappa - Lambda Chain Constant Domain Switch in Catalytic Functionality."
Ponomarenko N.A., Chatziefthimiou S.D., Kurkova I.N., Mokrushina Y.A., Stepanova A.V., Smirnov I.V., Avakyan E.M., Bobik T.V., Mamedov A., Mitkevich V.A., Belogurov A.J., Fedorova O.S., Dubina M., Lamzin V.S., Friboulet A., Makarov A.A., Wilmanns M., Gabibov A.G.
Submitted (JAN-2013) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 20-238.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC073766 mRNA. Translation: AAH73766.1.
UniGeneHs.510635.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BEYX-ray3.25H20-233[»]
1ZA6X-ray2.80B/D/F/H124-465[»]
2JIXX-ray3.20D/F/H20-236[»]
3B2VX-ray3.30H20-237[»]
3D0LX-ray2.35B55-240[»]
3ZL4X-ray1.95H20-238[»]
4D9LX-ray2.48H/I/J/K119-237[»]
4FQQX-ray2.42B/D/F/H20-242[»]
4LKXX-ray1.92A20-243[»]
4NPYX-ray1.80B/H21-238[»]
ProteinModelPortalQ6GMX6.
SMRQ6GMX6. Positions 23-462.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6GMX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005814.

Gene expression databases

ArrayExpressQ6GMX6.
BgeeQ6GMX6.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07654. C1-set. 3 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ6GMX6.

Entry information

Entry nameQ6GMX6_HUMAN
AccessionPrimary (citable) accession number: Q6GMX6
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.