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Q6GMX6

- Q6GMX6_HUMAN

UniProt

Q6GMX6 - Q6GMX6_HUMAN

Protein
Submitted name:

IGH@ protein

Gene

IGH@

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Submitted name:
    IGH@ proteinImported
    Gene namesi
    Name:IGH@Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6GMX6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6GMX6.
    BgeeiQ6GMX6.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BEYX-ray3.25H20-233[»]
    1ZA6X-ray2.80B/D/F/H124-465[»]
    2JIXX-ray3.20D/F/H20-236[»]
    3B2UX-ray2.58C/F/H/J/N/Q/T/W20-237[»]
    3B2VX-ray3.30H20-237[»]
    3D0LX-ray2.35B55-240[»]
    3ZL4X-ray1.95H20-238[»]
    4D9LX-ray2.48H/I/J/K119-237[»]
    4FQQX-ray2.42B/D/F/H20-242[»]
    4LKXX-ray1.92A20-243[»]
    4NPYX-ray1.80B/H21-238[»]
    4QHKX-ray3.49I/K/M/O20-242[»]
    4QHLX-ray3.15A/C20-242[»]
    4QHMX-ray3.23A/C/E/G20-242[»]
    4QHNX-ray3.00A20-242[»]
    ProteinModelPortaliQ6GMX6.
    SMRiQ6GMX6. Positions 23-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6GMX6.

    Family & Domainsi

    Keywords - Domaini

    Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG005814.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07654. C1-set. 3 hits.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 2 hits.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    PS00290. IG_MHC. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GMX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGGSISG    50
    YYWSWIRQPA GKGLEWIGRI YTSGSTNYNP SLKSRVTMSV DTSKNQFSLK 100
    LSSVTAADTA VYYCARGRFT YFDYWGQGTL VTVSSASTKG PSVFPLAPSS 150
    KSTSGGTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL 200
    SSVVTVPSSS LGTQTYICNV NHKPSNTKVD KKVEPKSCDK THTCPPCPAP 250
    ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV 300
    EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI 350
    EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE 400
    SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL 450
    HNHYTQKSLS LSPGK 465
    Length:465
    Mass (Da):51,083
    Last modified:July 19, 2004 - v1
    Checksum:iB3A9B7D0FDB1386E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC073766 mRNA. Translation: AAH73766.1.
    UniGeneiHs.510635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC073766 mRNA. Translation: AAH73766.1 .
    UniGenei Hs.510635.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BEY X-ray 3.25 H 20-233 [» ]
    1ZA6 X-ray 2.80 B/D/F/H 124-465 [» ]
    2JIX X-ray 3.20 D/F/H 20-236 [» ]
    3B2U X-ray 2.58 C/F/H/J/N/Q/T/W 20-237 [» ]
    3B2V X-ray 3.30 H 20-237 [» ]
    3D0L X-ray 2.35 B 55-240 [» ]
    3ZL4 X-ray 1.95 H 20-238 [» ]
    4D9L X-ray 2.48 H/I/J/K 119-237 [» ]
    4FQQ X-ray 2.42 B/D/F/H 20-242 [» ]
    4LKX X-ray 1.92 A 20-243 [» ]
    4NPY X-ray 1.80 B/H 21-238 [» ]
    4QHK X-ray 3.49 I/K/M/O 20-242 [» ]
    4QHL X-ray 3.15 A/C 20-242 [» ]
    4QHM X-ray 3.23 A/C/E/G 20-242 [» ]
    4QHN X-ray 3.00 A 20-242 [» ]
    ProteinModelPortali Q6GMX6.
    SMRi Q6GMX6. Positions 23-462.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6GMX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005814.

    Miscellaneous databases

    EvolutionaryTracei Q6GMX6.

    Gene expression databases

    ArrayExpressi Q6GMX6.
    Bgeei Q6GMX6.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07654. C1-set. 3 hits.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 2 hits.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    PS00290. IG_MHC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart."
      Cheetham G.M., Hale G., Waldmann H., Bloomer A.C.
      J. Mol. Biol. 284:85-99(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 20-233.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Primary B-CellsImported.
    3. "The structure of an antitumor C(H)2-domain-deleted humanized antibody."
      Larson S.B., Day J.S., Glaser S., Braslawsky G., McPherson A.
      J. Mol. Biol. 348:1177-1190(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 124-465.
    4. "A potent erythropoietin-mimicking human antibody interacts through a novel binding site."
      Liu Z., Stoll V.S., Devries P.J., Jakob C.G., Xie N., Simmer R.L., Lacy S.E., Egan D.A., Harlan J.E., Lesniewski R.R., Reilly E.B.
      Blood 110:2408-2413(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 20-236.
    5. "Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site."
      Julien J.P., Bryson S., Nieva J.L., Pai E.F.
      J. Mol. Biol. 384:377-392(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 55-240.
    6. "Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8."
      Li S., Kussie P., Ferguson K.M.
      Structure 16:216-227(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.58 ANGSTROMS) OF 20-237.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 20-242.
    8. "Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals."
      Gorny M.K., Pan R., Williams C., Wang X.H., Volsky B., O'Neal T., Spurrier B., Sampson J.M., Li L., Seaman M.S., Kong X.P., Zolla-Pazner S.
      Virology 427:198-207(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 119-237.
    9. "The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies."
      Sok D., Laserson U., Laserson J., Liu Y., Vigneault F., Julien J.P., Briney B., Ramos A., Saye K.F., Le K., Mahan A., Wang S., Kardar M., Yaari G., Walker L.M., Simen B.B., St John E.P., Chan-Hui P.Y.
      , Swiderek K., Kleinstein S.H., Kleinstein S.H., Alter G., Seaman M.S., Chakraborty A.K., Koller D., Wilson I.A., Church G.M., Burton D.R., Poignard P.
      PLoS Pathog. 9:e1003754-e1003754(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 21-238.
    10. "Role of ??? light-chain constant-domain switch in the structure and functionality of A17 reactibody."
      Ponomarenko N., Chatziefthimiou S.D., Kurkova I., Mokrushina Y., Mokrushina Y., Stepanova A., Smirnov I., Avakyan M., Bobik T., Mamedov A., Mitkevich V., Belogurov A., Fedorova O.S., Dubina M., Golovin A., Lamzin V., Friboulet A., Makarov A.A., Wilmanns M., Gabibov A.
      Acta Crystallogr. D 70:708-719(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 20-238.
    11. "Antibody Affinity Maturation in an HIV Broadly Neutralizing B-cell Lineage: a Shift in Relative Orientation of Light- and Heavy-Chain Variable Domains."
      Fera D., Schmidt A.G., Haynes B.F., Gao F., Liao H.X., Kepler T.B., Harrison S.C.
      Submitted (MAY-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 20-242.

    Entry informationi

    Entry nameiQ6GMX6_HUMAN
    AccessioniPrimary (citable) accession number: Q6GMX6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3