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Protein

Putative peptidyl-tRNA hydrolase PTRHD1

Gene

PTRHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:G66-32508-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptidyl-tRNA hydrolase PTRHD1 (EC:3.1.1.29)
Alternative name(s):
Peptidyl-tRNA hydrolase domain-containing protein 1
Gene namesi
Name:PTRHD1
Synonyms:C2orf79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33782. PTRHD1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184924.
PharmGKBiPA162379611.

Polymorphism and mutation databases

BioMutaiPTRHD1.
DMDMi74736452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003218181 – 140Putative peptidyl-tRNA hydrolase PTRHD1Add BLAST140

Proteomic databases

EPDiQ6GMV3.
MaxQBiQ6GMV3.
PaxDbiQ6GMV3.
PeptideAtlasiQ6GMV3.
PRIDEiQ6GMV3.
TopDownProteomicsiQ6GMV3.

PTM databases

iPTMnetiQ6GMV3.
PhosphoSitePlusiQ6GMV3.

Expressioni

Gene expression databases

BgeeiENSG00000184924.
CleanExiHS_C2orf79.
GenevisibleiQ6GMV3. HS.

Organism-specific databases

HPAiHPA019951.

Interactioni

Protein-protein interaction databases

BioGridi133896. 6 interactors.
MINTiMINT-5003206.
STRINGi9606.ENSP00000330389.

Structurei

3D structure databases

ProteinModelPortaliQ6GMV3.
SMRiQ6GMV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family. PTRHD1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3305. Eukaryota.
ENOG4111N6W. LUCA.
GeneTreeiENSGT00500000044959.
HOVERGENiHBG057768.
InParanoidiQ6GMV3.
OMAiPHTVAYL.
OrthoDBiEOG091G0X3B.
PhylomeDBiQ6GMV3.
TreeFamiTF353726.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GMV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRGVGPAFR VVRKMAASGA EPQVLVQYLV LRKDLSQAPF SWPAGALVAQ
60 70 80 90 100
ACHAATAALH THRDHPHTAA YLQELGRMRK VVLEAPDETT LKELAETLQQ
110 120 130 140
KNIDHMLWLE QPENIATCIA LRPYPKEEVG QYLKKFRLFK
Length:140
Mass (Da):15,805
Last modified:July 19, 2004 - v1
Checksum:i3AD1C82F3A9CF80B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAX00745.1.
BC073803 mRNA. Translation: AAH73803.1.
CCDSiCCDS33156.1.
RefSeqiNP_001013685.1. NM_001013663.1.
UniGeneiHs.406607.

Genome annotation databases

EnsembliENST00000328379; ENSP00000330389; ENSG00000184924.
GeneIDi391356.
KEGGihsa:391356.
UCSCiuc002rfm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAX00745.1.
BC073803 mRNA. Translation: AAH73803.1.
CCDSiCCDS33156.1.
RefSeqiNP_001013685.1. NM_001013663.1.
UniGeneiHs.406607.

3D structure databases

ProteinModelPortaliQ6GMV3.
SMRiQ6GMV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133896. 6 interactors.
MINTiMINT-5003206.
STRINGi9606.ENSP00000330389.

PTM databases

iPTMnetiQ6GMV3.
PhosphoSitePlusiQ6GMV3.

Polymorphism and mutation databases

BioMutaiPTRHD1.
DMDMi74736452.

Proteomic databases

EPDiQ6GMV3.
MaxQBiQ6GMV3.
PaxDbiQ6GMV3.
PeptideAtlasiQ6GMV3.
PRIDEiQ6GMV3.
TopDownProteomicsiQ6GMV3.

Protocols and materials databases

DNASUi391356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328379; ENSP00000330389; ENSG00000184924.
GeneIDi391356.
KEGGihsa:391356.
UCSCiuc002rfm.4. human.

Organism-specific databases

CTDi391356.
GeneCardsiPTRHD1.
HGNCiHGNC:33782. PTRHD1.
HPAiHPA019951.
neXtProtiNX_Q6GMV3.
OpenTargetsiENSG00000184924.
PharmGKBiPA162379611.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3305. Eukaryota.
ENOG4111N6W. LUCA.
GeneTreeiENSGT00500000044959.
HOVERGENiHBG057768.
InParanoidiQ6GMV3.
OMAiPHTVAYL.
OrthoDBiEOG091G0X3B.
PhylomeDBiQ6GMV3.
TreeFamiTF353726.

Enzyme and pathway databases

BioCyciZFISH:G66-32508-MONOMER.

Miscellaneous databases

GenomeRNAii391356.
PROiQ6GMV3.

Gene expression databases

BgeeiENSG00000184924.
CleanExiHS_C2orf79.
GenevisibleiQ6GMV3. HS.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTRD1_HUMAN
AccessioniPrimary (citable) accession number: Q6GMV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.