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Protein

Putative peptidyl-tRNA hydrolase PTRHD1

Gene

PTRHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptidyl-tRNA hydrolase PTRHD1 (EC:3.1.1.29)
Alternative name(s):
Peptidyl-tRNA hydrolase domain-containing protein 1
Gene namesi
Name:PTRHD1
Synonyms:C2orf79
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000184924.5
HGNCiHGNC:33782 PTRHD1
MIMi617342 gene
neXtProtiNX_Q6GMV3

Pathology & Biotechi

Organism-specific databases

DisGeNETi391356
OpenTargetsiENSG00000184924
PharmGKBiPA162379611

Polymorphism and mutation databases

BioMutaiPTRHD1
DMDMi74736452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003218181 – 140Putative peptidyl-tRNA hydrolase PTRHD1Add BLAST140

Proteomic databases

EPDiQ6GMV3
MaxQBiQ6GMV3
PaxDbiQ6GMV3
PeptideAtlasiQ6GMV3
PRIDEiQ6GMV3
TopDownProteomicsiQ6GMV3

PTM databases

iPTMnetiQ6GMV3
PhosphoSitePlusiQ6GMV3

Expressioni

Gene expression databases

BgeeiENSG00000184924
CleanExiHS_C2orf79
GenevisibleiQ6GMV3 HS

Organism-specific databases

HPAiHPA019951

Interactioni

Protein-protein interaction databases

BioGridi133896, 8 interactors
IntActiQ6GMV3, 2 interactors
STRINGi9606.ENSP00000330389

Structurei

3D structure databases

ProteinModelPortaliQ6GMV3
SMRiQ6GMV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family. PTRHD1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3305 Eukaryota
ENOG4111N6W LUCA
GeneTreeiENSGT00500000044959
HOVERGENiHBG057768
InParanoidiQ6GMV3
OMAiPQILVQY
OrthoDBiEOG091G0X3B
PhylomeDBiQ6GMV3
TreeFamiTF353726

Family and domain databases

Gene3Di3.40.1490.10, 1 hit
InterProiView protein in InterPro
IPR023476 Pep_tRNA_hydro_II_dom_sf
IPR002833 PTH2
PfamiView protein in Pfam
PF01981 PTH2, 1 hit
SUPFAMiSSF102462 SSF102462, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GMV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRGVGPAFR VVRKMAASGA EPQVLVQYLV LRKDLSQAPF SWPAGALVAQ
60 70 80 90 100
ACHAATAALH THRDHPHTAA YLQELGRMRK VVLEAPDETT LKELAETLQQ
110 120 130 140
KNIDHMLWLE QPENIATCIA LRPYPKEEVG QYLKKFRLFK
Length:140
Mass (Da):15,805
Last modified:July 19, 2004 - v1
Checksum:i3AD1C82F3A9CF80B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07854752C → Y Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs781442277EnsemblClinVar.1
Natural variantiVAR_07854853H → Y Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA Translation: EAX00745.1
BC073803 mRNA Translation: AAH73803.1
CCDSiCCDS33156.1
RefSeqiNP_001013685.1, NM_001013663.1
UniGeneiHs.406607

Genome annotation databases

EnsembliENST00000328379; ENSP00000330389; ENSG00000184924
GeneIDi391356
KEGGihsa:391356
UCSCiuc002rfm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTRD1_HUMAN
AccessioniPrimary (citable) accession number: Q6GMV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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