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Protein

SET and MYND domain-containing protein 5

Gene

SMYD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri98 – 13639MYND-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SET and MYND domain-containing protein 5 (EC:2.1.1.-)
Alternative name(s):
Protein NN8-4AG
Retinoic acid-induced protein 15
Gene namesi
Name:SMYD5
Synonyms:RAI15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16258. SMYD5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34190.

Polymorphism and mutation databases

BioMutaiSMYD5.
DMDMi90101758.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418SET and MYND domain-containing protein 5PRO_0000227788Add
BLAST

Proteomic databases

EPDiQ6GMV2.
MaxQBiQ6GMV2.
PaxDbiQ6GMV2.
PRIDEiQ6GMV2.

PTM databases

iPTMnetiQ6GMV2.
PhosphoSiteiQ6GMV2.

Expressioni

Gene expression databases

BgeeiQ6GMV2.
CleanExiHS_SMYD5.
ExpressionAtlasiQ6GMV2. baseline and differential.
GenevisibleiQ6GMV2. HS.

Organism-specific databases

HPAiHPA015514.
HPA049002.

Interactioni

Protein-protein interaction databases

BioGridi115606. 4 interactions.
IntActiQ6GMV2. 2 interactions.
STRINGi9606.ENSP00000374152.

Structurei

3D structure databases

ProteinModelPortaliQ6GMV2.
SMRiQ6GMV2. Positions 26-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 352332SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 2034Poly-Glu
Compositional biasi384 – 41431Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 MYND-type zinc finger.Curated
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri98 – 13639MYND-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00510000047420.
HOGENOMiHOG000007877.
HOVERGENiHBG060385.
InParanoidiQ6GMV2.
OMAiRYCSEDC.
PhylomeDBiQ6GMV2.
TreeFamiTF106419.

Family and domain databases

InterProiIPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GMV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASMCDVFS FCVGVAGRAR VSVEVRFVSS AKGKGLFATQ LIRKGETIFV
60 70 80 90 100
ERPLVAAQFL WNALYRYRAC DHCLRALEKA EENAQRLTGK PGQVLPHPEL
110 120 130 140 150
CTVRKDLHQN CPHCQVMYCS AECRLAATEQ YHQVLCPGPS QDDPLHPLNK
160 170 180 190 200
LQEAWRSIHY PPETASIMLM ARMVATVKQA KDKDRWIRLF SQFCNKTANE
210 220 230 240 250
EEEIVHKLLG DKFKGQLELL RRLFTEALYE EAVSQWFTPD GFRSLFALVG
260 270 280 290 300
TNGQGIGTSS LSQWVHACDT LELKPQDREQ LDAFIDQLYK DIEAATGEFL
310 320 330 340 350
NCEGSGLFVL QSCCNHSCVP NAETSFPENN FLLHVTALED IKPGEEICIS
360 370 380 390 400
YLDCCQRERS RHSRHKILRE NYLFVCSCPK CLAEADEPNV TSEEEEEEEE
410
EEEGEPEDAE LGDEMTDV
Length:418
Mass (Da):47,341
Last modified:March 21, 2006 - v2
Checksum:i11073818FF5EEB83
GO

Sequence cautioni

The sequence AAH73806.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71D → A in AAB38131 (PubMed:8754834).Curated
Sequence conflicti280 – 2812QL → HV in AAB38131 (PubMed:8754834).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAW99744.1.
CH471053 Genomic DNA. Translation: EAW99745.1.
BC073806 mRNA. Translation: AAH73806.1. Different initiation.
U50383 mRNA. Translation: AAB38131.1.
CCDSiCCDS33221.2.
PIRiG02453.
RefSeqiNP_006053.2. NM_006062.2.
UniGeneiHs.631882.

Genome annotation databases

EnsembliENST00000389501; ENSP00000374152; ENSG00000135632.
GeneIDi10322.
KEGGihsa:10322.
UCSCiuc002siw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAW99744.1.
CH471053 Genomic DNA. Translation: EAW99745.1.
BC073806 mRNA. Translation: AAH73806.1. Different initiation.
U50383 mRNA. Translation: AAB38131.1.
CCDSiCCDS33221.2.
PIRiG02453.
RefSeqiNP_006053.2. NM_006062.2.
UniGeneiHs.631882.

3D structure databases

ProteinModelPortaliQ6GMV2.
SMRiQ6GMV2. Positions 26-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115606. 4 interactions.
IntActiQ6GMV2. 2 interactions.
STRINGi9606.ENSP00000374152.

PTM databases

iPTMnetiQ6GMV2.
PhosphoSiteiQ6GMV2.

Polymorphism and mutation databases

BioMutaiSMYD5.
DMDMi90101758.

Proteomic databases

EPDiQ6GMV2.
MaxQBiQ6GMV2.
PaxDbiQ6GMV2.
PRIDEiQ6GMV2.

Protocols and materials databases

DNASUi10322.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389501; ENSP00000374152; ENSG00000135632.
GeneIDi10322.
KEGGihsa:10322.
UCSCiuc002siw.3. human.

Organism-specific databases

CTDi10322.
GeneCardsiSMYD5.
HGNCiHGNC:16258. SMYD5.
HPAiHPA015514.
HPA049002.
neXtProtiNX_Q6GMV2.
PharmGKBiPA34190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2084. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00510000047420.
HOGENOMiHOG000007877.
HOVERGENiHBG060385.
InParanoidiQ6GMV2.
OMAiRYCSEDC.
PhylomeDBiQ6GMV2.
TreeFamiTF106419.

Miscellaneous databases

ChiTaRSiSMYD5. human.
GenomeRNAii10322.
PROiQ6GMV2.

Gene expression databases

BgeeiQ6GMV2.
CleanExiHS_SMYD5.
ExpressionAtlasiQ6GMV2. baseline and differential.
GenevisibleiQ6GMV2. HS.

Family and domain databases

InterProiIPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA."
    Shago M., Giguere V.
    Mol. Cell. Biol. 16:4337-4348(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-418.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMYD5_HUMAN
AccessioniPrimary (citable) accession number: Q6GMV2
Secondary accession number(s): D6W5H3, Q13558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.