Q6GMV1 (ALG1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glycosyltransferase ALG1-like
EC=2.4.1.-

Gene names

Name:

ALG1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative glycosyltransferase By similarity.
Sequence similarities	Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Putative glycosyltransferase ALG1-like		PRO_0000326037
Natural variations
	Natural variant	135	1	N → D. Ref.3 Corresponds to variant rs3828357 [ dbSNP | Ensembl ].		VAR_039962
	Natural variant	159	1	I → T. Corresponds to variant rs3811679 [ dbSNP | Ensembl ].		VAR_039963
	Natural variant	184	1	G → S. Corresponds to variant rs3187686 [ dbSNP | Ensembl ].		VAR_039964

Sequences

	Sequence		Length	Mass (Da)
	Q6GMV1 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: D8346DBD88A66CCF	FASTA	187	21,132
	10 20 30 40 50 60 MERSAFMELD AGSRLVMHLR EWPALLVSST GWTEFEQLTL DGHNLPSLVC VITGSVDLGV 70 80 90 100 110 120 CLHMSSSGLD LPMKVVDMFG CCLPVCAVNF KCLHELVKHE ENGLVFEDSE ELAALQMLFS 130 140 150 160 170 180 NFPDPAGKLN QFWKNLRESQ QLRWDESWVQ TVLPLVMDIQ LLGQRLKPRD PCCPSRSFFS ESQGKPF

References

[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-135. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471052 Genomic DNA. Translation: EAW79378.1. CH471052 Genomic DNA. Translation: EAW79380.1. BC073816 mRNA. Translation: AAH73816.1.
IPI	IPI00145612.
RefSeq	NP_001015050.2. NM_001015050.2. NP_001182152.1. NM_001195223.1.
UniGene	Hs.591299.
3D structure databases
ProteinModelPortal	Q6GMV1.
SMR	Q6GMV1. Positions 55-122.
ModBase	Search...
Protein family/group databases
CAZy	GT33. Glycosyltransferase Family 33.
Polymorphism databases
DMDM	269849540.
Proteomic databases
PaxDb	Q6GMV1.
PRIDE	Q6GMV1.
Protocols and materials databases
DNASU	200810.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340333; ENSP00000340009; ENSG00000189366.
GeneID	200810.
KEGG	hsa:200810.
UCSC	uc003eig.2. human.
Organism-specific databases
CTD	200810.
GeneCards	GC03M125648.
HGNC	HGNC:33721. ALG1L.
HPA	HPA036108.
neXtProt	NX_Q6GMV1.
PharmGKB	PA165696816.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0438.
HOGENOM	HOG000172312.
InParanoid	Q6GMV1.
OMA	GWTEFEQ.
OrthoDB	EOG4RV2SF.
Gene expression databases
Bgee	Q6GMV1.
Genevestigator	Q6GMV1.
Family and domain databases
InterPro	IPR026051. ALG1-like. [Graphical view]
PANTHER	PTHR13036. PTHR13036. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	200810.
NextBio	89978.

Entry information

Entry name

ALG1L_HUMAN

Accession

Primary (citable) accession number: Q6GMV1
Secondary accession number(s): D3DNA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.