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Protein

Fatty-acid amide hydrolase 2

Gene

FAAH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.1 Publication

Catalytic activityi

Anandamide + H2O = arachidonic acid + ethanolamine.
Oleamide + H2O = oleic acid + NH3.

Enzyme regulationi

Inhibited by O-aryl carbamates and alpha-keto heterocytes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1
Active sitei230Acyl-ester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS09254-MONOMER.
BRENDAi3.5.1.4. 2681.
3.5.1.99. 2681.
ReactomeiR-HSA-2142753. Arachidonic acid metabolism.

Chemistry databases

SwissLipidsiSLP:000001059.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty-acid amide hydrolase 2 (EC:3.5.1.99)
Alternative name(s):
Amidase domain-containing protein
Anandamide amidohydrolase 2
Oleamide hydrolase 2
Gene namesi
Name:FAAH2
Synonyms:AMDD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:26440. FAAH2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi158584.
OpenTargetsiENSG00000165591.
PharmGKBiPA162385543.

Chemistry databases

ChEMBLiCHEMBL1628475.
GuidetoPHARMACOLOGYi1401.

Polymorphism and mutation databases

BioMutaiFAAH2.
DMDMi74757585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002919931 – 532Fatty-acid amide hydrolase 2Add BLAST532

Proteomic databases

MaxQBiQ6GMR7.
PaxDbiQ6GMR7.
PeptideAtlasiQ6GMR7.
PRIDEiQ6GMR7.

PTM databases

iPTMnetiQ6GMR7.
PhosphoSitePlusiQ6GMR7.

Expressioni

Tissue specificityi

Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate.1 Publication

Gene expression databases

BgeeiENSG00000165591.
CleanExiHS_FAAH2.
ExpressionAtlasiQ6GMR7. baseline and differential.
GenevisibleiQ6GMR7. HS.

Organism-specific databases

HPAiHPA027534.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi127693. 1 interactor.
STRINGi9606.ENSP00000364035.

Chemistry databases

BindingDBiQ6GMR7.

Structurei

3D structure databases

ProteinModelPortaliQ6GMR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 51Poly-Leu4

Sequence similaritiesi

Belongs to the amidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1212. Eukaryota.
COG0154. LUCA.
GeneTreeiENSGT00550000074673.
HOGENOMiHOG000116697.
HOVERGENiHBG101001.
InParanoidiQ6GMR7.
KOiK19176.
OMAiHKPTTGV.
OrthoDBiEOG091G07DM.
PhylomeDBiQ6GMR7.
TreeFamiTF313781.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GMR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSFTARIQ LFLLRALGFL IGLVGRAALV LGGPKFASKT PRPVTEPLLL
60 70 80 90 100
LSGMQLAKLI RQRKVKCIDV VQAYINRIKD VNPMINGIVK YRFEEAMKEA
110 120 130 140 150
HAVDQKLAEK QEDEATLENK WPFLGVPLTV KEAFQLQGMP NSSGLMNRRD
160 170 180 190 200
AIAKTDATVV ALLKGAGAIP LGITNCSELC MWYESSNKIY GRSNNPYDLQ
210 220 230 240 250
HIVGGSSGGE GCTLAAACSV IGVGSDIGGS IRMPAFFNGI FGHKPSPGVV
260 270 280 290 300
PNKGQFPLAV GAQELFLCTG PMCRYAEDLA PMLKVMAGPG IKRLKLDTKV
310 320 330 340 350
HLKDLKFYWM EHDGGSFLMS KVDQDLIMTQ KKVVVHLETI LGASVQHVKL
360 370 380 390 400
KKMKYSFQLW IAMMSAKGHD GKEPVKFVDL LGDHGKHVSP LWELIKWCLG
410 420 430 440 450
LSVYTIPSIG LALLEEKLRY SNEKYQKFKA VEESLRKELV DMLGDDGVFL
460 470 480 490 500
YPSHPTVAPK HHVPLTRPFN FAYTGVFSAL GLPVTQCPLG LNAKGLPLGI
510 520 530
QVVAGPFNDH LTLAVAQYLE KTFGGWVCPG KF
Length:532
Mass (Da):58,304
Last modified:July 19, 2004 - v1
Checksum:i1D83E34BFF186E5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98K → R in BAB71007 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055766 mRNA. Translation: BAB71007.1.
AL928898
, AL590394, AL606754, Z83745 Genomic DNA. Translation: CAH71179.1.
AL590394
, AL606754, AL928898, Z83745 Genomic DNA. Translation: CAI40731.1.
AL606754
, AL590394, AL928898, Z83745 Genomic DNA. Translation: CAI40852.1.
Z83745
, AL590394, AL606754, AL928898 Genomic DNA. Translation: CAI42802.1.
BC048279 mRNA. Translation: AAH48279.1.
BC073922 mRNA. Translation: AAH73922.1.
CCDSiCCDS14375.1.
RefSeqiNP_777572.2. NM_174912.3.
UniGeneiHs.496205.
Hs.745495.

Genome annotation databases

EnsembliENST00000374900; ENSP00000364035; ENSG00000165591.
GeneIDi158584.
KEGGihsa:158584.
UCSCiuc004dvc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055766 mRNA. Translation: BAB71007.1.
AL928898
, AL590394, AL606754, Z83745 Genomic DNA. Translation: CAH71179.1.
AL590394
, AL606754, AL928898, Z83745 Genomic DNA. Translation: CAI40731.1.
AL606754
, AL590394, AL928898, Z83745 Genomic DNA. Translation: CAI40852.1.
Z83745
, AL590394, AL606754, AL928898 Genomic DNA. Translation: CAI42802.1.
BC048279 mRNA. Translation: AAH48279.1.
BC073922 mRNA. Translation: AAH73922.1.
CCDSiCCDS14375.1.
RefSeqiNP_777572.2. NM_174912.3.
UniGeneiHs.496205.
Hs.745495.

3D structure databases

ProteinModelPortaliQ6GMR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127693. 1 interactor.
STRINGi9606.ENSP00000364035.

Chemistry databases

BindingDBiQ6GMR7.
ChEMBLiCHEMBL1628475.
GuidetoPHARMACOLOGYi1401.
SwissLipidsiSLP:000001059.

PTM databases

iPTMnetiQ6GMR7.
PhosphoSitePlusiQ6GMR7.

Polymorphism and mutation databases

BioMutaiFAAH2.
DMDMi74757585.

Proteomic databases

MaxQBiQ6GMR7.
PaxDbiQ6GMR7.
PeptideAtlasiQ6GMR7.
PRIDEiQ6GMR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374900; ENSP00000364035; ENSG00000165591.
GeneIDi158584.
KEGGihsa:158584.
UCSCiuc004dvc.4. human.

Organism-specific databases

CTDi158584.
DisGeNETi158584.
GeneCardsiFAAH2.
H-InvDBHIX0021688.
HGNCiHGNC:26440. FAAH2.
HPAiHPA027534.
MIMi300654. gene.
neXtProtiNX_Q6GMR7.
OpenTargetsiENSG00000165591.
PharmGKBiPA162385543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1212. Eukaryota.
COG0154. LUCA.
GeneTreeiENSGT00550000074673.
HOGENOMiHOG000116697.
HOVERGENiHBG101001.
InParanoidiQ6GMR7.
KOiK19176.
OMAiHKPTTGV.
OrthoDBiEOG091G07DM.
PhylomeDBiQ6GMR7.
TreeFamiTF313781.

Enzyme and pathway databases

BioCyciZFISH:HS09254-MONOMER.
BRENDAi3.5.1.4. 2681.
3.5.1.99. 2681.
ReactomeiR-HSA-2142753. Arachidonic acid metabolism.

Miscellaneous databases

ChiTaRSiFAAH2. human.
GenomeRNAii158584.
PROiQ6GMR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165591.
CleanExiHS_FAAH2.
ExpressionAtlasiQ6GMR7. baseline and differential.
GenevisibleiQ6GMR7. HS.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAAH2_HUMAN
AccessioniPrimary (citable) accession number: Q6GMR7
Secondary accession number(s): Q86VT2, Q96N98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.