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Q6GMR7

- FAAH2_HUMAN

UniProt

Q6GMR7 - FAAH2_HUMAN

Protein

Fatty-acid amide hydrolase 2

Gene

FAAH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.1 Publication

    Catalytic activityi

    Anandamide + H2O = arachidonic acid + ethanolamine.
    Oleamide + H2O = oleic acid + NH3.

    Enzyme regulationi

    Inhibited by O-aryl carbamates and alpha-keto heterocytes.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Charge relay systemBy similarity
    Active sitei206 – 2061Charge relay systemBy similarity
    Active sitei230 – 2301Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
    2. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty-acid amide hydrolase 2 (EC:3.5.1.99)
    Alternative name(s):
    Amidase domain-containing protein
    Anandamide amidohydrolase 2
    Oleamide hydrolase 2
    Gene namesi
    Name:FAAH2
    Synonyms:AMDD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:26440. FAAH2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162385543.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Fatty-acid amide hydrolase 2PRO_0000291993Add
    BLAST

    Proteomic databases

    MaxQBiQ6GMR7.
    PaxDbiQ6GMR7.
    PRIDEiQ6GMR7.

    PTM databases

    PhosphoSiteiQ6GMR7.

    Expressioni

    Tissue specificityi

    Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate.1 Publication

    Gene expression databases

    ArrayExpressiQ6GMR7.
    BgeeiQ6GMR7.
    CleanExiHS_FAAH2.
    GenevestigatoriQ6GMR7.

    Organism-specific databases

    HPAiHPA027534.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi127693. 1 interaction.
    STRINGi9606.ENSP00000364035.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GMR7.
    SMRiQ6GMR7. Positions 56-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi48 – 514Poly-Leu

    Sequence similaritiesi

    Belongs to the amidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0154.
    HOGENOMiHOG000116697.
    HOVERGENiHBG101001.
    InParanoidiQ6GMR7.
    OMAiEKTFGGW.
    OrthoDBiEOG7PZRX7.
    PhylomeDBiQ6GMR7.
    TreeFamiTF313781.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GMR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSFTARIQ LFLLRALGFL IGLVGRAALV LGGPKFASKT PRPVTEPLLL    50
    LSGMQLAKLI RQRKVKCIDV VQAYINRIKD VNPMINGIVK YRFEEAMKEA 100
    HAVDQKLAEK QEDEATLENK WPFLGVPLTV KEAFQLQGMP NSSGLMNRRD 150
    AIAKTDATVV ALLKGAGAIP LGITNCSELC MWYESSNKIY GRSNNPYDLQ 200
    HIVGGSSGGE GCTLAAACSV IGVGSDIGGS IRMPAFFNGI FGHKPSPGVV 250
    PNKGQFPLAV GAQELFLCTG PMCRYAEDLA PMLKVMAGPG IKRLKLDTKV 300
    HLKDLKFYWM EHDGGSFLMS KVDQDLIMTQ KKVVVHLETI LGASVQHVKL 350
    KKMKYSFQLW IAMMSAKGHD GKEPVKFVDL LGDHGKHVSP LWELIKWCLG 400
    LSVYTIPSIG LALLEEKLRY SNEKYQKFKA VEESLRKELV DMLGDDGVFL 450
    YPSHPTVAPK HHVPLTRPFN FAYTGVFSAL GLPVTQCPLG LNAKGLPLGI 500
    QVVAGPFNDH LTLAVAQYLE KTFGGWVCPG KF 532
    Length:532
    Mass (Da):58,304
    Last modified:July 19, 2004 - v1
    Checksum:i1D83E34BFF186E5E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti98 – 981K → R in BAB71007. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055766 mRNA. Translation: BAB71007.1.
    AL928898
    , AL590394, AL606754, Z83745 Genomic DNA. Translation: CAH71179.1.
    AL590394
    , AL606754, AL928898, Z83745 Genomic DNA. Translation: CAI40731.1.
    AL606754
    , AL590394, AL928898, Z83745 Genomic DNA. Translation: CAI40852.1.
    Z83745
    , AL590394, AL606754, AL928898 Genomic DNA. Translation: CAI42802.1.
    BC048279 mRNA. Translation: AAH48279.1.
    BC073922 mRNA. Translation: AAH73922.1.
    CCDSiCCDS14375.1.
    RefSeqiNP_777572.2. NM_174912.3.
    UniGeneiHs.496205.
    Hs.745495.

    Genome annotation databases

    EnsembliENST00000374900; ENSP00000364035; ENSG00000165591.
    GeneIDi158584.
    KEGGihsa:158584.
    UCSCiuc004dvc.3. human.

    Polymorphism databases

    DMDMi74757585.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055766 mRNA. Translation: BAB71007.1 .
    AL928898
    , AL590394 , AL606754 , Z83745 Genomic DNA. Translation: CAH71179.1 .
    AL590394
    , AL606754 , AL928898 , Z83745 Genomic DNA. Translation: CAI40731.1 .
    AL606754
    , AL590394 , AL928898 , Z83745 Genomic DNA. Translation: CAI40852.1 .
    Z83745
    , AL590394 , AL606754 , AL928898 Genomic DNA. Translation: CAI42802.1 .
    BC048279 mRNA. Translation: AAH48279.1 .
    BC073922 mRNA. Translation: AAH73922.1 .
    CCDSi CCDS14375.1.
    RefSeqi NP_777572.2. NM_174912.3.
    UniGenei Hs.496205.
    Hs.745495.

    3D structure databases

    ProteinModelPortali Q6GMR7.
    SMRi Q6GMR7. Positions 56-524.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127693. 1 interaction.
    STRINGi 9606.ENSP00000364035.

    Chemistry

    ChEMBLi CHEMBL1628475.
    GuidetoPHARMACOLOGYi 1401.

    PTM databases

    PhosphoSitei Q6GMR7.

    Polymorphism databases

    DMDMi 74757585.

    Proteomic databases

    MaxQBi Q6GMR7.
    PaxDbi Q6GMR7.
    PRIDEi Q6GMR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374900 ; ENSP00000364035 ; ENSG00000165591 .
    GeneIDi 158584.
    KEGGi hsa:158584.
    UCSCi uc004dvc.3. human.

    Organism-specific databases

    CTDi 158584.
    GeneCardsi GC0XP057330.
    H-InvDB HIX0021688.
    HGNCi HGNC:26440. FAAH2.
    HPAi HPA027534.
    MIMi 300654. gene.
    neXtProti NX_Q6GMR7.
    PharmGKBi PA162385543.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0154.
    HOGENOMi HOG000116697.
    HOVERGENi HBG101001.
    InParanoidi Q6GMR7.
    OMAi EKTFGGW.
    OrthoDBi EOG7PZRX7.
    PhylomeDBi Q6GMR7.
    TreeFami TF313781.

    Miscellaneous databases

    ChiTaRSi FAAH2. human.
    GenomeRNAii 158584.
    NextBioi 87770.
    PROi Q6GMR7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6GMR7.
    Bgeei Q6GMR7.
    CleanExi HS_FAAH2.
    Genevestigatori Q6GMR7.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "A second fatty acid amide hydrolase with variable distribution among placental mammals."
      Wei B.Q., Mikkelsen T.S., McKinney M.K., Lander E.S., Cravatt B.F.
      J. Biol. Chem. 281:36569-36578(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ENZYME REGULATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFAAH2_HUMAN
    AccessioniPrimary (citable) accession number: Q6GMR7
    Secondary accession number(s): Q86VT2, Q96N98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3