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Reviewed, UniProtKB/Swiss-Prot Q6GML1 (CMAH_DANRE)

Last modified June 16, 2009. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
      Short name=CMP-N-acetylneuraminic acid hydroxylase
    EC=1.14.18.2
Alternative name(s):
    CMP-Neu5Ac hydroxylase
    CMP-NeuAc hydroxylase
    CMP-N-acetylneuraminate monooxygenase
Gene names
Name: cmah
ORF Names: zgc:92407
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

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Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells By similarity.

Catalytic activity

CMP-N-acetylneuraminate + 2 ferrocytochrome b5 + O2 + 2 H+ = CMP-N-glycoloylneuraminate + 2 ferricytochrome b5 + H2O.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Pathway

Amino-sugar metabolism; N-acetylneuraminic acid metabolism.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the CMP-Neu5Ac hydroxylase family.

Contains 1 Rieske domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
PRO_0000127808

Regions

Domain12 – 11099Rieske

Sites

Metal binding521Iron-sulfur (2Fe-2S) By similarity
Metal binding541Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Metal binding731Iron-sulfur (2Fe-2S) By similarity
Metal binding761Iron-sulfur (2Fe-2S); via pros nitrogen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6GML1-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 9462314CEF46A49E

FASTA59168,297
        10         20         30         40         50         60 
MAAQVSHTVL RLEAEDVRNL KDGINFQKNN KDGKCYIIYK ANGELRACRN QCKHQGGLFI 

        70         80         90        100        110        120 
KDIEDMDGRT VRCTKHYWKL NVATMQYVNP PDSFMQDELE AVLSETDGSL ELLELNPPDP 

       130        140        150        160        170        180 
WTAEPREAQD LQAGEITLTY ITHACMELKA GERRMMFDPW LTGPAFARGW WLLHEPPKDA 

       190        200        210        220        230        240 
MDRLMEADLV YISHMHSDHL SYPTLQHLSK KRPDIPIYVG NTSRPVFWYL EKSGVNLTNI 

       250        260        270        280        290        300 
NVVPFGVWQN VDDHLRFMIL MDGVHPEMDT CLIVEYKGHM ILNTVDCTRP NNGRLPHGVD 

       310        320        330        340        350        360 
VMMSDFAGGA SGFPMTFHGG KYTESWKANF IKNERKKLLN YKAQLVKSLQ PKIYCPFAGY 

       370        380        390        400        410        420 
FTEAHPSDRY IKETNTKNSP AELNELIRKS CLNTLTWTPL PGSVLDLAVA LNNRSNETAI 

       430        440        450        460        470        480 
TDPPHGTKIY KDNWEFDLYL NQLNASISAE IFKHKHWIQY YYNWAGFRNY NLVIRVIETD 

       490        500        510        520        530        540 
DDFQPLNGGF DYLVDFLDLS FPTERPEREH AYEEIKNRVN VMRHVVVNGL LWDDLYIGFN 

       550        560        570        580        590 
NRMSRDPDVY HHKFWNHFQT ELPLSAPDWQ HFLQICSQTQ ENGSSNGCSV S

« Hide

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References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

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Cross-references

Sequence databases

BC074033 mRNA. Translation: AAH74033.1.
IPIIPI00511076.
RefSeqNP_001002192.1.
UniGeneDr.82548

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ6GML1.

Genome annotation databases

EnsemblENSDARG00000057714. Danio rerio. [Contig view]
ENSDARG00000074972. Danio rerio. [Contig view]
GeneID431739.
KEGGdre:431739.

Organism-specific databases

ZFINZDB-GENE-040704-33. zgc:92407.

Phylogenomic databases

HOVERGENQ6GML1.

Enzyme and pathway databases

BRENDA1.14.18.2. 96826.

Gene expression databases

BgeeQ6GML1.

Family and domain databases

InterProIPR017941. Rieske_2Fe-2S.
[Graphical view]
PfamPF00355. Rieske. 1 hit.
[Graphical view]
PROSITEPS51296. RIESKE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCMAH_DANRE
AccessionPrimary (citable) accession number: Q6GML1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 19, 2004
Last modified: June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents