Q6GMK8 (GMPAA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase alpha-A
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase A-A
GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A

Gene names

Name:	gmppaa
ORF Names:	zgc:91853

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Mannose-1-phosphate guanyltransferase alpha-A		PRO_0000327876

Sequences

	Sequence		Length	Mass (Da)
	Q6GMK8 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 7A7986D2599C7E4C	FASTA	422	47,011
	10 20 30 40 50 60 MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMLQHH IEACSKLPNM KEILLIGFYQ 70 80 90 100 110 120 PNEELNRFLS CAQQDFKISI RYLQEYAALG TGGGIYHFRD QILSGGPDAF FVMNADVCSE 130 140 150 160 170 180 FPLPEMLDFQ KEHGDTYSFV ILGTTANRKQ SLNYGCIVEN EQTDEVLHYV EKPGTFVSDI 190 200 210 220 230 240 INCGIYLFTP EIFQHIGSVF QKNQQEMLLE EQSNGWHRAE VIRLEQDIFT ALAGQGKLYV 250 260 270 280 290 300 YKTDRFWSQI KSAGSAIYAS RLYLNQYHKT HPERLATNTE GGAKTRGNVY IHPTANIDPT 310 320 330 340 350 360 AVLGPNVSIG TGVTIGAGVR VRESIILHGA TLQDHSCVLN SIVGWESTIG KWARVEGTPS 370 380 390 400 410 420 DPNPNDPYAK IDSETLFRDG KLTPSITILG CNVNIPSEVI ILNSIVLPHK DLNRSFKNQI IL

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074036 mRNA. Translation: AAH74036.1.
IPI	IPI00493357.
RefSeq	NP_001002196.1. NM_001002196.1.
UniGene	Dr.83481.
3D structure databases
HSSP	HSSP built from PDB template 1J2Z based on UniProtKB O25927.
ProteinModelPortal	Q6GMK8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GMK8.
Proteomic databases
PRIDE	Q6GMK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000003543; ENSDARP00000017348; ENSDARG00000024112.
GeneID	431743.
KEGG	dre:431743.
NMPDR	fig|7955.3.peg.23232.
Organism-specific databases
CTD	431743.
ZFIN	ZDB-GENE-040704-37. gmppaa.
Phylogenomic databases
eggNOG	fiNOG04657.
GeneTree	ENSGT00530000063581.
HOVERGEN	HBG059531.
InParanoid	Q6GMK8.
OMA	PFAKMDN.
OrthoDB	EOG4SXNCG.
PhylomeDB	Q6GMK8.
Gene expression databases
ArrayExpress	Q6GMK8.
Bgee	Q6GMK8.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPAA_DANRE

Accession

Primary (citable) accession number: Q6GMK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	July 19, 2004
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program