Q6GMK2 (Q6GMK2_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase EMBL AAH74043.1

Submitted name:
Mthfd2 protein EMBL AAI55263.1
Submitted name:
Uncharacterized protein Ensembl ENSDARP00000043919
Uncharacterized protein Ensembl ENSDARP00000043919 Ensembl ENSDARP00000104466

Gene names

Name:	mthfd2 ZFIN ZDB-GENE-040704-20 Ensembl ENSDARP00000043919 Ensembl ENSDARP00000104466
Synonyms:	LOC100331625 Ensembl ENSDARP00000043919

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Hydrolase EMBL AAH74043.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	mitochondrion Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	methenyltetrahydrofolate cyclohydrolase activity Inferred from Biological aspect of Ancestor. Source: RefGenome methylenetetrahydrofolate dehydrogenase (NAD+) activity Inferred from Biological aspect of Ancestor. Source: RefGenome methylenetetrahydrofolate dehydrogenase (NADP+) activity Inferred from Biological aspect of Ancestor. Source: RefGenome nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6GMK2 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: EEC4615A720668EB	FASTA	338	36,936
	10 20 30 40 50 60 MATLRALRKL CRHFHHQTCS FHLSSSRQDA VVISGRKLAR QIRNEARDDV EEWVSAGNRR 70 80 90 100 110 120 PHLSVVLVGD NPASHSYVLN KTRAAAEVGI SSETILKPSN ISEEELLDLI VKLNSDHRVD 130 140 150 160 170 180 GLLVQLPLPD HIDERRVCNA VCPGKDVDGF HVVNVGRMCL DQSTMLPATP WGVWEIIKRT 190 200 210 220 230 240 GIETLGKNVL VAGRSKNVGM PIAMLLHTDG RHERPGGDAT VTISHRYTPK EQLRQHTKIA 250 260 270 280 290 300 DIIVAAAGIP NLITADMIKE GAAVIDVGIN RILDPMTGKN RLVGDVDFEG VRKKASFITP 310 320 330 VPGGVGPMTV AMLMKNTIIA AKNMILTPPQ RVRMAASS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Whole EMBL AAH74043.1.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Singapore local strain EMBL AAI55263.1. Tissue: Embryo EMBL AAI55263.1.
[3]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000043919 Ensembl ENSDARP00000104466.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000043919.
[5]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000043919 Ensembl ENSDARP00000104466.
[6]	Ensembl Submitted (NOV-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000104466.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR847941 Genomic DNA. No translation available. CT978957 Genomic DNA. No translation available. BC074043 mRNA. Translation: AAH74043.1. BC155262 mRNA. Translation: AAI55263.1.
IPI	IPI00482184.
RefSeq	NP_001002181.1. NM_001002181.1. XP_002662245.1. XM_002662199.1.
UniGene	Dr.76909.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000043920; ENSDARP00000043919; ENSDARG00000026666. ENSDART00000125952; ENSDARP00000104466; ENSDARG00000090044.
GeneID	100004977. 100331625.
KEGG	dre:100004977. dre:100331625.
Organism-specific databases
CTD	10797.
ZFIN	ZDB-GENE-040704-20. mthfd2.
Phylogenomic databases
GeneTree	ENSGT00630000089817.
HOVERGEN	HBG006411.
InParanoid	Q6GMK2.
KO	K13403.
OMA	HSNVVGK.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01576. THF_DHG_CYH.
InterPro	IPR016040. NAD(P)-bd_dom. IPR000672. THF_DH/CycHdrlase. IPR020630. THF_DH/CycHdrlase_cat_dom. IPR020867. THF_DH/CycHdrlase_CS. IPR020631. THF_DH/CycHdrlase_NAD-bd_dom. [Graphical view]
Pfam	PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view]
PRINTS	PR00085. THFDHDRGNASE.
PROSITE	PS00766. THF_DHG_CYH_1. 1 hit. PS00767. THF_DHG_CYH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20786462.

Entry information

Entry name

Q6GMK2_DANRE

Accession

Primary (citable) accession number: Q6GMK2

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)