ID   Q6GMJ4_DANRE            Unreviewed;       366 AA.
AC   Q6GMJ4;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Histone deacetylase 11 {ECO:0000313|RefSeq:NP_001002171.1};
DE            EC=3.5.1.98 {ECO:0000313|RefSeq:NP_001002171.1};
DE   SubName: Full=Zgc:91942 {ECO:0000313|EMBL:AAH74052.1, ECO:0000313|EMBL:AAI65866.1};
GN   Name=hdac11 {ECO:0000313|ZFIN:ZDB-GENE-040704-7};
GN   Synonyms=zgc:91942 {ECO:0000313|RefSeq:NP_001002171.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH74052.1};
RN   [1] {ECO:0000313|EMBL:AAH74052.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65866.1}, and Whole
RC   {ECO:0000313|EMBL:AAH74052.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|RefSeq:NP_001002171.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24240475;
RA   Huang H.T., Kathrein K.L., Barton A., Gitlin Z., Huang Y.H., Ward T.P.,
RA   Hofmann O., Dibiase A., Song A., Tyekucheva S., Hide W., Zhou Y., Zon L.I.;
RT   "A network of epigenetic regulators guides developmental haematopoiesis in
RT   vivo.";
RL   Nat. Cell Biol. 15:1516-1525(2013).
RN   [3] {ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|RefSeq:NP_001002171.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27189481;
RA   Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA   Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA   Bobe J.;
RT   "Gene evolution and gene expression after whole genome duplication in fish:
RT   the PhyloFish database.";
RL   BMC Genomics 17:368-368(2016).
RN   [5] {ECO:0000313|RefSeq:NP_001002171.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [6] {ECO:0000313|RefSeq:NP_001002171.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28516954; DOI=10.1038/ncomms15368;
RA   Hai Y., Shinsky S.A., Porter N.J., Christianson D.W.;
RT   "Histone deacetylase 10 structure and molecular function as a polyamine
RT   deacetylase.";
RL   Nat. Commun. 8:15368-15368(2017).
RN   [7] {ECO:0000313|RefSeq:NP_001002171.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30267687; DOI=10.1016/j.isci.2018.08.008;
RA   Mitra S., Sharma P., Kaur S., Khursheed M.A., Gupta S., Ahuja R.,
RA   Kurup A.J., Chaudhary M., Ramachandran R.;
RT   "Histone Deacetylase-Mediated Muller Glia Reprogramming through Her4.1-
RT   Lin28a Axis Is Essential for Retina Regeneration in Zebrafish.";
RL   IScience 7:68-84(2018).
RN   [8] {ECO:0000313|RefSeq:NP_001002171.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30615915;
RA   Fellous A., Earley R.L., Silvestre F.;
RT   "Identification and expression of mangrove rivulus (Kryptolebias
RT   marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT)
RT   genes.";
RL   Gene 691:56-69(2019).
RN   [9] {ECO:0000313|RefSeq:NP_001002171.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC074052; AAH74052.1; -; mRNA.
DR   EMBL; BC165866; AAI65866.1; -; mRNA.
DR   RefSeq; NP_001002171.1; NM_001002171.1.
DR   GeneID; 431718; -.
DR   KEGG; dre:431718; -.
DR   AGR; ZFIN:ZDB-GENE-040704-7; -.
DR   CTD; 79885; -.
DR   ZFIN; ZDB-GENE-040704-7; hdac11.
DR   OrthoDB; 239005at2759; -.
DR   Proteomes; UP000000437; Chromosome 11.
DR   GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR   GO; GO:0004407; F:histone deacetylase activity; IBA:GO_Central.
DR   CDD; cd09993; HDAC_classIV; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR044150; HDAC_classIV.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF33; HISTONE DEACETYLASE 11; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN          46..326
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
SQ   SEQUENCE   366 AA;  40440 MW;  C8BD43C86AF899C7 CRC64;
     MSKKEDSGGK KCSHHTELYA EVPASCLPIV YSPEYNITFM GLEKLHPFDA GKWGKVIRFL
     KEEQFITDEI IVLAREASEA DLLVVHTARY LNRLKWSLVV ATITEIPPLL FLPNFLVQRK
     VLRPLRTQTG GTIMAGKLAI DRGWAINVGG GFHHCSSDKG GGFCAYADIT LAIKFLFERV
     EGVASATIID LDAHQGNGHE RDFLEDRRVY IMDVYNRHIY PGDGYAKRAI KRKVELDWGT
     EDSEYLQKVD LHSEGALNEA RPDIIIYNAG TDILDGDPLG GLAISPQGII KRDEIIFRAA
     RRRGIPILMV TSGGYQKKTA RIIADSILNL HRQGLIGEEA LDVAGPSHVS LMMSKSVSSG
     ATLAAI
//