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Q6GMH3

- TWF2_DANRE

UniProt

Q6GMH3 - TWF2_DANRE

Protein

Twinfilin-2

Gene

twf2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.By similarity

    GO - Biological processi

    1. negative regulation of actin filament polymerization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Twinfilin-2
    Alternative name(s):
    Twinfilin-1-like protein
    Gene namesi
    Name:twf2
    Synonyms:ptk9l, twf1l
    ORF Names:zgc:91817
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 6

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasmperinuclear region By similarity
    Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Twinfilin-2PRO_0000233140Add
    BLAST

    Proteomic databases

    PRIDEiQ6GMH3.

    Expressioni

    Gene expression databases

    BgeeiQ6GMH3.

    Interactioni

    Subunit structurei

    Interacts with G-actin; ADP-actin form and capping protein (CP).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GMH3.
    SMRiQ6GMH3. Positions 8-135, 159-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 137135ADF-H 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini175 – 311137ADF-H 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ADF-H domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00530000063965.
    HOGENOMiHOG000168296.
    HOVERGENiHBG000848.
    KOiK08870.
    OMAiHATPELK.
    OrthoDBiEOG79GT6W.
    PhylomeDBiQ6GMH3.
    TreeFamiTF352598.

    Family and domain databases

    Gene3Di3.40.20.10. 2 hits.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028458. Twinfilin.
    [Graphical view]
    PANTHERiPTHR13759. PTHR13759. 1 hit.
    PfamiPF00241. Cofilin_ADF. 2 hits.
    [Graphical view]
    SMARTiSM00102. ADF. 2 hits.
    [Graphical view]
    PROSITEiPS51263. ADF_H. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GMH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLVLVVTEE LREFLARARN GTGRLIQVLI RDEQLVLGAY REPRHSWDKD    50
    YDPVLLPLLD PLEPCYILYR LDSKNAQGYE WLFISWSPDQ SPVRQKMLYA 100
    ATRATVKKEF GGGHVKDEMF GTVEEDICLQ GYLRHITSCS APAPLTVAEQ 150
    ELQRIKITEV KAEISVDPKH QTLQGLAFPL QAEAKRALKQ LAERRINYIQ 200
    LKLDTEKETI DLVHTSPTDI RDLPCRIPLD TPRYHFFLYK HSHEGDYLES 250
    VVFIYSMPGY SCSIKERMLY SSCKSRLLDE VERDFHLEVA KKLEIDSGEE 300
    LTEEYLYDEV HPKQHAHKQA FAKPRGPAGK RGNKRLIKGG GENGGNS 347
    Length:347
    Mass (Da):39,859
    Last modified:July 19, 2004 - v1
    Checksum:i948D3BCD3A0D7B21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074077 mRNA. Translation: AAH74077.1.
    RefSeqiNP_001009897.1. NM_001009897.1.
    UniGeneiDr.155497.

    Genome annotation databases

    EnsembliENSDART00000065006; ENSDARP00000065005; ENSDARG00000094792.
    GeneIDi100310784.
    KEGGidre:100310784.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Molecular embrace - Issue 73 of August 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074077 mRNA. Translation: AAH74077.1 .
    RefSeqi NP_001009897.1. NM_001009897.1.
    UniGenei Dr.155497.

    3D structure databases

    ProteinModelPortali Q6GMH3.
    SMRi Q6GMH3. Positions 8-135, 159-311.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6GMH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000065006 ; ENSDARP00000065005 ; ENSDARG00000094792 .
    GeneIDi 100310784.
    KEGGi dre:100310784.

    Organism-specific databases

    CTDi 11344.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00530000063965.
    HOGENOMi HOG000168296.
    HOVERGENi HBG000848.
    KOi K08870.
    OMAi HATPELK.
    OrthoDBi EOG79GT6W.
    PhylomeDBi Q6GMH3.
    TreeFami TF352598.

    Miscellaneous databases

    PROi Q6GMH3.

    Gene expression databases

    Bgeei Q6GMH3.

    Family and domain databases

    Gene3Di 3.40.20.10. 2 hits.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR028458. Twinfilin.
    [Graphical view ]
    PANTHERi PTHR13759. PTHR13759. 1 hit.
    Pfami PF00241. Cofilin_ADF. 2 hits.
    [Graphical view ]
    SMARTi SM00102. ADF. 2 hits.
    [Graphical view ]
    PROSITEi PS51263. ADF_H. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTWF2_DANRE
    AccessioniPrimary (citable) accession number: Q6GMH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3