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Q6GMH3 (TWF2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Twinfilin-2
Alternative name(s):
Twinfilin-1-like protein
Gene names
Name:twf2
Synonyms:ptk9l, twf1l
ORF Names:zgc:91817
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin By similarity.

Subunit structure

Interacts with G-actin; ADP-actin form and capping protein (CP) By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cytoplasmperinuclear region By similarity. Note: Perinuclear and G-actin-rich cortical actin structure sublocalization By similarity.

Sequence similarities

Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.

Contains 2 ADF-H domains.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of actin filament polymerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Twinfilin-2
PRO_0000233140

Regions

Domain3 – 137135ADF-H 1
Domain175 – 311137ADF-H 2

Sequences

Sequence LengthMass (Da)Tools
Q6GMH3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 948D3BCD3A0D7B21

FASTA34739,859
        10         20         30         40         50         60 
MFLVLVVTEE LREFLARARN GTGRLIQVLI RDEQLVLGAY REPRHSWDKD YDPVLLPLLD 

        70         80         90        100        110        120 
PLEPCYILYR LDSKNAQGYE WLFISWSPDQ SPVRQKMLYA ATRATVKKEF GGGHVKDEMF 

       130        140        150        160        170        180 
GTVEEDICLQ GYLRHITSCS APAPLTVAEQ ELQRIKITEV KAEISVDPKH QTLQGLAFPL 

       190        200        210        220        230        240 
QAEAKRALKQ LAERRINYIQ LKLDTEKETI DLVHTSPTDI RDLPCRIPLD TPRYHFFLYK 

       250        260        270        280        290        300 
HSHEGDYLES VVFIYSMPGY SCSIKERMLY SSCKSRLLDE VERDFHLEVA KKLEIDSGEE 

       310        320        330        340 
LTEEYLYDEV HPKQHAHKQA FAKPRGPAGK RGNKRLIKGG GENGGNS 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC074077 mRNA. Translation: AAH74077.1.
RefSeqNP_001009897.1. NM_001009897.1.
UniGeneDr.155497.

3D structure databases

ProteinModelPortalQ6GMH3.
SMRQ6GMH3. Positions 8-135, 159-311.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6GMH3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000065006; ENSDARP00000065005; ENSDARG00000094792.
GeneID100310784.
KEGGdre:100310784.

Organism-specific databases

CTD11344.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00530000063965.
HOGENOMHOG000168296.
HOVERGENHBG000848.
KOK08870.
OMAHATPELK.
OrthoDBEOG79GT6W.
PhylomeDBQ6GMH3.
TreeFamTF352598.

Gene expression databases

BgeeQ6GMH3.

Family and domain databases

InterProIPR002108. ADF-H.
IPR028458. Twinfilin.
[Graphical view]
PANTHERPTHR13759. PTHR13759. 1 hit.
PfamPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTSM00102. ADF. 2 hits.
[Graphical view]
PROSITEPS51263. ADF_H. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ6GMH3.

Entry information

Entry nameTWF2_DANRE
AccessionPrimary (citable) accession number: Q6GMH3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries