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Protein

Twinfilin-2

Gene

twf2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).By similarity

GO - Biological processi

  1. negative regulation of actin filament polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Twinfilin-2
Alternative name(s):
Twinfilin-1-like protein
Gene namesi
Name:twf2
Synonyms:ptk9l, twf1l
ORF Names:zgc:91817
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 6

Subcellular locationi

  1. Cytoplasmcytoskeleton By similarity
  2. Cytoplasmperinuclear region By similarity

  3. Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Twinfilin-2PRO_0000233140Add
BLAST

Proteomic databases

PRIDEiQ6GMH3.

Expressioni

Gene expression databases

BgeeiQ6GMH3.

Interactioni

Subunit structurei

Interacts with G-actin; ADP-actin form and capping protein (CP).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GMH3.
SMRiQ6GMH3. Positions 8-135, 159-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 137135ADF-H 1PROSITE-ProRule annotationAdd
BLAST
Domaini175 – 311137ADF-H 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ADF-H domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00530000063965.
HOGENOMiHOG000168296.
HOVERGENiHBG000848.
InParanoidiQ6GMH3.
KOiK08870.
OMAiHATPELK.
OrthoDBiEOG79GT6W.
PhylomeDBiQ6GMH3.
TreeFamiTF352598.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GMH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLVLVVTEE LREFLARARN GTGRLIQVLI RDEQLVLGAY REPRHSWDKD
60 70 80 90 100
YDPVLLPLLD PLEPCYILYR LDSKNAQGYE WLFISWSPDQ SPVRQKMLYA
110 120 130 140 150
ATRATVKKEF GGGHVKDEMF GTVEEDICLQ GYLRHITSCS APAPLTVAEQ
160 170 180 190 200
ELQRIKITEV KAEISVDPKH QTLQGLAFPL QAEAKRALKQ LAERRINYIQ
210 220 230 240 250
LKLDTEKETI DLVHTSPTDI RDLPCRIPLD TPRYHFFLYK HSHEGDYLES
260 270 280 290 300
VVFIYSMPGY SCSIKERMLY SSCKSRLLDE VERDFHLEVA KKLEIDSGEE
310 320 330 340
LTEEYLYDEV HPKQHAHKQA FAKPRGPAGK RGNKRLIKGG GENGGNS
Length:347
Mass (Da):39,859
Last modified:July 19, 2004 - v1
Checksum:i948D3BCD3A0D7B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074077 mRNA. Translation: AAH74077.1.
RefSeqiNP_001009897.1. NM_001009897.1.
UniGeneiDr.155497.

Genome annotation databases

EnsembliENSDART00000065006; ENSDARP00000065005; ENSDARG00000094792.
GeneIDi100310784.
KEGGidre:100310784.

Cross-referencesi

Web resourcesi

Protein Spotlight

Molecular embrace - Issue 73 of August 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074077 mRNA. Translation: AAH74077.1.
RefSeqiNP_001009897.1. NM_001009897.1.
UniGeneiDr.155497.

3D structure databases

ProteinModelPortaliQ6GMH3.
SMRiQ6GMH3. Positions 8-135, 159-311.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6GMH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000065006; ENSDARP00000065005; ENSDARG00000094792.
GeneIDi100310784.
KEGGidre:100310784.

Organism-specific databases

CTDi11344.

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00530000063965.
HOGENOMiHOG000168296.
HOVERGENiHBG000848.
InParanoidiQ6GMH3.
KOiK08870.
OMAiHATPELK.
OrthoDBiEOG79GT6W.
PhylomeDBiQ6GMH3.
TreeFamiTF352598.

Miscellaneous databases

PROiQ6GMH3.

Gene expression databases

BgeeiQ6GMH3.

Family and domain databases

Gene3Di3.40.20.10. 2 hits.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028458. Twinfilin.
[Graphical view]
PANTHERiPTHR13759. PTHR13759. 1 hit.
PfamiPF00241. Cofilin_ADF. 2 hits.
[Graphical view]
SMARTiSM00102. ADF. 2 hits.
[Graphical view]
PROSITEiPS51263. ADF_H. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTWF2_DANRE
AccessioniPrimary (citable) accession number: Q6GMH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.