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Q6GM82 (ALAT2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine aminotransferase 2

Short name=ALT2
EC=2.6.1.2
Alternative name(s):
Glutamate pyruvate transaminase 2
Short name=GPT 2
Glutamic--alanine transaminase 2
Glutamic--pyruvic transaminase 2
Gene names
Name:gpt2
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate By similarity.

Catalytic activity

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Alanine aminotransferase 2
PRO_0000247535

Amino acid modifications

Modified residue3581N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GM82 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: D90CC482EA1D7B49

FASTA54059,796
        10         20         30         40         50         60 
MSILRGSLRG VLAPNASVVF RSRLPPQLTS ALLCPLRSLS GTPLAEPDGK VTRKMSENGT 

        70         80         90        100        110        120 
CNRILTLDSM NPCIQKVEYA VRGPIVIRAV ELEKELQQGV KKPFTEVIKA NIGDAHAMGQ 

       130        140        150        160        170        180 
KPVTFLRQVS AICLYPELMN DNKFPEDVKQ KAARILQACG GHSIGAYSAS QGIEVIRQDV 

       190        200        210        220        230        240 
AKYIERRDGG ILSDPNNIYL STGASDSIVT MLKLLVSGQG KSRTGVMIPI PQYPLYSAAL 

       250        260        270        280        290        300 
AELDAVQVNY YLDEENCWAL DINELRRALA EARKHCDPKV LCIINPGNPT GQVQSRKCIE 

       310        320        330        340        350        360 
DVIRFAAEEN LFLMADEVYQ DNVYAKGCAF HSFKKVLFEM GPKYSETLEL ASFHSTSKGY 

       370        380        390        400        410        420 
MGECGFRGGY MEVINMDPAV KQQLTKLVSV RLCPPVPGQV LLDVIVNPPK PGEPSYKQFI 

       430        440        450        460        470        480 
SEKQAVLNNL AEKARLTEEI LNQAPGIRCN PVQGAMYSFP RIHIPEKAIK LAQAEGQAPD 

       490        500        510        520        530        540 
MFFCMKLLEE TGICVVPGSG FGQREGTHHF RMTILPPTDK LKSLLERLKD FHQKFMDEYS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC074194 mRNA. Translation: AAH74194.1.
RefSeqNP_001086104.1. NM_001092635.1.
UniGeneXl.21718.

3D structure databases

ProteinModelPortalQ6GM82.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID444533.
KEGGxla:444533.

Organism-specific databases

CTD84706.
XenbaseXB-GENE-5824402. gpt2.

Phylogenomic databases

HOVERGENHBG026148.
KOK00814.

Enzyme and pathway databases

UniPathwayUPA00528; UER00586.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALAT2_XENLA
AccessionPrimary (citable) accession number: Q6GM82
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 19, 2004
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways