Q6GM82 (ALAT2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine aminotransferase 2
Short name=ALT2
EC=2.6.1.2

Alternative name(s):
Glutamate pyruvate transaminase 2
Short name=GPT 2
Glutamic--alanine transaminase 2
Glutamic--pyruvic transaminase 2

Gene names

Name:

gpt2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate By similarity.
Catalytic activity	L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological_process	2-oxoglutarate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB L-alanine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway L-alanine metabolic process Inferred from sequence or structural similarity. Source: UniProtKB biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	L-alanine:2-oxoglutarate aminotransferase activity Inferred from sequence or structural similarity. Source: UniProtKB pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Alanine aminotransferase 2		PRO_0000247535
Amino acid modifications
	Modified residue	358	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GM82 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: D90CC482EA1D7B49	FASTA	540	59,796
	10 20 30 40 50 60 MSILRGSLRG VLAPNASVVF RSRLPPQLTS ALLCPLRSLS GTPLAEPDGK VTRKMSENGT 70 80 90 100 110 120 CNRILTLDSM NPCIQKVEYA VRGPIVIRAV ELEKELQQGV KKPFTEVIKA NIGDAHAMGQ 130 140 150 160 170 180 KPVTFLRQVS AICLYPELMN DNKFPEDVKQ KAARILQACG GHSIGAYSAS QGIEVIRQDV 190 200 210 220 230 240 AKYIERRDGG ILSDPNNIYL STGASDSIVT MLKLLVSGQG KSRTGVMIPI PQYPLYSAAL 250 260 270 280 290 300 AELDAVQVNY YLDEENCWAL DINELRRALA EARKHCDPKV LCIINPGNPT GQVQSRKCIE 310 320 330 340 350 360 DVIRFAAEEN LFLMADEVYQ DNVYAKGCAF HSFKKVLFEM GPKYSETLEL ASFHSTSKGY 370 380 390 400 410 420 MGECGFRGGY MEVINMDPAV KQQLTKLVSV RLCPPVPGQV LLDVIVNPPK PGEPSYKQFI 430 440 450 460 470 480 SEKQAVLNNL AEKARLTEEI LNQAPGIRCN PVQGAMYSFP RIHIPEKAIK LAQAEGQAPD 490 500 510 520 530 540 MFFCMKLLEE TGICVVPGSG FGQREGTHHF RMTILPPTDK LKSLLERLKD FHQKFMDEYS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074194 mRNA. Translation: AAH74194.1.
RefSeq	NP_001086104.1. NM_001092635.1.
UniGene	Xl.21718.
3D structure databases
ProteinModelPortal	Q6GM82.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	444533.
KEGG	xla:444533.
Organism-specific databases
CTD	84706.
Xenbase	XB-GENE-5824402. gpt2.
Phylogenomic databases
HOVERGEN	HBG026148.
KO	K00814.
Enzyme and pathway databases
UniPathway	UPA00528; UER00586.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALAT2_XENLA

Accession

Primary (citable) accession number: Q6GM82

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 19, 2004
Last modified:	March 6, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program