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Q6GM82

- ALAT2_XENLA

UniProt

Q6GM82 - ALAT2_XENLA

Protein

Alanine aminotransferase 2

Gene

gpt2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.By similarity

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: UniProtKB
    2. biosynthetic process Source: InterPro
    3. L-alanine catabolic process Source: UniProtKB-UniPathway
    4. L-alanine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00528; UER00586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine aminotransferase 2 (EC:2.6.1.2)
    Short name:
    ALT2
    Alternative name(s):
    Glutamate pyruvate transaminase 2
    Short name:
    GPT 2
    Glutamic--alanine transaminase 2
    Glutamic--pyruvic transaminase 2
    Gene namesi
    Name:gpt2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5824402. gpt2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Alanine aminotransferase 2PRO_0000247535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei358 – 3581N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GM82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG026148.
    KOiK00814.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GM82-1 [UniParc]FASTAAdd to Basket

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    MSILRGSLRG VLAPNASVVF RSRLPPQLTS ALLCPLRSLS GTPLAEPDGK    50
    VTRKMSENGT CNRILTLDSM NPCIQKVEYA VRGPIVIRAV ELEKELQQGV 100
    KKPFTEVIKA NIGDAHAMGQ KPVTFLRQVS AICLYPELMN DNKFPEDVKQ 150
    KAARILQACG GHSIGAYSAS QGIEVIRQDV AKYIERRDGG ILSDPNNIYL 200
    STGASDSIVT MLKLLVSGQG KSRTGVMIPI PQYPLYSAAL AELDAVQVNY 250
    YLDEENCWAL DINELRRALA EARKHCDPKV LCIINPGNPT GQVQSRKCIE 300
    DVIRFAAEEN LFLMADEVYQ DNVYAKGCAF HSFKKVLFEM GPKYSETLEL 350
    ASFHSTSKGY MGECGFRGGY MEVINMDPAV KQQLTKLVSV RLCPPVPGQV 400
    LLDVIVNPPK PGEPSYKQFI SEKQAVLNNL AEKARLTEEI LNQAPGIRCN 450
    PVQGAMYSFP RIHIPEKAIK LAQAEGQAPD MFFCMKLLEE TGICVVPGSG 500
    FGQREGTHHF RMTILPPTDK LKSLLERLKD FHQKFMDEYS 540
    Length:540
    Mass (Da):59,796
    Last modified:July 19, 2004 - v1
    Checksum:iD90CC482EA1D7B49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074194 mRNA. Translation: AAH74194.1.
    RefSeqiNP_001086104.1. NM_001092635.1.
    UniGeneiXl.21718.

    Genome annotation databases

    GeneIDi444533.
    KEGGixla:444533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074194 mRNA. Translation: AAH74194.1 .
    RefSeqi NP_001086104.1. NM_001092635.1.
    UniGenei Xl.21718.

    3D structure databases

    ProteinModelPortali Q6GM82.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 444533.
    KEGGi xla:444533.

    Organism-specific databases

    CTDi 84706.
    Xenbasei XB-GENE-5824402. gpt2.

    Phylogenomic databases

    HOVERGENi HBG026148.
    KOi K00814.

    Enzyme and pathway databases

    UniPathwayi UPA00528 ; UER00586 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiALAT2_XENLA
    AccessioniPrimary (citable) accession number: Q6GM82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3