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Protein

Alanine aminotransferase 2

Gene

gpt2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.By similarity

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathwayi

GO - Molecular functioni

  1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: UniProtKB
  2. biosynthetic process Source: InterPro
  3. L-alanine catabolic process Source: UniProtKB-UniPathway
  4. L-alanine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine aminotransferase 2 (EC:2.6.1.2)
Short name:
ALT2
Alternative name(s):
Glutamate pyruvate transaminase 2
Short name:
GPT 2
Glutamic--alanine transaminase 2
Glutamic--pyruvic transaminase 2
Gene namesi
Name:gpt2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5824402. gpt2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Alanine aminotransferase 2PRO_0000247535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei358 – 3581N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GM82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG026148.
KOiK00814.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GM82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILRGSLRG VLAPNASVVF RSRLPPQLTS ALLCPLRSLS GTPLAEPDGK
60 70 80 90 100
VTRKMSENGT CNRILTLDSM NPCIQKVEYA VRGPIVIRAV ELEKELQQGV
110 120 130 140 150
KKPFTEVIKA NIGDAHAMGQ KPVTFLRQVS AICLYPELMN DNKFPEDVKQ
160 170 180 190 200
KAARILQACG GHSIGAYSAS QGIEVIRQDV AKYIERRDGG ILSDPNNIYL
210 220 230 240 250
STGASDSIVT MLKLLVSGQG KSRTGVMIPI PQYPLYSAAL AELDAVQVNY
260 270 280 290 300
YLDEENCWAL DINELRRALA EARKHCDPKV LCIINPGNPT GQVQSRKCIE
310 320 330 340 350
DVIRFAAEEN LFLMADEVYQ DNVYAKGCAF HSFKKVLFEM GPKYSETLEL
360 370 380 390 400
ASFHSTSKGY MGECGFRGGY MEVINMDPAV KQQLTKLVSV RLCPPVPGQV
410 420 430 440 450
LLDVIVNPPK PGEPSYKQFI SEKQAVLNNL AEKARLTEEI LNQAPGIRCN
460 470 480 490 500
PVQGAMYSFP RIHIPEKAIK LAQAEGQAPD MFFCMKLLEE TGICVVPGSG
510 520 530 540
FGQREGTHHF RMTILPPTDK LKSLLERLKD FHQKFMDEYS
Length:540
Mass (Da):59,796
Last modified:July 19, 2004 - v1
Checksum:iD90CC482EA1D7B49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074194 mRNA. Translation: AAH74194.1.
RefSeqiNP_001086104.1. NM_001092635.1.
UniGeneiXl.21718.

Genome annotation databases

GeneIDi444533.
KEGGixla:444533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074194 mRNA. Translation: AAH74194.1.
RefSeqiNP_001086104.1. NM_001092635.1.
UniGeneiXl.21718.

3D structure databases

ProteinModelPortaliQ6GM82.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444533.
KEGGixla:444533.

Organism-specific databases

CTDi84706.
XenbaseiXB-GENE-5824402. gpt2.

Phylogenomic databases

HOVERGENiHBG026148.
KOiK00814.

Enzyme and pathway databases

UniPathwayiUPA00528; UER00586.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiALAT2_XENLA
AccessioniPrimary (citable) accession number: Q6GM82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.