Q6GM78 (ASGL1_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-asparaginase
EC=3.5.1.1

Alternative name(s):
Asparaginase-like protein 1
L-asparagine amidohydrolase

Gene names

Name:

asrgl1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts in asparagine catabolism By similarity.
Catalytic activity	L-asparagine + H2O = L-aspartate + NH3.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Ntn-hydrolase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	asparagine catabolic process via L-aspartate Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	L-asparaginase		PRO_0000305209
Sites
	Active site	166	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GM78 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 6CFFBEC28270C13D	FASTA	309	32,505
	10 20 30 40 50 60 MKPVIVVHGG AGKIVEELDA TYRAGVKRAV LKGYDVLSQG GSALTAVEEA VIVLEDEQIF 70 80 90 100 110 120 NAGHGSVLNE KGDIEMDAII MDGKNLDSGA VSAIRNIANP IKLARLVMEK TDHMLLTCEG 130 140 150 160 170 180 ATLFAKAQGI PEVPNESLVT ERSRKRWMKN LKENSNPVAD QIGLGTVGAV AIDCEGNVAC 190 200 210 220 230 240 ATSTGGLTNK MVGRVGDTAC IGSGGYADNN VGAVSTTGHG ESIMKVILAR LILHHMEQGK 250 260 270 280 290 300 SPEEAADAGL NYMKSRVGGI GGVIIVNSSG DWTAKFSTNQ MSWAAVKDDQ LHIGIYHGEN NVTPLEKAL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074198 mRNA. Translation: AAH74198.1.
RefSeq	NP_001086107.1. NM_001092638.1.
UniGene	Xl.7538.
3D structure databases
HSSP	HSSP built from PDB template 2A8I based on UniProtKB Q9H6P5.
ProteinModelPortal	Q6GM78.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	444536.
KEGG	xla:444536.
Organism-specific databases
CTD	80150.
Xenbase	XB-GENE-989505. asrgl1.
Phylogenomic databases
HOVERGEN	HBG101662.
Family and domain databases
InterPro	IPR000246. Peptidase_T2. [Graphical view]
KO	K13051.
PANTHER	PTHR10188. Peptidase_T2. 1 hit.
Pfam	PF01112. Asparaginase_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASGL1_XENLA

Accession

Primary (citable) accession number: Q6GM78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 19, 2004
Last modified:	November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program