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Protein

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Gene

chuk

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.By similarity

Catalytic activityi

ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].

Enzyme regulationi

Activated when phosphorylated and inactivated when dephosphorylated.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATPPROSITE-ProRule annotation
Active sitei144 – 1441Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 299ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC:2.7.11.10)
Short name:
I kappa-B kinase alpha
Short name:
IKK-A
Short name:
IKK-alpha
Short name:
IkBKA
Alternative name(s):
Conserved helix-loop-helix ubiquitous kinase
Nuclear factor NF-kappa-B inhibitor kinase alpha
Short name:
NFKBIKA
Gene namesi
Name:chuk
Synonyms:ikka
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5910051. chuk.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between the cytoplasm and the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Inhibitor of nuclear factor kappa-B kinase subunit alphaPRO_0000268828Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6GM53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 300286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni453 – 47422Leucine-zipperAdd
BLAST
Regioni736 – 7416NEMO-bindingBy similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG018241.
KOiK04467.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GM53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPPVQHGA VCGPWDMKDR LGTGGFGNVC LYQNRETGEL KAIKSCRLEL
60 70 80 90 100
SVKNKERWCQ EIQIMKRLNH PNVVKACDVP PEMDFLVNDV PHLAMEYCAG
110 120 130 140 150
GDLRKLLNKP ENCCGLKESQ VLNLISDIGS GIQYLHENRI IHRDLKPENI
160 170 180 190 200
VLQECNGKTV HKIIDLGYAK DLDQGSLCTS FVGTLQYLAP ELFENKPYSV
210 220 230 240 250
TVDYWSFGTM AFECIAGFRP FLHNMQPFTW HEKIKKKDHK HIYAYEEMSG
260 270 280 290 300
EIRFSTSLPE PNNLCSIIVD KIETWLQLLL NWDPVQRGGG IDCGRPRCFM
310 320 330 340 350
LMDQIFSLKI VHILNMTSAK IHSFHLQPEE SLHTLQSRIE RETGISTCNQ
360 370 380 390 400
ELLLEMGVSL DPRKPASQCV IDGVKGWDSY MVYLFDKSKT VYEGPFQSRS
410 420 430 440 450
LSECLNYIVQ DSKVQLPIPQ LRKVWAEAVH YVSGLKEDYS RLFQGQRAAM
460 470 480 490 500
LSLLRFNTNL TKMKNTMVSA SQQLDAKLQF FKRSIEIDLE RYSDQMAYGI
510 520 530 540 550
SSEKMLRAWK EMEDKAVCFG KAGEIHFLDE TIMGLHTEIV ELQRSPCARR
560 570 580 590 600
QGDVMEHLEQ RAMELYKQLK PRSPDKAYSD STEMVKILVQ TVQGQDRVLK
610 620 630 640 650
ELFGHLSKLL GCKQKIIDLL PQIEMTVNNI KEADSSLMQM QAKRQREIWH
660 670 680 690 700
LLKIACTQSS TRSLVTASGE TPITSRTSAW SDQSSPQALF SMLTSKDKGR
710 720 730 740
EILRHTIDKN TDYQKLLSNL ILQTQTTMEQ TSLMSMDFSW LNQ
Length:743
Mass (Da):85,152
Last modified:July 19, 2004 - v1
Checksum:i7FB7B4FA325B1860
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074232 mRNA. Translation: AAH74232.1.
RefSeqiNP_001086127.1. NM_001092658.1.
UniGeneiXl.31871.

Genome annotation databases

GeneIDi444556.
KEGGixla:444556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074232 mRNA. Translation: AAH74232.1.
RefSeqiNP_001086127.1. NM_001092658.1.
UniGeneiXl.31871.

3D structure databases

ProteinModelPortaliQ6GM53.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444556.
KEGGixla:444556.

Organism-specific databases

CTDi1147.
XenbaseiXB-GENE-5910051. chuk.

Phylogenomic databases

HOVERGENiHBG018241.
KOiK04467.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiIKKA_XENLA
AccessioniPrimary (citable) accession number: Q6GM53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 19, 2004
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.