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Protein

Phosphatidylinositide phosphatase SAC1

Gene

sacm1l

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC1 (EC:3.1.3.-)
Alternative name(s):
Suppressor of actin mutations 1-like protein
Gene namesi
Name:sacm1l
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-920718. sacm1l.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei520 – 54021HelicalSequence analysisAdd
BLAST
Transmembranei548 – 56821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Phosphatidylinositide phosphatase SAC1PRO_0000317177Add
BLAST

Proteomic databases

PRIDEiQ6GM29.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 450330SACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108454.

Family and domain databases

InterProiIPR002013. SAC_dom.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GM29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAYENLKL HITPEKFYVE ACDPGVEDVL TIDRVSTEVT LSGKKDIPPS
60 70 80 90 100
AITRAIYGIL GTIRLVAGMY LIVITRRKKV GDLLNHSIWK ATDFDIISYK
110 120 130 140 150
KTMLHLTDSQ LQDNKAFLGM LSHVLSVDGF YFSVSYDLTH TLQRLANTSP
160 170 180 190 200
EFQEMSLLER ADQRFVWNGN LLREFSAQPE IQKFAIPVVH GFIAIHSCSI
210 220 230 240 250
NGKYFDWILI SRRSCFRAGV RYYVRGIDSE GHAANFVETE QIVHYNGNKA
260 270 280 290 300
SFVQTRGSIP FYWSQRPNLK YKPKPQISKA VNHMDGFQRH FDSQVISYGK
310 320 330 340 350
QVVLNLVNQK GSEKPLEQEF SQMVSGLGNG MVRYIAFDFH KECSRMRWDR
360 370 380 390 400
LQILVEQVAE TQDEFGYFLV DTEGKVVSQQ DGIFRSNCMD CLDRTNVVQS
410 420 430 440 450
LLARRSLQYQ LQRLGVLHVG QRIEEQIQFE KIYKNAWADN ANACAKQYAG
460 470 480 490 500
TGALKTDFTR TGKRTQWGLL MDGWNSLIRY YKNNFSDGFR QDSIDLFLGN
510 520 530 540 550
YSVEEAYSTS PLHIQTDWKF LALPIIMVVA FSMCIICLLM AGDTWTETLA
560 570 580
YVLFWGTASI GTGAIIMYNG KDFVDAPKLV QKEKMD
Length:586
Mass (Da):66,957
Last modified:July 19, 2004 - v1
Checksum:i32214EF6AB5655EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074260 mRNA. Translation: AAH74260.1.
BC077608 mRNA. Translation: AAH77608.1.
RefSeqiNP_001086149.1. NM_001092680.1.
UniGeneiXl.45771.

Genome annotation databases

GeneIDi444578.
KEGGixla:444578.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074260 mRNA. Translation: AAH74260.1.
BC077608 mRNA. Translation: AAH77608.1.
RefSeqiNP_001086149.1. NM_001092680.1.
UniGeneiXl.45771.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6GM29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444578.
KEGGixla:444578.

Organism-specific databases

CTDi22908.
XenbaseiXB-GENE-920718. sacm1l.

Phylogenomic databases

HOVERGENiHBG108454.

Family and domain databases

InterProiIPR002013. SAC_dom.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAC1_XENLA
AccessioniPrimary (citable) accession number: Q6GM29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: November 11, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.