Q6GM16 (NXN_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoredoxin
EC=1.8.1.8

Gene names

Name:

nxn

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as a redox-dependent negative regulator of the Wnt signaling pathway. May function as a transcriptional regulator. May regulate phosphatase 2A. Ref.2
Catalytic activity	Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.
Subcellular location	Cytoplasm › cytosol By similarity. Nucleus By similarity.
Disruption phenotype	Depletion causes significant defects in head formation with absence of eye structures. Ref.2
Sequence similarities	Belongs to the nucleoredoxin family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Biological process	Differentiation Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
Ligand	NAD
Molecular function	Developmental protein Oxidoreductase
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antioxidant activity Inferred from electronic annotation. Source: InterPro protein-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Nucleoredoxin		PRO_0000332936
Regions
	Domain	131 – 305	175	Thioredoxin

Sequences

	Sequence		Length	Mass (Da)
	Q6GM16 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 9990342C03078C1F	FASTA	414	46,844
	10 20 30 40 50 60 MSGPGLLVEL LGEKLVNSER EEADVQALGS RVSLIGLLFG CGMSAPCLQL LPGLKDFYCK 70 80 90 100 110 120 TRDRLEIVFV SSDPDQKKWQ LFVKDMPWLA LPYQEKHRKL KLWNKFRISN IPSLIFIEAS 130 140 150 160 170 180 TVKTVCRNGL LLVKDDPEGL EFPWGPKPFC EVIAGPLIRN NSQSQESSTL EGSYVGIYFS 190 200 210 220 230 240 AYWCPPCRSL TRVLVESYRK IKESGQKFEI VLVSADRSEE SFKQYFSEMP WLAVPYSDEA 250 260 270 280 290 300 RRSRLNRLYG IQGIPNLIIL DPKGEVITRQ GRVEVLRDID CKEFPWHPKP VVELTELNAV 310 320 330 340 350 360 QLNEGPCLVL FVDSEDEGES EAAKQLIQPI AEKIIAQHKA KDEDAPLLFF VAGEDDMTDS 370 380 390 400 410 LRDFTNLPEA APLLTILDMS ARAKYVMDVE EITPEIVQSF VTDFLAEKLK PEPI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[2]	"The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled." Funato Y., Michiue T., Asashima M., Miki H. Nat. Cell Biol. 8:501-508(2006) [PubMed: 16604061] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074275 mRNA. Translation: AAH74275.1.
RefSeq	NP_001086161.1. NM_001092692.1.
UniGene	Xl.12749.
3D structure databases
HSSP	HSSP built from PDB template 1O73 based on UniProtKB O77404.
ProteinModelPortal	Q6GM16.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	444590.
KEGG	xla:444590.
Organism-specific databases
CTD	64359.
Xenbase	XB-GENE-1001776. nxn.
Phylogenomic databases
HOVERGEN	HBG053461.
Family and domain databases
InterPro	IPR000866. AhpC/TSA. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 3 hits.
PROSITE	PS00194. THIOREDOXIN_1. False negative. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NXN_XENLA

Accession

Primary (citable) accession number: Q6GM16

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 19, 2004
Last modified:	October 19, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program