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Q6GM06

- OTU6B_XENLA

UniProt

Q6GM06 - OTU6B_XENLA

Protein

OTU domain-containing protein 6B

Gene

otud6b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei158 – 1581By similarity
    Active sitei161 – 1611NucleophileBy similarity
    Active sitei280 – 2801By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6B (EC:3.4.19.12)
    Gene namesi
    Name:otud6b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294OTU domain-containing protein 6BPRO_0000076283Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GM06.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini150 – 287138OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni155 – 1617Cys-loopBy similarity
    Regioni222 – 23211Variable-loopBy similarityAdd
    BLAST
    Regioni270 – 28011His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG080227.
    KOiK18342.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GM06-1 [UniParc]FASTAAdd to Basket

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    MDVAEENSEE ALLIKQQRKE KKEVQAKIQC MKNSVPKNDK KRRKQMTEDI    50
    AKLEAEVEAR HKEELEALAQ KPTEPTQVSS ITNGVTSLDL GSEEPVQQPR 100
    VSKAQKRREK KAAQEKERDD RIAEAEIANL SGARHLESQK LAQILAEREL 150
    QIRQIPSDGH CMYRAIEHQL NEQGNSLTVA NLRSQTADYM QKRAEDFLPF 200
    LTNSSTGDMY TQEEFQKYCT DIVNTPAWGG QLELRALSHI LKTPIEVIQA 250
    ESLPIVIGEE YSNKPITLVY MRHAYGLGEH YNSVEQLDTS TENS 294
    Length:294
    Mass (Da):33,432
    Last modified:July 19, 2004 - v1
    Checksum:i48293B8CD6D4E7F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074286 mRNA. Translation: AAH74286.1.
    RefSeqiNP_001086171.1. NM_001092702.1.
    UniGeneiXl.15114.

    Genome annotation databases

    GeneIDi444600.
    KEGGixla:444600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074286 mRNA. Translation: AAH74286.1 .
    RefSeqi NP_001086171.1. NM_001092702.1.
    UniGenei Xl.15114.

    3D structure databases

    ProteinModelPortali Q6GM06.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 444600.
    KEGGi xla:444600.

    Organism-specific databases

    CTDi 51633.

    Phylogenomic databases

    HOVERGENi HBG080227.
    KOi K18342.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiOTU6B_XENLA
    AccessioniPrimary (citable) accession number: Q6GM06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3