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Q6GM06

- OTU6B_XENLA

UniProt

Q6GM06 - OTU6B_XENLA

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Protein

OTU domain-containing protein 6B

Gene

otud6b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581By similarity
Active sitei161 – 1611NucleophileBy similarity
Active sitei280 – 2801By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Gene namesi
Name:otud6b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294OTU domain-containing protein 6BPRO_0000076283Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6GM06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 287138OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni155 – 1617Cys-loopBy similarity
Regioni222 – 23211Variable-loopBy similarityAdd
BLAST
Regioni270 – 28011His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG080227.
KOiK18342.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GM06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVAEENSEE ALLIKQQRKE KKEVQAKIQC MKNSVPKNDK KRRKQMTEDI
60 70 80 90 100
AKLEAEVEAR HKEELEALAQ KPTEPTQVSS ITNGVTSLDL GSEEPVQQPR
110 120 130 140 150
VSKAQKRREK KAAQEKERDD RIAEAEIANL SGARHLESQK LAQILAEREL
160 170 180 190 200
QIRQIPSDGH CMYRAIEHQL NEQGNSLTVA NLRSQTADYM QKRAEDFLPF
210 220 230 240 250
LTNSSTGDMY TQEEFQKYCT DIVNTPAWGG QLELRALSHI LKTPIEVIQA
260 270 280 290
ESLPIVIGEE YSNKPITLVY MRHAYGLGEH YNSVEQLDTS TENS
Length:294
Mass (Da):33,432
Last modified:July 19, 2004 - v1
Checksum:i48293B8CD6D4E7F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074286 mRNA. Translation: AAH74286.1.
RefSeqiNP_001086171.1. NM_001092702.1.
UniGeneiXl.15114.

Genome annotation databases

GeneIDi444600.
KEGGixla:444600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074286 mRNA. Translation: AAH74286.1 .
RefSeqi NP_001086171.1. NM_001092702.1.
UniGenei Xl.15114.

3D structure databases

ProteinModelPortali Q6GM06.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 444600.
KEGGi xla:444600.

Organism-specific databases

CTDi 51633.

Phylogenomic databases

HOVERGENi HBG080227.
KOi K18342.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiOTU6B_XENLA
AccessioniPrimary (citable) accession number: Q6GM06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3